GINS3 - GINS complex subunit 3 Gene

Homo sapiens

Also known as PSF3

Gene ID: 64785 | Gene type: protein coding

About GINS3

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:58,392,471-58,406,147 (from NCBI)

This gene has 10 transcripts (splice variants) and 191 orthologues. Ubiquitous expression in lymph node (RPKM 4.0), testis (RPKM 3.9) and 25 other tissues.

Summary

This gene encodes a protein subunit of the GINS heterotetrameric complex, which is essential for the initiation of DNA replication and replisome progression in eukaryotes. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GINS3 Products(3)

mRNA	Protein	Name
NM_001126129.2	NP_001119601.1	DNA replication complex GINS protein PSF3 isoform a
NM_001126130.2	NP_001119602.1	DNA replication complex GINS protein PSF3 isoform c
NM_022770.4	NP_073607.2	DNA replication complex GINS protein PSF3 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19805216	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA unwinding involved in DNA replication	IDA IDA: Inferred from direct assay	22474384	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of CMG complex	IPI IPI: Inferred from physical interaction	22474384	GOA
part of GINS complex	IPI IPI: Inferred from physical interaction	17417653	GOA
located in nucleus	IDA IDA: Inferred from direct assay	22474384	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GINS3 Protein Structure

Sld5

0
100
200
216 a.a.

Protein Preferred Names

Protein Names

DNA replication complex GINS protein PSF3

GINS complex subunit 3 (Psf3 homolog)

GINS3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GINS3	Q9BRX5	CTNNA3	Homo sapiens	Q9UI47-2	Validated Y2H	32296183
Intra	GINS3	Q9BRX5	VAC14	Homo sapiens	Q08AM6	Y2H Prey Pooling	26871637
Intra	GINS3	Q9BRX5	VAC14	Homo sapiens	Q08AM6	Y2H Prey Pooling	32296183
Intra	GINS3	Q9BRX5	VAC14	Homo sapiens	Q08AM6	Validated Y2H	26871637
Intra	GINS3	Q9BRX5	VAC14	Homo sapiens	Q08AM6	Y2H Array	26871637
Intra	GINS3	Q9BRX5	VAC14	Homo sapiens	Q08AM6	Y2H Array	32296183
Intra	GINS3	Q9BRX5	ICAM5	Homo sapiens	Q9UMF0	Validated Y2H	32814053
Intra	GINS3	Q9BRX5	ICAM5	Homo sapiens	Q9UMF0	Y2H Array	32814053
Intra	GINS3	Q9BRX5	ICAM5	Homo sapiens	Q9UMF0	Y2H Pooling	32814053
Intra	GINS3	Q9BRX5	UQCRB	Homo sapiens	P14927	Validated Y2H	32814053
Intra	GINS3	Q9BRX5	UQCRB	Homo sapiens	P14927	Y2H Pooling	32814053
Intra	GINS3	Q9BRX5	UQCRB	Homo sapiens	P14927	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Adrenal Cortical Adenocarcinoma

Adrenal Cortex Adenocarcinoma

Adrenocortical Carcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05432	GINS3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GINS3	VGNC	VGNC:62555
Rattus norvegicus	GINS3	RGD	RGD:1308153
Mus musculus	GINS3	MGD	MGI:1926083
Bos taurus	GINS3	VGNC	VGNC:29362
Canis familiaris	GINS3	VGNC	VGNC:41222
Macaca mulatta	GINS3	VGNC	VGNC:73014

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