IL25 - interleukin 25 Gene

Homo sapiens

Also known as IL17E

Gene ID: 64806 | Gene type: protein coding

About IL25

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:23,372,809-23,376,403 (from NCBI)

This gene has 2 transcripts (splice variants), 89 orthologues and 5 paralogues. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be a pro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

IL25 Products(2)

mRNA	Protein	Name
NM_022789.4	NP_073626.1	interleukin-25 isoform 1 precursor
NM_172314.2	NP_758525.1	interleukin-25 isoform 2 precursor

IL25 Protein Structure

IL17

0
100
177 a.a.

Protein Preferred Names

Protein Names

interleukin-25

interleukin-17E

Recombinant IL25 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72555	IL-25/IL-17E Protein, Human (HEK293, His)	Q9H293-1 (Y33-G177)	≥95%
HY-P74813	IL-25/IL-17E Protein, Human (HEK293, Fc)	Q9H293-1 (Y33-G177)	≥95%
HY-P700116AF	Animal-Free IL-25/IL-17E Protein, Human (His)	Q9H293-1 (Y33-G177)	≥95%
HY-P701012	IL-25/IL-17E Protein, Human (Biotinylated, HEK293, His-Avi)	Q9H293-1 (Y33-G177)	≥95%

Related Diseases

Diseases

Alias

Chronic Mucocutaneous Candidiasis

Candidiasis, Chronic Mucocutaneous	Cmc
Candidiasis Chronic Mucocutaneous

Psoriasis 11

PSORS11	Psoriasis Susceptibility 11
Psoriasis	Psoriasis Vulgaris
Psoriasis 11, Susceptibility To	Pv

Nail Disease

Nail Diseases	Abnormality Of The Nail
Nail Anomaly

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06744	IL25 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	IL25	MGD	MGI:2155888
Canis familiaris	IL25	VGNC	VGNC:41975
Bos taurus	IL25	VGNC	VGNC:30149
Felis catus	IL25	VGNC	VGNC:80950
Macaca mulatta	IL25	VGNC	VGNC:84356
Rattus norvegicus	IL25	RGD	RGD:1561632

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