Nherf2 - NHERF family PDZ scaffold protein 2 Gene

Mus musculus

Also known as Sip1; Octs2; Sip-1; Tka-1; E3karp; Sryip1; NHERF-2; Slc9a3r2; 0610011L07Rik; 1200011K07Rik; 2010007A20Rik

Gene ID: 65962 | Gene type: protein coding

About Nherf2

Summary

Enables Phosphatase binding activity. Acts upstream of or within negative regulation of phosphatidylinositol 3-kinase signaling and sensory perception of sound. Located in several cellular components, including apical plasma membrane; nucleus; and stereocilium. Is expressed in cochlea epithelium and organ of Corti. Orthologous to human SLC9A3R2 (SLC9A3 regulator 2). [provided by Alliance of Genome Resources, Apr 2022]

Nherf2 Products(3)

mRNA	Protein	Name
NM_001357796.1	NP_001344725.1	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 isoform C
NM_023055.2	NP_075542.2	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 isoform A
NM_023449.3	NP_075938.2	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 isoform B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphatase binding	IPI IPI: Inferred from physical interaction	16456542	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10410901	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI IGI: Inferred from genetic interaction	16456542	MGI
acts upstream of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI IGI: Inferred from genetic interaction	16456542	MGI
acts upstream of or within sensory perception of sound	IMP IMP: Inferred from mutant phenotype	24920589	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	12169661	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	10410901	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10410901	MGI
located in stereocilium	IDA IDA: Inferred from direct assay	24920589	MGI
located in stereocilium bundle	IDA IDA: Inferred from direct assay	24920589	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

Na(+)/H(+) exchange regulatory cofactor NHE-RF2

NHE3 kinase A regulatory protein E3KARP	SRY-interacting protein 1
sodium-hydrogen exchanger regulatory factor 2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
tyrosine kinase activator protein 1

Nherf2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Nherf2	Q9JHL1	Pten	Mus musculus	O08586	Pull Down	16456542
Intra	Nherf2	Q9JHL1	Pdgfrb	Mus musculus	P05622	Chromatography	16456542
Intra	Nherf2	Q9JHL1	Pdgfrb	Mus musculus	P05622	Pull Down	16456542

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09283	NHERF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nherf2	NCBI	NCBI:9351

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