2. Gene
  3. MCM7 - minichromosome maintenance complex component 7 Gene

MCM7 - minichromosome maintenance complex component 7 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MCM2; CDC47; P85MCM; P1CDC47; PNAS146; PPP1R104; P1.1-MCM3

Gene ID: 4176 | Gene type: protein coding

About MCM7

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,092,728-100,101,397 (from NCBI)

This gene has 13 transcripts (splice variants), 192 orthologues and 8 paralogues. Ubiquitous expression in bone marrow (RPKM 53.3), lymph node (RPKM 33.2) and 24 other tissues.

Summary

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of Other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding Enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

MCM7 Products(3)

mRNA Protein Name
NM_001278595.2 NP_001265524.1 DNA replication licensing factor MCM7 isoform 2
NM_005916.5 NP_005907.3 DNA replication licensing factor MCM7 isoform 1
NM_182776.3 NP_877577.1 DNA replication licensing factor MCM7 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
contributes to DNA helicase activity IDA
IDA: Inferred from direct assay
9305914 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9705868 GOA
contributes to single-stranded DNA binding IDA
IDA: Inferred from direct assay
25661590 GOA
Biological Process GO Annotation Evidence Reference Source
involved in DNA damage response IMP
IMP: Inferred from mutant phenotype
15538388 GOA
involved in DNA unwinding involved in DNA replication IDA
IDA: Inferred from direct assay
22474384 GOA
involved in regulation of phosphorylation IMP
IMP: Inferred from mutant phenotype
15538388 GOA
Cellular Component GO Annotation Evidence Reference Source
part of CMG complex IPI
IPI: Inferred from physical interaction
22474384 GOA
part of MCM complex IDA
IDA: Inferred from direct assay
17296731 GOA
part of MCM complex IMP
IMP: Inferred from mutant phenotype
15538388 GOA
part of MCM complex IPI
IPI: Inferred from physical interaction
22540012 GOA
NOT located in nucleolus IDA
IDA: Inferred from direct assay
21383955 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21383955 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MCM7 Protein Structure

MCM_N

MCM_N: MCM N-terminal domain (11 - 165)

MCM

MCM: MCM2/3/5 family (322 - 640)

