BOK - BCL2 family apoptosis regulator BOK Gene

Homo sapiens

Also known as BOKL; BCL2L9

Gene ID: 666 | Gene type: protein coding

About BOK

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:241,551,393-241,574,131 (from NCBI)

This gene has 2 transcripts (splice variants), 265 orthologues and 8 paralogues. Broad expression in fat (RPKM 69.1), liver (RPKM 18.4) and 16 other tissues.

Summary

The protein encoded by this gene belongs to the BCL2 family, members of which form homo- or heterodimers, and act as anti- or proapoptotic regulators that are involved in a wide variety of cellular processes. Studies in rat show that this protein has restricted expression in reproductive tissues, interacts strongly with some antiapoptotic BCL2 proteins, not at all with proapoptotic BCL2 proteins, and induces Apoptosis in transfected cells. Thus, this protein represents a proapoptotic member of the BCL2 family. [provided by RefSeq, Sep 2011]

BOK Products(1)

mRNA	Protein	Name
NM_032515.5	NP_115904.1	bcl-2-related ovarian killer protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15868100	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	20673843	GOA
involved in apoptotic process	IDA IDA: Inferred from direct assay	15102863	GOA
involved in intrinsic apoptotic signaling pathway by p53 class mediator	IMP IMP: Inferred from mutant phenotype	15102863	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	16302269	GOA
involved in positive regulation of execution phase of apoptosis	IMP IMP: Inferred from mutant phenotype	20673843	GOA
involved in regulation of autophagy	IMP IMP: Inferred from mutant phenotype	24113155	GOA
involved in regulation of chorionic trophoblast cell proliferation	IDA IDA: Inferred from direct assay	19942931	GOA
involved in regulation of granulosa cell apoptotic process	IMP IMP: Inferred from mutant phenotype	20673843	GOA
involved in release of cytochrome c from mitochondria	IDA IDA: Inferred from direct assay	27505430	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	27505430	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15868100	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	16302269	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	27505430	GOA
located in membrane	IDA IDA: Inferred from direct assay	19942931	GOA
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	24113155	GOA
located in mitochondrial membrane	IDA IDA: Inferred from direct assay	15868100	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	15102863	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16302269	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BOK Protein Structure

Bcl-2

0
100
200
212 a.a.

Protein Preferred Names

Protein Names

bcl-2-related ovarian killer protein

BCL2 related ovarian killer

BOK Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	BOK	Q9UMX3	PECAM1	Homo sapiens	P16284	Validated Y2H	32814053
Intra	BOK	Q9UMX3	PECAM1	Homo sapiens	P16284	Y2H Pooling	32814053
Intra	BOK	Q9UMX3	PECAM1	Homo sapiens	P16284	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Retinitis Pigmentosa 71

RP71	Retinitis Pigmentosa, Type 71

Myelodysplastic Syndrome

Myelodysplastic Syndromes	Myelodysplasia
MDS	Myelodysplastic Syndrome Included
Myelodysplastic Syndrome, Susceptibility To, Included	Myelodysplastic Syndrome, Somatic
Myelodysplastic Syndrome, Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01570	BOK Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	BOK	VGNC	VGNC:60146
Bos taurus	BOK	VGNC	VGNC:26538
Rattus norvegicus	BOK	RGD	RGD:70984
Mus musculus	BOK	MGD	MGI:1858494
Macaca mulatta	BOK	VGNC	VGNC:104511
Others	BOK	NCBI

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