SRP68 - signal recognition particle 68 Gene

Homo sapiens

Gene ID: 6730 | Gene type: protein coding

About SRP68

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:76,038,785-76,072,517 (from NCBI)

This gene has 13 transcripts (splice variants) and 210 orthologues. Ubiquitous expression in thyroid (RPKM 29.4), esophagus (RPKM 22.8) and 25 other tissues.

Summary

This gene encodes a subunit of the signal recognition particle (SRP). The SRP is a ribonucleoprotein complex that transports secreted and membrane proteins to the endoplasmic reticulum for processing. The complex includes a 7S RNA and six protein subunits. The encoded protein is the 68kDa component of the SRP, and forms a heterodimer with the 72kDa subunit that is required for SRP function. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and three pseudogenes of this gene are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, May 2012]

SRP68 Products(3)

mRNA	Protein	Name
NM_001260502.2	NP_001247431.1	signal recognition particle subunit SRP68 isoform 2
NM_001260503.2	NP_001247432.1	signal recognition particle subunit SRP68 isoform 3
NM_014230.4	NP_055045.2	signal recognition particle subunit SRP68 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 7S RNA binding	IMP IMP: Inferred from mutant phenotype	27899666	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16672232	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	27899666	GOA
contributes to ribosome binding	IMP IMP: Inferred from mutant phenotype	27899666	GOA
enables signal recognition particle binding	IPI IPI: Inferred from physical interaction	17254600	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	18089836	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of signal recognition particle	IDA IDA: Inferred from direct assay	27899666	GOA
part of signal recognition particle, endoplasmic reticulum targeting	IDA IDA: Inferred from direct assay	18089836	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

signal recognition particle subunit SRP68

signal recognition particle 68 kDa protein

Related Diseases

Diseases

Alias

Bladder Transitional Cell Papilloma

Bladder Papilloma	Transitional Cell Papilloma Of Bladder
Urinary Bladder Urothelial Papilloma	Urothelial Papilloma
Bladder Urothelial Papilloma

Smith-Magenis Syndrome

SMS	Chromosome 17p11.2 Deletion Syndrome
17p11.2 Microdeletion Syndrome	17p11.2 Monosomy
Chromosome 17p Deletion Syndrome	Del(17)
P11.2	17p- Syndrome
Deletion 17p Syndrome	Partial Monosomy 17p

Immunodeficiency 51

IMD51	Candf5
Candidiasis, Familial, 5	Candidiasis, Familial, 5, Formerly
Candf5, Formerly	Familial Candidiasis 5
Candidiasis Familial 5 Autosomal Recessive	Candidiasis Familial Chronic Mucocutaneous Autosomal Recessive
Chronic Mucocutaneous Candidiasis 5

Bladder Papillary Transitional Cell Neoplasm

Urinary Bladder Papillary Urothelial Neoplasm

Bladder Papillary Urothelial Neoplasm

Urinary Tract Papillary Transitional Cell Benign Neoplasm

Inverted Papilloma Of Urinary Tract	Papillary Transitional Cell Neoplasm Of The Urinary Tract
Urinary Tract Inverted Papilloma	Inverted Urothelial Papilloma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13774	SRP68 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SRP68	VGNC	VGNC:77883
Mus musculus	SRP68	MGD	MGI:1917447
Rattus norvegicus	SRP68	RGD	RGD:1305376
Felis catus	SRP68	VGNC	VGNC:65684
Bos taurus	SRP68	VGNC	VGNC:35286
Canis familiaris	SRP68	VGNC	VGNC:46808

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