  • 0
  • 200
  • 400
  • 600
  • 719 a.a.
Protein Preferred Names Protein Names

DNA replication licensing factor MCM7

CDC47 homolog

MCM7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
MCM7 P33993 CCDC102B Homo sapiens Q68D86
Y2H Array
25416956
Intra
MCM7 P33993 CCDC102B Homo sapiens Q68D86
Y2H Prey Pooling
25416956
Intra
MCM7 P33993 UBQLN1 Homo sapiens Q9UMX0-2
Y2H Prey Pooling
25416956
Intra
MCM7 P33993 UBQLN1 Homo sapiens Q9UMX0-2
Validated Y2H
25416956
Intra
MCM7 P33993 UBQLN1 Homo sapiens Q9UMX0-2
Y2H Array
25416956
Intra
MCM7 P33993 MBIP Homo sapiens Q9NS73-5
Y2H Array
25416956
Cross
MCM7 P33993 E6 Human papillomavirus P03126
Pull Down
9705868
Cross
MCM7 P33993 E6 Human papillomavirus P03126
Pull Down
14675634
Cross
MCM7 P33993 E6 Human papillomavirus P06463
Pull Down
9705868
Intra
MCM7 P33993 INTS6 Homo sapiens Q9UL03
Anti Bait CoIP
17310990
Intra
MCM7 P33993 INTS6 Homo sapiens Q9UL03
Pull Down
17310990
Intra
MCM7 P33993 KIFC3 Homo sapiens Q9BVG8
Validated Y2H
25416956
Intra
MCM7 P33993 TRIM54 Homo sapiens Q9BYV2
Validated Y2H
25416956
Intra
MCM7 P33993 MIPOL1 Homo sapiens Q8TD10
Validated Y2H
25416956
Intra
MCM7 P33993 FKBP5 Homo sapiens Q13451
Lumier
25036637
Intra
MCM7 P33993 SSRP1 Homo sapiens Q08945
Anti Bait CoIP
16902406
Intra
MCM7 P33993 MCM5 Homo sapiens P33992
Anti Tag CoIP
23764002
Intra
MCM7 P33993 MCM5 Homo sapiens P33992
Protein Array
15232106
Intra
MCM7 P33993 MCM5 Homo sapiens P33992
Anti Tag CoIP
33961781
Intra
MCM7 P33993 MCM2 Homo sapiens P49736
Anti Bait CoIP
23764002
Intra
MCM7 P33993 MCM2 Homo sapiens P49736
TAP
17296731
Intra
MCM7 P33993 MCM2 Homo sapiens P49736
Anti Tag CoIP
23764002
Intra
MCM7 P33993 MCM6 Homo sapiens Q14566
Anti Bait CoIP
23764002
Intra
MCM7 P33993 MCM6 Homo sapiens Q14566
TAP
17296731
Intra
MCM7 P33993 MCM6 Homo sapiens Q14566
Anti Bait CoIP
17296731
Intra
MCM7 P33993 MCM4 Homo sapiens P33991
Anti Bait CoIP
23764002
Intra
MCM7 P33993 MCM4 Homo sapiens P33991
Anti Bait CoIP
24299456
Intra
MCM7 P33993 MCM4 Homo sapiens P33991
TAP
17296731
Intra
MCM7 P33993 MCM4 Homo sapiens P33991
Anti Bait CoIP
17296731
Intra
MCM7 P33993 UBB Homo sapiens P0CG47
Anti Bait CoIP
17310990
Intra
MCM7 P33993 MYC Homo sapiens P01106
Y2H
17314511
Intra
MCM7 P33993 MYC Homo sapiens P01106
Anti Tag CoIP
17314511
Intra
MCM7 P33993 PLK1 Homo sapiens P53350
Pull Down
15654075
Intra
MCM7 P33993 PLK1 Homo sapiens P53350
CoIP
15654075
Intra
MCM7 P33993 CDKN1C Homo sapiens P49918
Y2H Array
16289477
Intra
MCM7 P33993 CDKN1C Homo sapiens P49918
Pull Down
16289477
Intra
MCM7 P33993 CDKN1B Homo sapiens P46527
Y2H Fragment Pooling
16289477
Intra
MCM7 P33993 GOLGA2 Homo sapiens Q08379
Y2H Array
25416956
Intra
MCM7 P33993 GOLGA2 Homo sapiens Q08379
Validated Y2H
25416956
Intra
MCM7 P33993 LYN Homo sapiens P07948-1
Anti Tag CoIP
23764002
Intra
MCM7 P33993 LYN Homo sapiens P07948-1
Protein Kinase Assay
23764002
Cross
MCM7 P33993 E6 Human papillomavirus P06462
Pull Down
9705868
Intra
MCM7 P33993 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
25416956
Intra
MCM7 P33993 TRIM27 Homo sapiens P14373
Y2H Array
25416956
Intra
MCM7 P33993 MCMBP Homo sapiens Q9BTE3
Anti Bait CoIP
17296731
Intra
MCM7 P33993 MCMBP Homo sapiens Q9BTE3
Y2H Array
25416956
Intra
MCM7 P33993 MCMBP Homo sapiens Q9BTE3
Y2H Prey Pooling
25416956
Intra
MCM7 P33993 MCMBP Homo sapiens Q9BTE3
Anti Bait CoIP
22540012
Intra
MCM7 P33993 MCMBP Homo sapiens Q9BTE3
TAP
17296731
Intra
MCM7 P33993 MCMBP Homo sapiens Q9BTE3
Anti Bait CoIP
24299456
Intra
MCM7 P33993 LYN Homo sapiens P07948
Anti Bait CoIP
23764002
Intra
MCM7 P33993 SMC1A Homo sapiens Q14683
Anti Tag CoIP
16438930
Intra
MCM7 P33993 SMC1A Homo sapiens Q14683
Anti Bait CoIP
16438930
Intra
MCM7 P33993 AK8 Homo sapiens Q96MA6
Y2H Array
25416956
Intra
MCM7 P33993 AK8 Homo sapiens Q96MA6
Y2H Array
31515488
Intra
MCM7 P33993 NAB2 Homo sapiens Q15742
Validated Y2H
25416956
Intra
MCM7 P33993 SP2 Homo sapiens Q02086
Y2H Prey Pooling
25416956
Intra
MCM7 P33993 MCMBP Homo sapiens Q9BTE3-2
Validated Y2H
26871637
Intra
MCM7 P33993 MCMBP Homo sapiens Q9BTE3-2
Validated Y2H
32296183
Intra
MCM7 P33993 MCMBP Homo sapiens Q9BTE3-2
Y2H Array
26871637
Intra
MCM7 P33993 MCMBP Homo sapiens Q9BTE3-2
Y2H Array
32296183
Intra
MCM7 P33993 MCMBP Homo sapiens Q9BTE3-2
Y2H Prey Pooling
26871637
Intra
MCM7 P33993 MCMBP Homo sapiens Q9BTE3-2
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Meier-Gorlin Syndrome 1

