2. Gene
  3. USP46 - ubiquitin specific peptidase 46 Gene

USP46 - ubiquitin specific peptidase 46 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 64854 | Gene type: protein coding

About USP46

Cytogenetic location: 4q12 Genomic coordinates (GRCh38): 4:52,590,960-52,659,301 (from NCBI)

This gene has 9 transcripts (splice variants), 211 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 11.8), heart (RPKM 7.4) and 23 other tissues.

Summary

Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating Enzymes. USP46 belongs to a large family of cysteine proteases that function as deubiquitinating Enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Jun 2009]

USP46 Products(4)

mRNA Protein Name
NM_001134223.2 NP_001127695.1 ubiquitin carboxyl-terminal hydrolase 46 isoform 2
NM_001286767.2 NP_001273696.1 ubiquitin carboxyl-terminal hydrolase 46 isoform 3
NM_001286768.2 NP_001273697.1 ubiquitin carboxyl-terminal hydrolase 46 isoform 4
NM_022832.4 NP_073743.2 ubiquitin carboxyl-terminal hydrolase 46 isoform 1

USP46 Protein Structure

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (34 - 362)

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  • 366 a.a.
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 46

deubiquitinating enzyme 46

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15557 USP46 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus USP46 VGNC VGNC:66889
Bos taurus USP46 VGNC VGNC:52847
Macaca mulatta USP46 VGNC VGNC:79229
Rattus norvegicus USP46 RGD RGD:1564808
Mus musculus USP46 MGD MGI:1916977
Canis familiaris USP46 VGNC VGNC:51784
Others USP46 NCBI