SLC5A4 - solute carrier family 5 member 4 Gene

Homo sapiens

Also known as SAAT1; SGLT3; DJ90G24.4

Gene ID: 6527 | Gene type: protein coding

About SLC5A4

Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:32,218,464-32,355,063 (from NCBI)

This gene has 1 transcript (splice variant), 553 orthologues and 11 paralogues. Biased expression in small intestine (RPKM 7.8), duodenum (RPKM 6.8) and 3 other tissues.

Summary

Predicted to enable glucose:sodium symporter activity and proton transmembrane transporter activity. Predicted to be involved in sodium ion transport. Predicted to act upstream of or within proton transmembrane transport. Predicted to be active in plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

SLC5A4 Products(1)

mRNA	Protein	Name
NM_014227.3	NP_055042.1	solute carrier family 5 member 4

SLC5A4 Protein Structure

SSF

0
200
400
600
659 a.a.

Protein Preferred Names

Protein Names

solute carrier family 5 member 4

Na(+)/glucose cotransporter 3

SLC5A4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SLC5A4	Q9NY91	TMEM237	Homo sapiens	Q96Q45-2	Y2H Array	32296183
Intra	SLC5A4	Q9NY91	TMEM237	Homo sapiens	Q96Q45-2	Y2H Prey Pooling	32296183
Intra	SLC5A4	Q9NY91	MS4A3	Homo sapiens	Q96HJ5	Y2H Array	32296183
Intra	SLC5A4	Q9NY91	MS4A3	Homo sapiens	Q96HJ5	Y2H Prey Pooling	32296183
Intra	SLC5A4	Q9NY91	GOLM1	Homo sapiens	Q8NBJ4	Y2H Array	32296183
Intra	SLC5A4	Q9NY91	GOLM1	Homo sapiens	Q8NBJ4	Y2H Prey Pooling	32296183
Intra	SLC5A4	Q9NY91	KASH5	Homo sapiens	Q8N6L0	Y2H Array	32296183
Intra	SLC5A4	Q9NY91	KASH5	Homo sapiens	Q8N6L0	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Balanoposthitis

Balanitis Due To Infection

Diabetes Mellitus, Ketosis-Prone

Diabetic Ketoacidosis	KPD
Diabetes Mellitus, Ketosis-Prone, Susceptibility To	Ketosis-Prone Diabetes Mellitus
Diabetes Mellitus, Insulin-Dependent	Diabetic Ketoacidosis Nos
Dka - [Diabetic Ketoacidosis] Nos	Dka - [Diabetic Ketoacidosis] Without Coma
Dka - [Diabetic Ketoacidosis] With Coma

Balanitis

Urinary Tract Infection

Urinary Tract Infections	Uti
Urinary Tract Infection Nos	Uti - [Urinary Tract Infection]
Uti Nos - [Urinary Tract Infection Nos]	Urosepsis Nos
E Coli Uti	E Coli Urinary Tract Infection
Escherichia Coli Uti

Vulvitis

Vulvitis Nos	Inflammation Of Vulva
Edeitis

Alcoholic Ketoacidosis

Renal Glucosuria

Renal Glycosuria	Familial Renal Glucosuria
GLYS	Glys1
Glycosuria, Renal	Glucosuria, Renal
Renal Diabetes	Familial Renal Glycosuria
Sglt2 Deficiency	Gly
Diabetes Renal

Vulvovaginitis

Vulvo-Vaginitis

Penile Disease

Penile Diseases

Silent Myocardial Infarction

Kidney Hypertrophy

Hypertrophy Of Kidney

Vulvovaginal Candidiasis

Candidiasis Of Vulva And Vagina	Candidiasis, Vulvovaginal
Candidal Vulvovaginitis	Candidal: Cervix
Monilial Vulvovaginitis	Candidiasis Vulvovaginal

Pyelitis

Pancreatic Colloid Cystadenoma

Mucinous Cystadenoma Of Pancreas

Peripheral Artery Disease

Peripheral Arterial Disease

Peripheral Arterial Diseases

Nasopharyngitis

Chronic Nasopharyngitis

Chronic Rhinopharyngitis

Glucose Metabolism Disease

Glucose Metabolism Disorders

Disorder Of Glucose Metabolism

Carbohydrate Metabolic Disorder

Inborn Errors Of Carbohydrate Metabolism	Disorder Of Carbohydrate Metabolism
Carbohydrate Metabolism, Inborn Errors	Disorder Of Carbohydrate Transport And Metabolism
Inborn Carbohydrate Metabolism Disorder	Inborn Carbohydrate Metabolic Disorder
Carbohydrate Metabolism Disorder	Carbohydrate Metabolism Disorders
Disorders Of Carbohydrate Metabolism	Congenital Disorders Of Carbohydrate Metabolism
Inherited Disorders Of Carbohydrate Metabolism

Autoimmune Disease Of Endocrine System

Inherited Metabolic Disorder

Inborn Errors Of Metabolism	Inborn Metabolic Disorder
Inborn Metabolism Disorder	Metabolic Hereditary Disorder
Inborn Error Of Metabolism	Metabolism, Inborn Errors

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Fanconi Syndrome

Infantile Nephropathic Cystinosis	Adult Fanconi Syndrome
Congenital Fanconi Syndrome	De Toni-Fanconi Syndrome
Fanconi-De Toni Syndrome	Lignac-Fanconi Syndrome
Fanconi Renotubular Syndrome	Primary Fanconi Renotubular Syndrome
De Toni-Debre-Fanconi Syndrome	Adult Fanconi Anemia
Detoni Fanconi Syndrome	Fanconi-De-Toni Syndrome
Primary Fanconi Syndrome	Detoni-Debre-Fanconi Syndrome
Primary Fanconi Renal Syndrome	Fanconi Anemia
Cystinosis, Infantile Nephropathic	Fanconi-Bickel Syndrome
Renal Fanconi Syndrome	Lowe-Bickel Syndrome

Lactic Acidosis

Acidosis, Lactic

Acidosis Lactic

Lipid Metabolism Disorder

Dyslipidemia	Disorder Of Fatty Acid Metabolism
Lipid Metabolism Disorders	Fatty Acid Metabolism Disorder
Disorder Of Lipid Metabolism	Abnormality Of Lipid Metabolism
Lipid Metabolism, Inborn Errors	Dyslipidemias
Disorders Of Lipid Metabolism	Congenital Disorders Of Lipid Metabolism
Inherited Disorders Of Lipid Metabolism

Maturity-Onset Diabetes Of The Young

MODY	Maturity Onset Diabetes Mellitus In Young
Mason-Type Diabetes	Mason Type Diabetes
Maturity Onset Diabetes Of The Young	Mody Syndrome
Diabetes Of The Young, Maturity-Onset

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13290	SLC5A4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SLC5A4	VGNC	VGNC:77612
Rattus norvegicus	SLC5A4	RGD	RGD:1306923
Mus musculus	SLC5A4	MGD	MGI:1927848
Canis familiaris	SLC5A4	VGNC	VGNC:46447
Bos taurus	SLC5A4	VGNC	VGNC:34907

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