Meier-Gorlin Syndrome

Ear, Patella, Short Stature Syndrome

Microtia, Absent Patellae, Micrognathia Syndrome

MGORS1

Eps

Ear-Patella-Short Stature Syndrome

Ear Patella Short Stature Syndrome

Microtia Absent Patellae Micrognathia Syndrome

Meier-Gorlin Syndrome, Type 1
Follicular Adenoma

Follicular Adenoma Of The Thyroid Gland

Thyroid Follicular Adenoma

Adenoma Follicular

Follicular Thyroid Adenoma

Thyroid Gland Follicular Adenoma
Deafness, Autosomal Dominant 70

DFNA70

Autosomal Dominant Nonsyndromic Deafness 70

Autosomal Dominant Deafness 70

Deafness, Autosomal Dominant, 70
Retinoblastoma

RB

Trilateral Retinoblastoma

RB1

Retinoblastoma, Trilateral

Neuroblastoma Of Retina

Rb - Retinoblastoma

Eye Cancer, Retinoblastoma

Retinal Cancer

Retinal Tumor

Glioma, Retinal

Non-Hereditary Retinoblastoma

Childhood Cancer Retinoblastoma

Malignant Neoplasm Of Retina

Retinal Neoplasms
Cervix Endometriosis

Endometriosis Of Cervix

Cervical Endometriosis
Cardiomyopathy, Familial Hypertrophic, 6

Hypertrophic Cardiomyopathy 6

CMH6

Familial Hypertrophic Cardiomyopathy With Wolff-Parkinson-White Syndrome

Cardiomyopathy, Familial Hypertrophic 6

Cardiomyopathy, Hypertrophic 6

Cardiomyopathy, Hypertrophic, Familial, Type 6
Meier-Gorlin Syndrome 5

MGORS5

Meier-Gorlin Syndrome, Type 5
Immunodeficiency 7

Tcr-Alpha-Beta-Positive T-Cell Deficiency

IMD7

T-Cell Receptor-Alpha/Beta Deficiency

Immunodeficiency 7, Tcr-Alpha/Beta Deficient

Tcr-Alpha/Beta Deficiency

Tcr-Alpha-Beta+ T-Cell Deficiency

T-Cell Receptor Alpha/Beta Deficiency
Anus Cancer

Anal Cancer

Anal Carcinoma

Malignant Anal Tumor

Cancer Of The Anus

Malignant Neoplasm Of Anus

Anus Neoplasms
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Medulloblastoma Predisposition Syndrome

Medulloblastoma, Somatic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Neuroectodermal Tumors, Primitive

Medulloblastomas

Desmoplastic Medulloblastoma

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08240 MCM7 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta MCM7 VGNC VGNC:74686
Felis catus MCM7 VGNC VGNC:68218
Mus musculus MCM7 MGD MGI:1298398
Canis familiaris MCM7 VGNC VGNC:43087
Rattus norvegicus MCM7 RGD RGD:1303018
Bos taurus MCM7 VGNC VGNC:31313