SRP19 - signal recognition particle 19 Gene

Homo sapiens

Gene ID: 6728 | Gene type: protein coding

About SRP19

Cytogenetic location: 5q22.2 Genomic coordinates (GRCh38): 5:112,861,287-112,898,371 (from NCBI)

This gene has 12 transcripts (splice variants) and 210 orthologues. Ubiquitous expression in thyroid (RPKM 11.2), bone marrow (RPKM 8.6) and 25 other tissues.

Summary

Enables 7S RNA binding activity. Contributes to ribosome binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition. Located in nucleolus. Part of signal recognition particle, endoplasmic reticulum targeting. [provided by Alliance of Genome Resources, Apr 2022]

SRP19 Products(5)

mRNA	Protein	Name
NM_001204193.2	NP_001191122.1	signal recognition particle 19 kDa protein isoform 2
NM_001204194.2	NP_001191123.1	signal recognition particle 19 kDa protein isoform 3
NM_001204196.2	NP_001191125.1	signal recognition particle 19 kDa protein isoform 4
NM_001204199.2	NP_001191128.1	signal recognition particle 19 kDa protein isoform 6
NM_003135.3	NP_003126.1	signal recognition particle 19 kDa protein isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 7S RNA binding	IDA IDA: Inferred from direct assay	17434535	GOA
enables RNA binding	IPI IPI: Inferred from physical interaction	17434535	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24700861	GOA
contributes to ribosome binding	IDA IDA: Inferred from direct assay	27899666	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleolus	IDA IDA: Inferred from direct assay	10618370	GOA
part of signal recognition particle	IDA IDA: Inferred from direct assay	27899666	GOA
part of signal recognition particle, endoplasmic reticulum targeting	IDA IDA: Inferred from direct assay	18089836	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRP19 Protein Structure

SRP19

0
100
144 a.a.

Protein Preferred Names

Protein Names

signal recognition particle 19 kDa protein

signal recognition particle 19kD

SRP19 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SRP19	P09132	SRP68	Homo sapiens	Q9UHB9	Anti Tag CoIP	35271311
Intra	SRP19	P09132	SRP68	Homo sapiens	Q9UHB9	X-Ray Diffraction	24700861
Intra	SRP19	P09132	SRP68	Homo sapiens	Q9UHB9	GMS	24700861

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Severe Congenital Neutropenia

Congenital Neutropenia	Neutropenia, Severe Congenital
Congenital Agranulocytosis	Infantile Genetic Agranulocytosis
Kostmann Disease	Kostmann'S Agranulocytosis
Kostmann'S Syndrome	Severe Infantile Genetic Neutropenia

Shwachman-Diamond Syndrome 1

Shwachman-Diamond Syndrome	Shwachman Syndrome
Shwachman-Bodian-Diamond Syndrome	Sds
Pancreatic Insufficiency And Bone Marrow Dysfunction	Shwachman-Bodian Syndrome
SDS1	Lipomatosis Of Pancreas, Congenital
Congenital Lipomatosis Of Pancreas	Shwachman-Diamond Type Metaphyseal Dysplasia
Metaphyseal Chondrodysplasia, Shwachman Type	Shwachman-Diamond-Oski Syndrome

Dental Fluorosis

Mottled Teeth	Intrinsic Enamel Discolouration Of Fluorosis
Mottling Of Enamel	Fluorosis, Dental
Dental Fluorosis, Acquired

Immunodeficiency 51

IMD51	Candf5
Candidiasis, Familial, 5	Candidiasis, Familial, 5, Formerly
Candf5, Formerly	Familial Candidiasis 5
Candidiasis Familial 5 Autosomal Recessive	Candidiasis Familial Chronic Mucocutaneous Autosomal Recessive
Chronic Mucocutaneous Candidiasis 5

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13772	SRP19 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SRP19	VGNC	VGNC:56002
Rattus norvegicus	SRP19	RGD	RGD:1308437
Felis catus	SRP19	VGNC	VGNC:97644
Mus musculus	SRP19	MGD	MGI:1913634
Bos taurus	SRP19	VGNC	VGNC:55145

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