SSRP1 - structure specific recognition protein 1 Gene

Homo sapiens

Also known as FACT; T160; FACT80

Gene ID: 6749 | Gene type: protein coding

About SSRP1

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:57,325,988-57,335,892 (from NCBI)

This gene has 5 transcripts (splice variants), 232 orthologues and 20 paralogues. Ubiquitous expression in lymph node (RPKM 33.5), ovary (RPKM 32.7) and 25 other tissues.

Summary

The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the Anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. [provided by RefSeq, Jul 2008]

SSRP1 Products(1)

mRNA	Protein	Name
NM_003146.3	NP_003137.1	FACT complex subunit SSRP1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16902406	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in nucleosome disassembly	IDA IDA: Inferred from direct assay	16902406	GOA
involved in regulation of chromatin organization	IDA IDA: Inferred from direct assay	27467129	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of FACT complex	IPI IPI: Inferred from physical interaction	16902406	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9489704	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SSRP1 Protein Structure

SSrecog

Rtt106

HMG_box

0
200
400
600
709 a.a.

Protein Preferred Names

Protein Names

FACT complex subunit SSRP1

FACT 80 kDa subunit

SSRP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SSRP1	Q08945	SUPT16H	Homo sapiens	Q9Y5B9	Anti Bait CoIP	19214185
Intra	SSRP1	Q08945	SUPT16H	Homo sapiens	Q9Y5B9	Anti Tag CoIP	33961781
Intra	SSRP1	Q08945	SUPT16H	Homo sapiens	Q9Y5B9	Anti Tag CoIP	28514442
Intra	SSRP1	Q08945	SUPT16H	Homo sapiens	Q9Y5B9	TAP	24981860
Intra	SSRP1	Q08945	SUPT16H	Homo sapiens	Q9Y5B9	Anti Bait CoIP	16902406
Intra	SSRP1	Q08945	SUPT16H	Homo sapiens	Q9Y5B9	Anti Tag CoIP	35271311
Intra	SSRP1	Q08945	H2BC21	Homo sapiens	Q16778	Crosslink	30021884
Intra	SSRP1	Q08945	H2BC21	Homo sapiens	Q16778	Anti Tag CoIP	35271311
Intra	SSRP1	Q08945	CSNK2A1	Homo sapiens	P68400	Anti Tag CoIP	28514442
Intra	SSRP1	Q08945	CSNK2A1	Homo sapiens	P68400	Anti Tag CoIP	35271311
Intra	SSRP1	Q08945	MCM7	Homo sapiens	P33993	Anti Tag CoIP	35271311
Intra	SSRP1	Q08945	MCM7	Homo sapiens	P33993	Anti Tag CoIP	28514442
Intra	SSRP1	Q08945	MCM2	Homo sapiens	P49736	TAP	24981860
Intra	SSRP1	Q08945	MCM2	Homo sapiens	P49736	Anti Tag CoIP	28514442
Intra	SSRP1	Q08945	MCM2	Homo sapiens	P49736	Anti Tag CoIP	35271311
Intra	SSRP1	Q08945	MCM2	Homo sapiens	P49736	Anti Bait CoIP	16902406
Intra	SSRP1	Q08945	MCM6	Homo sapiens	Q14566	Anti Tag CoIP	35271311
Intra	SSRP1	Q08945	MCM6	Homo sapiens	Q14566	Anti Bait CoIP	16902406
Intra	SSRP1	Q08945	MCM6	Homo sapiens	Q14566	Anti Tag CoIP	28514442
Intra	SSRP1	Q08945	MCM4	Homo sapiens	P33991	Anti Bait CoIP	16902406
Intra	SSRP1	Q08945	MCM4	Homo sapiens	P33991	Anti Tag CoIP	28514442
Intra	SSRP1	Q08945	MCM4	Homo sapiens	P33991	Anti Tag CoIP	33961781
Intra	SSRP1	Q08945	MCM4	Homo sapiens	P33991	Anti Tag CoIP	16902406
Intra	SSRP1	Q08945	MCM4	Homo sapiens	P33991	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Lupus Erythematosus

Lupus	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus, Systemic
Subacute Cutaneous Lupus	Le - [Lupus Erythematosus]

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13818	SSRP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SSRP1	MGD	MGI:107912
Felis catus	SSRP1	VGNC	VGNC:65710
Canis familiaris	SSRP1	VGNC	VGNC:46841
Rattus norvegicus	SSRP1	RGD	RGD:621143
Bos taurus	SSRP1	VGNC	VGNC:35323
Macaca mulatta	SSRP1	VGNC	VGNC:77891

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