CEP85 - centrosomal protein 85 Gene

Homo sapiens

Also known as CCDC21

Gene ID: 64793 | Gene type: protein coding

About CEP85

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:26,234,200-26,278,808 (from NCBI)

This gene has 8 transcripts (splice variants), 208 orthologues and 1 paralogue. Broad expression in testis (RPKM 23.4), heart (RPKM 8.7) and 20 other tissues.

Summary

This gene encodes a protein that belongs to the centrosome-associated family of proteins. The centrosome is a subcellular organelle in the animal cell that functions as a microtubule organizing center and is involved in cell-cycle progression. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

CEP85 Products(4)

mRNA	Protein	Name
NM_001281517.3	NP_001268446.1	centrosomal protein of 85 kDa isoform 2
NM_001281518.3	NP_001268447.1	centrosomal protein of 85 kDa isoform 3
NM_001319944.2	NP_001306873.1	centrosomal protein of 85 kDa isoform 4
NM_022778.5	NP_073615.2	centrosomal protein of 85 kDa isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IDA IDA: Inferred from direct assay	29712910	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18985028	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell migration	IMP IMP: Inferred from mutant phenotype	32107292	GOA
involved in centriole assembly	IMP IMP: Inferred from mutant phenotype	29712910	GOA
involved in centriole replication	IMP IMP: Inferred from mutant phenotype	29712910	GOA
involved in negative regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	26220856	GOA
involved in regulation of mitotic centrosome separation	IMP IMP: Inferred from mutant phenotype	26220856	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell cortex	IDA IDA: Inferred from direct assay	32107292	GOA
located in centriole	IDA IDA: Inferred from direct assay	29712910	GOA
located in centrosome	IDA IDA: Inferred from direct assay	21399614	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	21399614	GOA
located in pericentriolar material	IDA IDA: Inferred from direct assay	26220856	GOA
located in spindle pole	IDA IDA: Inferred from direct assay	21399614	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

centrosomal protein of 85 kDa

centrosomal protein 85kDa

CEP85 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CEP85	Q6P2H3	TERF1	Homo sapiens	P54274	Pull Down	21044950
Cross	CEP85	Q6P2H3	Q9WMX2-PRO_0000037548	Hepatitis C virus	Q9WMX2-PRO_0000037548	Pull Down	18985028

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Visual Agnosia

Primary Visual Agnosia

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly	Mcph
True Microcephaly	Microcephalia Vera
Microcephaly Vera	Microcephaly Primary Hereditary
Microcephaly, Primary, Autosomal Recessive	Primary Microcephaly

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02526	CEP85 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS02527	CEP85L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CEP85	VGNC	VGNC:39140
Bos taurus	CEP85	VGNC	VGNC:27216
Mus musculus	CEP85	MGD	MGI:1917262
Macaca mulatta	CEP85	VGNC	VGNC:71096
Rattus norvegicus	CEP85	RGD	RGD:1311520
Felis catus	CEP85	VGNC	VGNC:60786

Name
Email *

	Sorry, but the email address you supplied was invalid.