Casp1 - caspase 1 Gene

Mus musculus

Also known as ICE; Il1bc

Gene ID: 12362 | Gene type: protein coding

About Casp1

Chromosome 9: 5,298,508-5,307,290 forward strand.GRCm39:CM001002.3

This gene has 5 transcripts (splice variants), 456 orthologues, 11 paralogues and is associated with 2 phenotypes. Biased expression in large intestine adult (RPKM 7.4), bladder adult (RPKM 2.2) and 13 other tissues.

Summary

Enables cysteine-type endopeptidase activity. Involved in several processes, including positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interleukin-1 beta production; and protein autoprocessing. Acts upstream of or within several processes, including membrane hyperpolarization; mitochondrial depolarization; and positive regulation of interleukin-1 alpha production. Located in extracellular region. Part of IPAF inflammasome complex. Is expressed in knee joint and metanephros. Orthologous to human CASP1 (Caspase 1). [provided by Alliance of Genome Resources, Apr 2022]

Casp1 Products(1)

mRNA	Protein	Name
NM_009807.2	NP_033937.2	caspase-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	18667412	MGI
enables peptidase activity	IDA IDA: Inferred from direct assay	18490713	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8670890	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in AIM2 inflammasome complex assembly	IDA IDA: Inferred from direct assay	23567559	MGI
involved in defense response to Gram-negative bacterium	IMP IMP: Inferred from mutant phenotype	29887864	MGI
involved in defense response to bacterium	IDA IDA: Inferred from direct assay	35705808	MGI
acts upstream of interleukin-1 alpha production	IMP IMP: Inferred from mutant phenotype	18490713	MGI
acts upstream of or within interleukin-1 beta production	IGI IGI: Inferred from genetic interaction	19158679	MGI
acts upstream of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	18490713	MGI
acts upstream of macrophage cytokine production	IMP IMP: Inferred from mutant phenotype	18490713	MGI
acts upstream of or within membrane hyperpolarization	IMP IMP: Inferred from mutant phenotype	23028046	MGI
acts upstream of or within mitochondrial depolarization	IMP IMP: Inferred from mutant phenotype	23028046	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	16585594	MGI
involved in positive regulation of cytokine production	IDA IDA: Inferred from direct assay	21147462	MGI
involved in positive regulation of inflammatory response	IDA IDA: Inferred from direct assay	27270401	MGI
acts upstream of or within positive regulation of interleukin-1 alpha production	IMP IMP: Inferred from mutant phenotype	18490713	MGI
involved in positive regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	21147462	MGI
acts upstream of or within positive regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	18490713	MGI
acts upstream of or within positive regulation of macrophage cytokine production	IMP IMP: Inferred from mutant phenotype	18490713	MGI
acts upstream of or within programmed necrotic cell death	IDA IDA: Inferred from direct assay	16429160	MGI
involved in protein autoprocessing	IDA IDA: Inferred from direct assay	21147462	MGI
involved in protein maturation	IDA IDA: Inferred from direct assay	32109412	MGI
acts upstream of or within protein processing	IDA IDA: Inferred from direct assay	11016935	MGI
acts upstream of or within protein processing	IMP IMP: Inferred from mutant phenotype	14663141	MGI
involved in pyroptotic inflammatory response	IDA IDA: Inferred from direct assay	21147462	MGI
acts upstream of or within pyroptotic inflammatory response	IMP IMP: Inferred from mutant phenotype	22002608	MGI
acts upstream of or within regulation of autophagy	IMP IMP: Inferred from mutant phenotype	24581500	MGI
acts upstream of or within regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	22297845	MGI
acts upstream of or within response to ATP	IMP IMP: Inferred from mutant phenotype	18490713	MGI
acts upstream of or within response to bacterium	IMP IMP: Inferred from mutant phenotype	24581500	MGI
acts upstream of or within response to hypoxia	IMP IMP: Inferred from mutant phenotype	14663141	MGI
acts upstream of or within response to lipopolysaccharide	IDA IDA: Inferred from direct assay	16301672	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of IPAF inflammasome complex	IDA IDA: Inferred from direct assay	21874021	MGI
is active in cytoplasm	IDA IDA: Inferred from direct assay	21147462	MGI
is active in cytosol	IDA IDA: Inferred from direct assay	35705808	MGI
located in extracellular region	IDA IDA: Inferred from direct assay	15190255	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Casp1 Protein Structure

CARD_CASP1-like

CASc

0
100
200
300
402 a.a.

Protein Preferred Names

Protein Names

caspase-1

CASP-1	IL-1 beta-converting enzyme
IL-1B converting enzyme	IL-1BC
interleukin-1 beta convertase	interleukin-1 beta-converting enzyme
p45

Casp1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Casp1	P29452	sctE1	Salmonella typhi	Q56134	Pull Down	10051653
Cross	Casp1	P29452	sctE1	Salmonella typhi	Q56134	CoIP	10051653
Intra	Casp1	P29452	Pycard	Mus musculus	Q9EPB4	Crosslink	27993998
Intra	Casp1	P29452	Pycard	Mus musculus	Q9EPB4	Anti Bait CoIP	25605870
Intra	Casp1	P29452	Pycard	Mus musculus	Q9EPB4	Anti Bait CoIP	27993998
Intra	Casp1	P29452	Nlrp3	Mus musculus	Q8R4B8	Crosslink	27993998

Cross: Cross-species interaction Intra: Intraspecies interaction

Casp1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81232	Caspase-1 Antibody	WB, ELISA, IHC-P, IHC-F, FC, ICC/IF	Human, Mouse, Rat,

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-N0842	Bevirimat	Inhibitor	99.80%	Phase 2

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-171006	IRF1-IN-1	Inhibitor	99.72%	Unkown
HY-171007	IRF1-IN-2		99.83%	Unkown
HY-150536	EP39	Inhibitor	/	Unkown
HY-RS01941	CASP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01942	Casp1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01943	Casp1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Casp1	NCBI	NCBI:834

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