2. Gene
  3. SPINT1 - serine peptidase inhibitor, Kunitz type 1 Gene

SPINT1 - serine peptidase inhibitor, Kunitz type 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HAI; HAI1; MANSC2

Gene ID: 6692 | Gene type: protein coding

About SPINT1

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:40,844,048-40,858,207 (from NCBI)

This gene has 11 transcripts (splice variants), 530 orthologues and 13 paralogues. Broad expression in placenta (RPKM 87.0), duodenum (RPKM 69.0) and 15 other tissues.

Summary

The protein encoded by this gene is a member of the Kunitz family of serine Protease Inhibitors. The protein is a potent inhibitor specific for HGF activator and is thought to be involved in the regulation of the proteolytic activation of HGF in injured tissues. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008]

SPINT1 Products(6)

mRNA Protein Name
NM_001032367.2 NP_001027539.1 kunitz-type protease inhibitor 1 isoform 2 precursor
NM_001386873.1 NP_001373802.1 kunitz-type protease inhibitor 1 isoform 1 precursor
NM_001386874.1 NP_001373803.1 kunitz-type protease inhibitor 1 isoform 3 precursor
NM_001386875.1 NP_001373804.1 kunitz-type protease inhibitor 1 isoform 4 precursor
NM_003710.4 NP_003701.1 kunitz-type protease inhibitor 1 isoform 2 precursor
NM_181642.3 NP_857593.1 kunitz-type protease inhibitor 1 isoform 1 precursor
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15713485 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPINT1 Protein Structure

MANEC

MANEC: MANEC domain (47 - 140)

Kunitz_BPTI

Kunitz_BPTI: Kunitz/Bovine pancreatic trypsin inhibitor domain (250 - 301)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (334 - 369)

Kunitz_BPTI

Kunitz_BPTI: Kunitz/Bovine pancreatic trypsin inhibitor domain (391 - 442)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 529 a.a.
Protein Preferred Names Protein Names

kunitz-type protease inhibitor 1

HAI-1

Recombinant SPINT1 Proteins

Cat. No. Product Name Accession Purity
HY-P73091 HAI-1 Protein, Human (His) O43278-2 (G36-V433) ≥95%

Related Diseases

Diseases Alias
Pulmonary Embolism And Infarction
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Ichthyosis, Congenital, Autosomal Recessive 11

Autosomal Recessive Congenital Ichthyosis 11

Ichthyosis With Hypotrichosis, Autosomal Recessive

Arih

Ichthyosis And Follicular Atrophoderma With Hypotrichosis And Hypohidrosis

Autosomal Recessive Ichthyosis With Hypotrichosis

ARCI11

Ifah

Hypotrichosis-Congenital Ichthyosis Syndrome

Ichthyosis-Follicular Atrophoderma-Hypotrichosis Syndrome

Ichthyosis-Follicular Atrophoderma-Hypotrichosis-Hypohidrosis Syndrome

Ichthyosis-Hypotrichosis Syndrome

Ifah Syndrome

Ihs
Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13685 SPINT1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SPINT1 RGD RGD:1303138
Felis catus SPINT1 VGNC VGNC:65640
Canis familiaris SPINT1 VGNC VGNC:46746
Bos taurus SPINT1 VGNC VGNC:35221
Mus musculus SPINT1 MGD MGI:1338033
Others SPINT1 NCBI