SLC2A4 - solute carrier family 2 member 4 Gene

Homo sapiens

Also known as GLUT4

Gene ID: 6517 | Gene type: protein coding

About SLC2A4

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,281,718-7,288,257 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 289 orthologues and 13 paralogues. Biased expression in heart (RPKM 32.2), fat (RPKM 24.5) and 6 other tissues.

Summary

This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of Insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of Insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM). [provided by RefSeq, Jul 2008]

SLC2A4 Products(1)

mRNA	Protein	Name
NM_001042.3	NP_001033.1	solute carrier family 2, facilitated glucose transporter member 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables D-glucose transmembrane transporter activity	IDA IDA: Inferred from direct assay	25004245	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19478182	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to insulin stimulus	IDA IDA: Inferred from direct assay	12556481	GOA
acts upstream of or within glucose homeostasis	IDA IDA: Inferred from direct assay	14562105	GOA
involved in glucose homeostasis	IDA IDA: Inferred from direct assay	17003346	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in clathrin-coated vesicle	IDA IDA: Inferred from direct assay	19478182	GOA
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	14562105	GOA
located in insulin-responsive compartment	IDA IDA: Inferred from direct assay	19590752	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	12556481	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	31112275	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12556481	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	12467732	GOA
located in vesicle membrane	IDA IDA: Inferred from direct assay	14562105	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC2A4 Protein Structure

Sugar_tr

0
100
200
300
400
509 a.a.

Protein Preferred Names

Protein Names

solute carrier family 2, facilitated glucose transporter member 4

GLUT-4	glucose transporter type 4, insulin-responsive
insulin-responsive glucose transporter type 4	solute carrier family 2 (facilitated glucose transporter), member 4

Related Diseases

Diseases

Alias

Glucose Metabolism Disease

Glucose Metabolism Disorders

Disorder Of Glucose Metabolism

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Diabetes Mellitus, Non-Insulin-Dependent	Type 2 Diabetes
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Inherited Metabolic Disorder

Inborn Errors Of Metabolism	Inborn Metabolism Disorder
Metabolic Hereditary Disorder	Inborn Error Of Metabolism
Inborn Metabolic Disorder	Metabolism, Inborn Errors

Liver Cirrhosis

Cirrhosis	Cirrhosis Of Liver
CIRRH	Cryptogenic Cirrhosis
Cirrhosis, Cryptogenic	Cirrhosis Nos

Prediabetes Syndrome

Impaired Glucose Tolerance	Prediabetes
Prediabetic State	IGT
Igt - [Impaired Glucose Tolerance]	Impaired Glucose Tolerance With Unspecified Complication
Impaired Glucose Tolerance Without Complication	Abnormal Glucose Tolerance

Abdominal Obesity-Metabolic Syndrome 1

Metabolic Syndrome X	Metabolic Syndrome
AOMS1	Dysmetabolic Syndrome X
Metabolic Disease	Abdominal Obesity Metabolic Syndrome

Diabetic Encephalopathy

Hyperinsulinism

Hyperinsulinemia

Acquired Metabolic Disease

Acanthosis Nigricans

Keratosis Nigricans

Abdominal Obesity-Metabolic Syndrome Quantitative Trait Locus 2

Abdominal Obesity-Metabolic Syndrome	Abdominal Obesity Metabolic Syndrome
Metabolic Syndrome X	Aoms2
Aoms1

Myopathy

Muscular Diseases

Myopathies

Overnutrition

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Diabetes Mellitus

Diabetes

Glucose Intolerance

Glucose: Intolerance	Glucose: Malabsorption
Malabsorption Of Glucose	Impaired Glucose Tolerance

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
BMIQ11	Obesity Bmiq11
Obesity, Early-Onset	Obesity , Susceptibility To
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Carbohydrate Metabolic Disorder

Inborn Errors Of Carbohydrate Metabolism	Disorder Of Carbohydrate Metabolism
Carbohydrate Metabolism, Inborn Errors	Disorder Of Carbohydrate Transport And Metabolism
Inborn Carbohydrate Metabolism Disorder	Inborn Carbohydrate Metabolic Disorder
Carbohydrate Metabolism Disorder	Carbohydrate Metabolism Disorders
Disorders Of Carbohydrate Metabolism	Congenital Disorders Of Carbohydrate Metabolism
Inherited Disorders Of Carbohydrate Metabolism

Gestational Diabetes

Gestational Diabetes Mellitus	GDM
Diabetes Mellitus Arising In Pregnancy	Maternal Gestational Diabetes Mellitus
Diabetes Mellitus, Gestational	Diabetes Mellitus, Pregnancy Related
Diabetes, Pregnancy-Induced	Diabetes Gestational
Diabetes, Gestational	Diabetes Of Pregnancy
Gdm - [Gestational Diabetes Mellitus]	Gestational Diabetes Mellitus Nos
Gestational Diabetes Complicating Pregnancy, Childbirth, Or The Puerperium

Leptin Deficiency Or Dysfunction

Morbid Obesity	Obesity Due To Congenital Leptin Deficiency
LEPD	Congenital Leptin Deficiency
Obesity, Morbid	Obesity, Morbid, Due To Leptin Deficiency
Severe Obesity	Obesity, Morbid, Nonsyndromic 1
Leptin Deficiency	Obesity, Severe, Due To Leptin Deficiency
Morbid Obesity Due To Leptin Deficiency	Obesity Morbid
Leptin Dysfunction	Leptin

Clear Cell Adenocarcinoma

Mesonephroma	Water-Clear Cell Adenocarcinoma
Adenocarcinoma, Clear Cell	Malignant Mesonephroma
Mesonephroid Clear Cell Carcinoma	Mesonephroma, Malignant
Water-Clear Cell Carcinoma	Wolffian Duct Neoplasm
Adenocarcinoma Clear Cell	Mesonephric Tumor

Adult Syndrome

Acro-Dermato-Ungual-Lacrimal-Tooth Syndrome	Acro Dermato Ungual Lacrimal Tooth Syndrome
Pigment Anomaly-Ectrodactyly-Hypodontia Syndrome	Acro-Dermato-Ungual-Lacrimal-Tooth Syndrome
Adult

Polycystic Ovary Syndrome

Polycystic Ovarian Syndrome	Pcos
Polycystic Ovaries	Stein-Leventhal Syndrome
Multicystic Ovaries	Polycystic Ovarian Disease
Polycystic Ovary	Sclerocystic Ovaries
Sclerocystic Ovary Syndrome	Stein-Leventhal Synd.
Cystic Disease Of Ovaries	Cystic Disease Of Ovary
Pco	Pcod
Sclerocystic Ovarian Degeneration	Polycystic Ovary Syndrome, Susceptibility To
Pcos - [Polycystic Ovary Syndrome]	Polycystic Ovary Nos
Pco - [Polycystic Ovary]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13170	SLC2A4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13171	Slc2a4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13172	Slc2a4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13173	SLC2A4RG Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SLC2A4	VGNC	VGNC:53442
Bos taurus	SLC2A4	VGNC	VGNC:34801
Rattus norvegicus	SLC2A4	RGD	RGD:2711
Macaca mulatta	SLC2A4	VGNC	VGNC:77449
Felis catus	SLC2A4	VGNC	VGNC:65303
Mus musculus	SLC2A4	MGD	MGI:95758
Others	SLC2A4	NCBI

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