CDK15 - cyclin dependent kinase 15 Gene

Homo sapiens

Also known as PFTK2; ALS2CR7; PFTAIRE2

Gene ID: 65061 | Gene type: protein coding

About CDK15

Cytogenetic location: 2q33.1 Genomic coordinates (GRCh38): 2:201,806,429-201,895,550 (from NCBI)

This gene has 10 transcripts (splice variants), 198 orthologues and 26 paralogues. Biased expression in ovary (RPKM 1.2), gall bladder (RPKM 0.5) and 13 other tissues.

Summary

Enables protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation and regulation of transcription involved in G1/S transition of mitotic cell cycle. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

CDK15 Products(4)

mRNA	Protein	Name
NM_001261435.1	NP_001248364.1	cyclin-dependent kinase 15 isoform 1
NM_001261436.1	NP_001248365.1	cyclin-dependent kinase 15 isoform 2
NM_001366386.2	NP_001353315.1	cyclin-dependent kinase 15 isoform 4
NM_139158.2	NP_631897.1	cyclin-dependent kinase 15 isoform 3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22939624	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	24866247	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDK15 Protein Structure

Pkinase

0
100
200
300
400
429 a.a.

Protein Preferred Names

Protein Names

cyclin-dependent kinase 15

PFTAIRE protein kinase 2

CDK15 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CDK15	Q96Q40	HSP90AA1	Homo sapiens	P07900	Anti Tag CoIP	33961781
Intra	CDK15	Q96Q40	FKBP5	Homo sapiens	Q13451	Lumier	25036637
Intra	CDK15	Q96Q40	FKBP5	Homo sapiens	Q13451	Anti Tag CoIP	33961781
Intra	CDK15	Q96Q40	FKBP5	Homo sapiens	Q13451	TAP	23602568
Intra	CDK15	Q96Q40	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	22939624
Intra	CDK15	Q96Q40	HSP90AB1	Homo sapiens	P08238	Lumier	22939624

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Amyotrophic Lateral Sclerosis 2, Juvenile

ALS2	Als, Juvenile
Alsj	Amyotrophic Lateral Sclerosis Type 2
Amyotrophic Lateral Sclerosis 2	Amyotrophic Lateral Sclerosis Type 2, Juvenile
Amyotrophic Lateral Sclerosis Juvenile	Amyotrophic Lateral Sclerosis Juvenile 2
Sclerosis, Lateral, Amyotrophic, Type Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02365	CDK15 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CDK15	RGD	RGD:1306205
Macaca mulatta	CDK15	VGNC	VGNC:70951
Felis catus	CDK15	VGNC	VGNC:60696
Bos taurus	CDK15	VGNC	VGNC:106681
Canis familiaris	CDK15	VGNC	VGNC:39047
Mus musculus	CDK15	MGD	MGI:3583944
Others	CDK15	NCBI

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