NHERF2 - NHERF family PDZ scaffold protein 2 Gene

Homo sapiens

Also known as SIP1; OCTS2; SIP-1; TKA-1; E3KARP; NHE3RF2; NHERF-2; SLC9A3R2

Gene ID: 9351 | Gene type: protein coding

About NHERF2

Summary

This gene encodes a member of the NHERF family of PDZ scaffolding proteins. These proteins mediate many cellular processes by binding to and regulating the membrane expression and protein-protein interactions of membrane receptors and transport proteins. The encoded protein plays a role in intestinal sodium absorption by regulating the activity of the sodium/hydrogen exchanger 3, and may also regulate the cystic fibrosis transmembrane regulator (CFTR) ion channel. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

NHERF2 Products(5)

mRNA	Protein	Name
NM_001130012.3	NP_001123484.1	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 isoform a
NM_001252073.2	NP_001239002.1	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 isoform c
NM_001252075.2	NP_001239004.1	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 isoform d
NM_001252076.2	NP_001239005.1	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 isoform e
NM_004785.6	NP_004776.3	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 isoform b

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	17242191	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	22587461	GOA
enables phosphatase binding	IPI IPI: Inferred from physical interaction	16456542	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9054412	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	16456542	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	11786550	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

Na(+)/H(+) exchange regulatory cofactor NHE-RF2

NHE3 kinase A regulatory protein E3KARP

NHERF2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NHERF2	Q15599	YAP1	Homo sapiens	P46937	Anti Tag CoIP	33961781
Intra	NHERF2	Q15599	YAP1	Homo sapiens	P46937	TAP	27173435
Intra	NHERF2	Q15599	YAP1	Homo sapiens	P46937	Pull Down	16166090
Intra	NHERF2	Q15599	CFTR	Homo sapiens	P13569	Pull Down	12369822
Intra	NHERF2	Q15599	DLGAP4	Homo sapiens	Q9Y2H0-1	Validated Y2H	32296183
Intra	NHERF2	Q15599	DLGAP4	Homo sapiens	Q9Y2H0-1	Y2H Array	32296183
Intra	NHERF2	Q15599	DLGAP4	Homo sapiens	Q9Y2H0-1	Y2H Prey Pooling	32296183
Cross	NHERF2	Q15599	nleH1-1	Escherichia coli O157:H7	Q8X831	Far-WB	20618342
Cross	NHERF2	Q15599	nleH1-1	Escherichia coli O157:H7	Q8X831	IF	20618342
Cross	NHERF2	Q15599	nleH1-1	Escherichia coli O157:H7	Q8X831	Protein Array	20618342
Cross	NHERF2	Q15599	nleH1-1	Escherichia coli O157:H7	Q8X831	Anti Tag CoIP	20618342
Intra	NHERF2	Q15599	TRAF4	Homo sapiens	Q9BUZ4	Y2H Prey Pooling	32296183
Intra	NHERF2	Q15599	TRAF4	Homo sapiens	Q9BUZ4	Validated Y2H	32296183
Intra	NHERF2	Q15599	SRY	Homo sapiens	Q05066	Anti Bait CoIP	9054412
Intra	NHERF2	Q15599	SRY	Homo sapiens	Q05066	Far-WB	9054412
Intra	NHERF2	Q15599	SRY	Homo sapiens	Q05066	Pull Down	9054412
Intra	NHERF2	Q15599	SRY	Homo sapiens	Q05066	Y2H	9054412
Intra	NHERF2	Q15599	SRY	Homo sapiens	Q05066	Pull Down	16166090
Intra	NHERF2	Q15599	PODXL	Homo sapiens	O00592	Anti Tag CoIP	33961781
Intra	NHERF2	Q15599	PTEN	Homo sapiens	P60484	Filter Binding	16456542
Intra	NHERF2	Q15599	PTEN	Homo sapiens	P60484	Pull Down	16456542
Intra	NHERF2	Q15599	PTEN	Homo sapiens	P60484	Anti Tag CoIP	16456542
Intra	NHERF2	Q15599	PTEN	Homo sapiens	P60484	Anti Bait CoIP	16456542
Intra	NHERF2	Q15599	WWP2	Homo sapiens	O00308	Y2H Prey Pooling	32296183
Intra	NHERF2	Q15599	WWP2	Homo sapiens	O00308	Y2H Array	32296183
Intra	NHERF2	Q15599	LPAR2	Homo sapiens	Q9HBW0	Pull Down	16203867
Cross	NHERF2	Q15599	Sry	Mus musculus	Q05738	IF	16166090
Intra	NHERF2	Q15599	SLC26A3	Homo sapiens	P40879	Pull Down	12369822
Cross	NHERF2	Q15599	map	Escherichia coli O127:H6	B7UMA0	Protein Array	20618342
Cross	NHERF2	Q15599	map	Escherichia coli O127:H6	B7UMA0	Far-WB	20618342
Cross	NHERF2	Q15599	map	Escherichia coli O127:H6	B7UMA0	IF	20618342
Cross	NHERF2	Q15599	b7ur60_eco27	Escherichia coli O127:H6	B7UR60	Far-WB	20618342
Cross	NHERF2	Q15599	b7ur60_eco27	Escherichia coli O127:H6	B7UR60	Anti Tag CoIP	20618342
Cross	NHERF2	Q15599	b7ur60_eco27	Escherichia coli O127:H6	B7UR60	IF	20618342
Cross	NHERF2	Q15599	mGluR1a	Rattus norvegicus	Q9R0W0	Protein Array	19027007

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09283	NHERF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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