2. Gene
  3. GLIS1 - GLIS family zinc finger 1 Gene

GLIS1 - GLIS family zinc finger 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 148979 | Gene type: protein coding

About GLIS1

Cytogenetic location: 1p32.3 Genomic coordinates (GRCh38): 1:53,506,239-53,739,164 (from NCBI)

This gene has 2 transcripts (splice variants), 196 orthologues and 14 paralogues. Low expression observed in reference dataset.

Summary

GLIS1 is a Gli (MIM 165220)-related Kruppel-like zinc finger protein that functions as an activator and repressor of transcription (Kim et al., 2002 [PubMed 12042312]).[supplied by OMIM, Mar 2008]

GLIS1 Products(5)

mRNA Protein Name
NM_001367484.1 NP_001354413.1 zinc finger protein GLIS1 isoform 2
NM_001390836.1 NP_001377765.1 zinc finger protein GLIS1 isoform 3
NM_001390837.1 NP_001377766.1 zinc finger protein GLIS1 isoform 2
NM_001390838.1 NP_001377767.1 zinc finger protein GLIS1 isoform 4
NM_147193.4 NP_671726.2 zinc finger protein GLIS1 isoform 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GLIS1 Protein Structure

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (249 - 275)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (278 - 305)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (322 - 346)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 620 a.a.
Protein Preferred Names Protein Names

zinc finger protein GLIS1

GLI-similar 1

GLIS1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
GLIS1 Q8NBF1 ZDHHC23 Homo sapiens Q8IYP9
Y2H Array
32296183
Intra
GLIS1 Q8NBF1 ZDHHC23 Homo sapiens Q8IYP9
Y2H Prey Pooling
32296183
Intra
GLIS1 Q8NBF1 SPRR1A Homo sapiens P35321
Y2H Prey Pooling
32296183
Intra
GLIS1 Q8NBF1 SPRR1A Homo sapiens P35321
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Venezuelan Equine Encephalitis

Venezuelan Equine Fever

Venezuelan Equine Encephalomyelitis

Encephalitis Venezuelan Equine

Encephalomyelitis, Venezuelan Equine

Venezuelan Encephalitis

Disorder Due To Venezuelan Equine Encephalitis Virus

Venezuelan Equine Encephalitis Virus Infection

Venezuelan Equine Encephalomyelitis Virus Disease
Myoclonic Epilepsy Associated With Ragged-Red Fibers

Merrf Syndrome

MERRF

Fukuhara Syndrome

Myoclonic Epilepsy Associated With Ragged Red Fibers

Myoencephalopathy Ragged-Red Fiber Disease

Myoclonic Epilepsy - Ragged Red Fibers

Myoclonus Epilepsy And Ragged Red Fibers

Myoclonus With Epilepsy And With Ragged Red Fibers

Myoclonic Epilepsy With Ragged Red Fibers

Myoclonic Epilepsy With Ragged-Red Fibers

Fukuhara Disease

Myoclonus Epilepsy Associated With Ragged-Red Fibres

Myoclonus With Epilepsy With Ragged Red Fibers
Congenital Hypothyroidism

Cretinism

Neonatal Hypothyroidism

Ch

Cht

Congenital Myxedema

Myxedema, Congenital

Endemic Cretinism

Congenital Iodine-Deficiency Syndrome

Fetal Iodine Deficiency Syndrome

Congenital Iodine-Deficiency Hypothyroidism Nos
Nephronophthisis

Medullary Cystic Disease

Medullary Cystic Kidney

Nph

Nphp

Kidney Disease, Cystic, Medullary
Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (20)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13901 GANT 61 ≥98.0% Unkown
HY-13282 GANT 58 Antagonist 99.62% Unkown
HY-P4860 Adropin (34-76) (human, mouse, rat) 99.87% Unkown
HY-122590 Glabrescione B Inhibitor 98.05% Unkown
HY-18366A RU-SKI 43 hydrochloride Inhibitor 99.55% Unkown
HY-N2112 Glaucocalyxin A 99.39% Unkown
HY-107551 GLI antagonist-1 Antagonist ≥95% Unkown
HY-W111144 T-1330 Inhibitor / Unkown
HY-18366 RU-SKI 43 Inhibitor / Unkown
HY-137567 Prostaglandin E1 ethanolamide Activator / Unkown
HY-143400 HSP70-IN-3 Inhibitor / Unkown
HY-147670 TPB15 / Unkown
HY-161459 GLI1-IN-1 / Unkown
HY-162273 Antibacterial agent 189 Inhibitor / Unkown
HY-N8270 Physalin H Inhibitor / Unkown
HY-RS05472 GLI1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS05473 Gli1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS05474 Gli1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS05480 GLIS1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-122017 Methoxy-SANT-2 Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus GLIS1 VGNC VGNC:62580
Mus musculus GLIS1 MGD MGI:2386723
Rattus norvegicus GLIS1 RGD RGD:1308030
Macaca mulatta GLIS1 VGNC VGNC:73034
Canis familiaris GLIS1 VGNC VGNC:49872
Bos taurus GLIS1 VGNC VGNC:29406