SPRR1A - small proline rich protein 1A Gene

Homo sapiens

Also known as SPRK

Gene ID: 6698 | Gene type: protein coding

About SPRR1A

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:152,984,081-152,985,814 (from NCBI)

This gene has 2 transcripts (splice variants), 62 orthologues and 20 paralogues. Restricted expression toward esophagus (RPKM 829.4).

Summary

A structural constituent of skin epidermis. Involved in keratinocyte differentiation and peptide cross-linking. Located in cornified envelope. [provided by Alliance of Genome Resources, Apr 2022]

SPRR1A Products(2)

mRNA	Protein	Name
NM_001199828.2	NP_001186757.1	cornifin-A
NM_005987.4	NP_005978.2	cornifin-A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10066784	GOA
enables structural constituent of skin epidermis	IDA IDA: Inferred from direct assay	7543090	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in keratinocyte differentiation	IDA IDA: Inferred from direct assay	10908733	GOA
involved in peptide cross-linking	IDA IDA: Inferred from direct assay	7543090	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cornified envelope	IDA IDA: Inferred from direct assay	7543090	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPRR1A Protein Structure

Cornifin

0
89 a.a.

Protein Preferred Names

Protein Names

cornifin-A

19 kDa pancornulin

SPRR1A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SPRR1A	P35321	GLIS1	Homo sapiens	Q8NBF1	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Progesterone-Receptor Positive Breast Cancer

Macular Degeneration, Age-Related, 13

Age Related Macular Degeneration 13	ARMD13
Macular Degeneration, Age-Related, 13, Susceptibility To	Macular Degeneration, Age-Related, Type 13

Autosomal Recessive Congenital Ichthyosis

Lamellar Ichthyosis	Congenital Ichthyosiform Erythroderma
Li	Congenital Nonbullous Ichthyosiform Erythroderma
Arci	Congenital Lamellar Ichthyosis
Nonbullous Congenital Ichthyosiform Erythroderma	Cie
Congenital Non-Bullous Ichthyosiform Erythroderma	Erythrodermic Ichthyosis
Nbcie	Ncie
Non-Bullous Congenital Ichthyosiform Erythroderma	Collodion Baby
Ichthyosis, Lamellar	Non Bullous Congenital Ichthyosiform Erythroderma
Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form	Ichthyosiform Erythroderma, Congenital, Nonbullous, 1
Collodion Baby Syndrome	Ichthyoses, Lamellar
Nbie	Nonbullous Ichthyosiform Erythroderma
Classic Lamellar Ichthyosis	Ichthyosiform Erythroderma Nonbullous Congenital
Ichthyosiform Erythroderma Congenital	Ichthyosis, Congenital, Autosomal Recessive
Ichthyosiform Erythroderma, Congenital	Collodion Fetus
Non-Bullous Ichthyosiform Erythroderma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13713	SPRR1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SPRR1A	MGD	MGI:106660
Rattus norvegicus	SPRR1A	RGD	RGD:1593163

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