2. Gene
  3. Mfn1 - mitofusin 1 Gene

Mfn1 - mitofusin 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as HR2; mKIAA4032; D3Ertd265e; 2310002F04Rik; 6330416C07Rik

Gene ID: 67414 | Gene type: protein coding

About Mfn1

Summary

Predicted to enable GTPase activity and identical protein binding activity. Involved in mitochondrial fusion and positive regulation of mitochondrial membrane potential. Located in mitochondrion. Is expressed in embryo; heart; and placenta. Orthologous to human MFN1 (mitofusin 1). [provided by Alliance of Genome Resources, Apr 2022]

Mfn1 Products(1)

mRNA Protein Name
NM_024200.5 NP_077162.2 mitofusin-1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12527753 MGI
Biological Process GO Annotation Evidence Reference Source
involved in mitochondrial fusion IGI
IGI: Inferred from genetic interaction
15899901 MGI
acts upstream of or within mitochondrial fusion IMP
IMP: Inferred from mutant phenotype
12527753 MGI
involved in mitochondrial fusion IMP
IMP: Inferred from mutant phenotype
15899901 MGI
involved in positive regulation of mitochondrial membrane potential IGI
IGI: Inferred from genetic interaction
15899901 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mitofusin-1

transmembrane GTPase MFN1

Mfn1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Cross
Mfn1 Q811U4 LRRK2 Homo sapiens Q5S007
Confocal
24282027
Cross
Mfn1 Q811U4 LRRK2 Homo sapiens Q5S007
Anti Tag CoIP
24282027
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-150031 MFI8 Inhibitor 99.44% Unkown
HY-126124 AP39 95.98% Unkown
HY-P3429A SAMβA TFA Inhibitor 99.13% Unkown
HY-P3429 SAMβA Inhibitor / Unkown
HY-P5891 TAT-SAMβA Antagonist / Unkown
HY-RS08383 MFN1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mfn1 NCBI NCBI:55669