Vps28 - vacuolar protein sorting 28 Gene

Mus musculus

Also known as CIIA; 1110014J03Rik; D730005C08Rik

Gene ID: 66914 | Gene type: protein coding

About Vps28

Summary

This gene encodes a protein which is thought to be a subunit of the ESCRT-I complex (endosomal complexes required for transport), which functions in the transport and sorting of proteins into subcellular vesicles. This complex can also be hijacked to facilitate the budding of enveloped viruses from the cell membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]

Vps28 Products(2)

mRNA	Protein	Name
NM_001305668.1	NP_001292597.1	vacuolar protein sorting-associated protein 28 homolog isoform 2
NM_025842.4	NP_080118.1	vacuolar protein sorting-associated protein 28 homolog isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14557248	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

vacuolar protein sorting-associated protein 28 homolog

ESCRT-I complex subunit VPS28

caspase-activated DNase inhibitor that interacts with ASK1

Vps28 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Vps28	Q9D1C8	MAP3K5	Homo sapiens	Q99683	Confocal	14557248
Cross	Vps28	Q9D1C8	MAP3K5	Homo sapiens	Q99683	Pull Down	14557248
Intra	Vps28	Q9D1C8	Dffb	Mus musculus	O54788	Anti Bait CoIP	14557248
Intra	Vps28	Q9D1C8	Dffb	Mus musculus	O54788	Pull Down	14557248
Intra	Vps28	Q9D1C8	Dffb	Mus musculus	O54788	Confocal	14557248
Intra	Vps28	Q9D1C8	Map3k5	Mus musculus	O35099	Anti Bait CoIP	14557248

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15681	VPS28 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Vps28	NCBI	NCBI:51160

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