Pycard - PYD and CARD domain containing Gene

Mus musculus

Also known as Asc; TNS1; masc; CARD5; TMS-1; 9130417A21Rik

Gene ID: 66824 | Gene type: protein coding

About Pycard

Summary

Enables identical protein binding activity and protein dimerization activity. Involved in several processes, including activation of cysteine-type endopeptidase activity; positive regulation of cytokine production; and regulation of defense response. Acts upstream of or within several processes, including defense response to Gram-positive bacterium; positive regulation of macromolecule metabolic process; and regulation of Autophagy. Located in cytosol; extracellular region; and nucleus. Part of inflammasome complex. Is expressed in several structures, including alimentary system; brain; heart; hemolymphoid system gland; and urinary system. Orthologous to human PYCARD (PYD and CARD domain containing). [provided by Alliance of Genome Resources, Apr 2022]

Pycard Products(2)

mRNA	Protein	Name
NM_023258.4	NP_075747.3	apoptosis-associated speck-like protein containing a CARD
NM_023258.4	NP_075747.3	apoptosis-associated speck-like protein containing a CARD

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	24407287	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15190255	MGI
enables protein dimerization activity	IMP IMP: Inferred from mutant phenotype	24407287	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in activation of cysteine-type endopeptidase activity	IMP IMP: Inferred from mutant phenotype	23302887	MGI
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	17008311	MGI
involved in activation of innate immune response	IMP IMP: Inferred from mutant phenotype	19158675	MGI
acts upstream of or within defense response to Gram-positive bacterium	IMP IMP: Inferred from mutant phenotype	30248149	MGI
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	15190255	MGI
acts upstream of interleukin-1 beta production	IGI IGI: Inferred from genetic interaction	22002608	MGI
acts upstream of or within interleukin-1 beta production	IGI IGI: Inferred from genetic interaction	19158679	MGI
acts upstream of macrophage cytokine production	IGI IGI: Inferred from genetic interaction	22002608	MGI
involved in macropinocytosis	IMP IMP: Inferred from mutant phenotype	21892172	MGI
involved in myeloid dendritic cell activation involved in immune response	IMP IMP: Inferred from mutant phenotype	21892172	MGI
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	21487011	MGI
involved in positive regulation of T cell migration	IMP IMP: Inferred from mutant phenotype	21892172	MGI
involved in positive regulation of actin filament polymerization	IMP IMP: Inferred from mutant phenotype	21892172	MGI
involved in positive regulation of activated T cell proliferation	IMP IMP: Inferred from mutant phenotype	21892172	MGI
involved in positive regulation of antigen processing and presentation of peptide antigen via MHC class II	IMP IMP: Inferred from mutant phenotype	21892172	MGI
involved in positive regulation of chemokine production	IMP IMP: Inferred from mutant phenotype	21487011	MGI
involved in positive regulation of defense response to virus by host	IMP IMP: Inferred from mutant phenotype	19158675	MGI
involved in positive regulation of inflammatory response	IDA IDA: Inferred from direct assay	27270401	MGI
involved in positive regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	27270401	MGI
acts upstream of or within positive regulation of interleukin-1 beta production	IGI IGI: Inferred from genetic interaction	22002608	MGI
acts upstream of or within positive regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	23997220	MGI
involved in positive regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	19158675	MGI
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	21892172	MGI
acts upstream of or within positive regulation of macrophage cytokine production	IGI IGI: Inferred from genetic interaction	22002608	MGI
involved in positive regulation of phagocytosis	IMP IMP: Inferred from mutant phenotype	21892172	MGI
involved in positive regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	21892172	MGI
involved in regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	21892172	MGI
acts upstream of or within regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	15190255	MGI
acts upstream of or within regulation of autophagy	IMP IMP: Inferred from mutant phenotype	24581500	MGI
acts upstream of or within regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	15190255	MGI
acts upstream of or within regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	22002608	MGI
involved in regulation of protein stability	IMP IMP: Inferred from mutant phenotype	21892172	MGI
acts upstream of or within response to bacterium	IMP IMP: Inferred from mutant phenotype	24581500	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of NLRP6 inflammasome complex	IDA IDA: Inferred from direct assay	34678144	MGI
part of canonical inflammasome complex	IDA IDA: Inferred from direct assay	30248149	MGI
located in cytosol	IDA IDA: Inferred from direct assay	11139337	MGI
located in extracellular region	IDA IDA: Inferred from direct assay	15190255	MGI
located in nucleus	IDA IDA: Inferred from direct assay	21892172	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

apoptosis-associated speck-like protein containing a CARD

PYD and CARD domain-containing protein

Pycard Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Pycard	Q9EPB4	Casp1	Mus musculus	P29452	Anti Bait CoIP	34589402
Intra	Pycard	Q9EPB4	Casp1	Mus musculus	P29452	GMS	22801494
Intra	Pycard	Q9EPB4	Casp1	Mus musculus	P29452	Cosedimentation	27993998
Intra	Pycard	Q9EPB4	Nlrp3	Mus musculus	Q8R4B8	IF	27993998
Intra	Pycard	Q9EPB4	Nlrp3	Mus musculus	Q8R4B8	Anti Bait CoIP	23143333
Intra	Pycard	Q9EPB4	Nlrp3	Mus musculus	Q8R4B8	Anti Bait CoIP	25605870
Intra	Pycard	Q9EPB4	Nlrp3	Mus musculus	Q8R4B8	Anti Bait CoIP	34589402
Intra	Pycard	Q9EPB4	Nlrp3	Mus musculus	Q8R4B8	Cosedimentation	27993998
Intra	Pycard	Q9EPB4	Nlrp3	Mus musculus	Q8R4B8	GMS	22801494

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11485	PYCARD Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pycard	NCBI	NCBI:29108

Name
Email *

	Sorry, but the email address you supplied was invalid.