DEPTOR - DEP domain containing MTOR interacting protein Gene

Homo sapiens

Also known as DEP.6; DEPDC6

Gene ID: 64798 | Gene type: protein coding

About DEPTOR

Cytogenetic location: 8q24.12 Genomic coordinates (GRCh38): 8:119,873,722-120,050,918 (from NCBI)

This gene has 3 transcripts (splice variants), 210 orthologues and 3 paralogues. Broad expression in thyroid (RPKM 29.3), adrenal (RPKM 13.7) and 17 other tissues.

Summary

Involved in several processes, including negative regulation of TOR signaling; negative regulation of cell size; and negative regulation of protein kinase activity. [provided by Alliance of Genome Resources, Apr 2022]

DEPTOR Products(2)

mRNA	Protein	Name
NM_001283012.2	NP_001269941.1	DEP domain-containing mTOR-interacting protein isoform 2
NM_022783.4	NP_073620.2	DEP domain-containing mTOR-interacting protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphatidic acid binding	IDA IDA: Inferred from direct assay	25936805	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19446321	GOA
enables protein kinase inhibitor activity	IDA IDA: Inferred from direct assay	22017875	GOA
enables protein serine/threonine kinase inhibitor activity	IDA IDA: Inferred from direct assay	22017875	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of TOR signaling	IMP IMP: Inferred from mutant phenotype	19446321	GOA
involved in negative regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	22017875	GOA
involved in negative regulation of TORC1 signaling	IGI IGI: Inferred from genetic interaction	33110214	GOA
involved in negative regulation of TORC2 signaling	IDA IDA: Inferred from direct assay	25936805	GOA
involved in negative regulation of TORC2 signaling	IGI IGI: Inferred from genetic interaction	33110214	GOA
involved in negative regulation of cell size	IMP IMP: Inferred from mutant phenotype	19446321	GOA
involved in negative regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	19446321	GOA
involved in positive regulation of autophagy	IDA IDA: Inferred from direct assay	22017875	GOA
involved in regulation of extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	19446321	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in lysosomal membrane	IDA IDA: Inferred from direct assay	25936805	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DEPTOR Protein Structure

DEP

0
100
200
300
409 a.a.

Protein Preferred Names

Protein Names

DEP domain-containing mTOR-interacting protein

DEP domain containing 6

DEPTOR Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DEPTOR	Q8TB45	ANKRD11	Homo sapiens	X5D778	Validated Y2H	32296183
Intra	DEPTOR	Q8TB45	ANKRD11	Homo sapiens	X5D778	Y2H Array	32296183
Intra	DEPTOR	Q8TB45	ANKRD11	Homo sapiens	X5D778	Y2H Prey Pooling	32296183
Intra	DEPTOR	Q8TB45	CCDC110	Homo sapiens	Q8TBZ0	Y2H Prey Pooling	25416956
Intra	DEPTOR	Q8TB45	CCDC110	Homo sapiens	Q8TBZ0	Validated Y2H	25416956
Intra	DEPTOR	Q8TB45	CCDC110	Homo sapiens	Q8TBZ0	Y2H Array	25416956
Intra	DEPTOR	Q8TB45	TRAF1	Homo sapiens	Q13077	Y2H Array	25416956
Intra	DEPTOR	Q8TB45	MTOR	Homo sapiens	P42345	Anti Bait CoIP	19446321
Intra	DEPTOR	Q8TB45	MTOR	Homo sapiens	P42345	Anti Tag CoIP	19446321
Cross	DEPTOR	Q8TB45	Mtor	Rattus norvegicus	P42346	Anti Tag CoIP	19446321

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Subependymal Glioma

Mixed Subependymoma-Ependymoma	Subependymal Astrocytoma
Who Grade I Ependymal Tumor	Glioma, Subependymal

Neurodegeneration With Brain Iron Accumulation

Nbia	Neurodegeneration With Brain Iron Accumulation Disorders
Neurodegeneration, With Brain Iron Accumulation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-132902	DEPTOR-IN-1	Inhibitor	99.09%	Unkown
HY-RS03697	DEPTOR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-164385	NSC126405	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DEPTOR	VGNC	VGNC:28008
Mus musculus	DEPTOR	MGD	MGI:2146322
Macaca mulatta	DEPTOR	VGNC	VGNC:71691
Canis familiaris	DEPTOR	VGNC	VGNC:39900
Felis catus	DEPTOR	VGNC	VGNC:61446
Rattus norvegicus	DEPTOR	RGD	RGD:1561030

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