2. Gene
  3. CAPN15 - calpain 15 Gene

CAPN15 - calpain 15 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as OGIN; SOLH

Gene ID: 6650 | Gene type: protein coding

About CAPN15

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:527,712-554,636 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 236 orthologues, 20 paralogues and is associated with 1 phenotype. Broad expression in colon (RPKM 5.1), spleen (RPKM 4.7) and 25 other tissues.

Summary

This gene encodes a protein containing zinc-finger-like repeats and a calpain-like protease domain. The encoded protein may function as a transcription factor, RNA-binding protein, or in protein-protein interactions during visual system development. [provided by RefSeq, Jul 2008]

CAPN15 Products(1)

mRNA Protein Name
NM_005632.3 NP_005623.1 calpain-15
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAPN15 Protein Structure

zf-RanBP

zf-RanBP: Zn-finger in Ran binding protein and others (5 - 30)

zf-RanBP

zf-RanBP: Zn-finger in Ran binding protein and others (145 - 170)

zf-RanBP

zf-RanBP: Zn-finger in Ran binding protein and others (412 - 438)

Peptidase_C2

Peptidase_C2: Calpain family cysteine protease (488 - 792)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1086 a.a.
Protein Preferred Names Protein Names

calpain-15

small optic lobes homolog

CAPN15 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CAPN15 O75808 TRAF2 Homo sapiens Q12933
Validated Y2H
32296183
Intra
CAPN15 O75808 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
Intra
CAPN15 O75808 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
Intra
CAPN15 O75808 RNF216 Homo sapiens Q9NWF9
Y2H Array
32296183
Intra
CAPN15 O75808 RNF216 Homo sapiens Q9NWF9
Y2H Prey Pooling
32296183
Intra
CAPN15 O75808 RNF216 Homo sapiens Q9NWF9
Validated Y2H
32296183
Intra
CAPN15 O75808 DAZAP2 Homo sapiens Q15038
Y2H Prey Pooling
32296183
Intra
CAPN15 O75808 DAZAP2 Homo sapiens Q15038
Validated Y2H
32296183
Intra
CAPN15 O75808 DAZAP2 Homo sapiens Q15038
Y2H Array
32296183
Intra
CAPN15 O75808 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra
CAPN15 O75808 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra
CAPN15 O75808 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Oculogastrointestinal Neurodevelopmental Syndrome

OGIN

Oculogastrointestinal-Neurodevelopmental Syndrome

Ogin Syndrome
Coloboma, Ocular, Autosomal Dominant

Coloboma, Ocular

Coloboma Of Iris, Choroid, And Retina

Coi

Coloboma, Uveoretinal

COAD

Ocular Coloboma

Uveoretinal Coloboma

Chronic Obstructive Airway Disease
Coloboma Of Macula

Coloboma

Congenital Ocular Coloboma

Microphthalmia, Isolated, With Coloboma

Agenesis Of Macula

Hereditary Macular Coloboma

Ocular Coloboma

Coloboma Of Eye

Macular Coloboma

Uveoretinal Coloboma
Spastic Hemiplegia

Spastic Hemiplegic Cerebral Palsy

Hemiplegic Cerebral Palsy

Congenital Hemiplegia

Hemiplegic Infantile Cerebral Palsy

Cerebral Palsy Spastic Hemiplegic

Spastic Hemiplegia Cerebral Palsy

Hemiplegia, Spastic
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Microphthalmia

Microphthalmos

Isolated Anophthalmia-Microphthalmia Syndrome

Isolated Microphthalmia-Anophthalmia-Coloboma

Simple Microphthalmos

Clinical Anophthalmia

Isolated Anophthalmia - Microphthalmia

Isolated Pure Microphthalmia

Mac Spectrum

Microphthalmia-Anophthalmia-Coloboma Spectrum

Primitive Anophthalmia

Globe Of Eye Small

Small Eyeball

Hypoplasia Of Eye

Isolated Nanophthalmos

Rudimentary Eye

Dysplasia Of Eye
Heart Disease

Heart Failure

Congenital Heart Disease

Heart Diseases

Congenital Heart Defects

Congenital Heart Defect

Heart Malformation

Congenital Anomaly Of Heart

Heart Defect

Heart-Congenital Defect

Congenital Heart Disorder

Heart Defects Congenital

Heart Defects, Congenital

Heart Defects

Heart Disease, Congenital

Disease, Heart, Congenital

Congestive Heart Failure
Focal Hand Dystonia

Organic Writer'S Cramp

Dystonia, Focal, Task-Specific
Spastic Cerebral Palsy

Palsy, Cerebral, Spastic

Infantile Hemiplegia Nos

Postnatal Infantile Hemiplegia Nos

Congenital Spastic Hemiplegia

Spastic Hemiplegic Cerebral Palsy

Congenital Hemiplegia Nos

Hemiplegic Cerebral Palsy

Hemiplegic Infantile Cerebral Palsy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01888 CAPN15 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CAPN15 VGNC VGNC:26746
Macaca mulatta CAPN15 VGNC VGNC:70470
Mus musculus CAPN15 MGD MGI:1355075
Canis familiaris CAPN15 VGNC VGNC:38703
Rattus norvegicus CAPN15 RGD RGD:1306514
Felis catus CAPN15 VGNC VGNC:60353