STC1 - stanniocalcin 1 Gene

Homo sapiens

Also known as STC

Gene ID: 6781 | Gene type: protein coding

About STC1

Cytogenetic location: 8p21.2 Genomic coordinates (GRCh38): 8:23,841,929-23,854,806 (from NCBI)

This gene has 2 transcripts (splice variants), 277 orthologues and 1 paralogue. Broad expression in endometrium (RPKM 33.6), thyroid (RPKM 19.7) and 14 other tissues.

Summary

This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers. [provided by RefSeq, Jul 2008]

STC1 Products(1)

mRNA	Protein	Name
NM_003155.3	NP_003146.1	stanniocalcin-1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	26195635	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in bone development	IDA IDA: Inferred from direct assay	16377640	GOA
involved in chondrocyte proliferation	IDA IDA: Inferred from direct assay	16377640	GOA
involved in endothelial cell morphogenesis	IDA IDA: Inferred from direct assay	14500721	GOA
involved in growth plate cartilage axis specification	IDA IDA: Inferred from direct assay	16377640	GOA
involved in intracellular calcium ion homeostasis	IDA IDA: Inferred from direct assay	8700837	GOA
involved in negative regulation of calcium ion transport	IDA IDA: Inferred from direct assay	8700837	GOA
acts upstream of positive effect negative regulation of cell migration	IDA IDA: Inferred from direct assay	17032941	GOA
involved in negative regulation of endothelial cell migration	IDA IDA: Inferred from direct assay	14500721	GOA
involved in negative regulation of renal phosphate excretion	IDA IDA: Inferred from direct assay	8700837	GOA
involved in positive regulation of calcium ion import	IDA IDA: Inferred from direct assay	17032941	GOA
involved in regulation of cardiac muscle cell contraction	IDA IDA: Inferred from direct assay	12663264	GOA
involved in regulation of monoatomic anion transport	IDA IDA: Inferred from direct assay	16377640	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12663264	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12663264	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STC1 Protein Structure

Stanniocalcin

0
100
200
247 a.a.

Protein Preferred Names

Protein Names

stanniocalcin-1

Recombinant STC1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71338	STC1/Stanniocalcin-1 Protein, Human (HEK293, His)	P52823-1 (T18-A247)	≥95%

Related Diseases

Diseases

Alias

Fibrosarcoma

Neoplasms, Fibrous Tissue	Fibrocytic Tumor
Fibrosarcoma Of Soft Tissue	Fibrous Tissue Neoplasm

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16228	Stc1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13903	STC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	STC1	VGNC	VGNC:46895
Bos taurus	STC1	VGNC	VGNC:35377
Felis catus	STC1	VGNC	VGNC:65767
Rattus norvegicus	STC1	RGD	RGD:621776
Macaca mulatta	STC1	VGNC	VGNC:84120
Mus musculus	STC1	MGD	MGI:109131
Others	STC1	NCBI

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