STK10 - serine/threonine kinase 10 Gene

Homo sapiens

Also known as LOK; PRO2729

Gene ID: 6793 | Gene type: protein coding

About STK10

Cytogenetic location: 5q35.1 Genomic coordinates (GRCh38): 5:172,042,079-172,188,224 (from NCBI)

This gene has 16 transcripts (splice variants), 202 orthologues and 35 paralogues. Broad expression in spleen (RPKM 23.3), bone marrow (RPKM 21.8) and 23 other tissues.

Summary

This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. [provided by RefSeq, Jul 2008]

STK10 Products(1)

mRNA	Protein	Name
NM_005990.4	NP_005981.3	serine/threonine-protein kinase 10

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	18239682	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12639966	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	18239682	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	18239682	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	12639966	GOA
involved in regulation of lymphocyte migration	IMP IMP: Inferred from mutant phenotype	19255442	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	19255442	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STK10 Protein Structure

Pkinase

PKK

0
200
400
600
800
968 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase 10

lymphocyte-oriented kinase

Recombinant STK10 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73282	LOK Protein, Human (His)	O94804 (R18-E317)	≥95%

Related Diseases

Diseases

Alias

Testicular Germ Cell Tumor

Male Germ Cell Tumor	Testicular Teratoma
TGCT	Mgct
Male Germ Cell Tumor, Somatic	Spermatocytic Seminoma, Somatic
Embryonal Cell Carcinoma	Seminoma
Spermatocytic Seminoma	Germ Cell Tumors, Somatic
Testicular Tumor, Somatic	Non-Seminomatous Germ Cell Tumor Of Testis
Non-Dysgerminomatous Germ Cell Tumor Of Testis	Testicular Non Seminomatous Germ Cell Tumor
Testicular Non-Dysgerminomatous Germ Cell Tumor	Teratoma Of The Testis
Endodermal Sinus Tumor	Nonseminomatous Germ Cell Tumors
Teratoma Testicular	Germ Cell Tumor, Somatic
Embryonal Carcinoma Cell	Yolk Sac Tumor
Malignant Testicular Non-Seminomatous Germ Cell Tumor	Testicular Non-Seminomatous Germ Cell Tumor
Teratoma Of Testis	Nonseminomatous Germ Cell Tumor

Germ Cell Tumor

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-132868	SLK/STK10-IN-1	Inhibitor	99.34%	Unkown
HY-108333	SB-633825	Inhibitor	98.52%	Unkown
HY-150782	UNC-CA359	Inhibitor	/	Unkown
HY-RS13920	STK10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	STK10	MGD	MGI:1099439
Rattus norvegicus	STK10	RGD	RGD:3779
Bos taurus	STK10	VGNC	VGNC:35384
Macaca mulatta	STK10	VGNC	VGNC:81582
Canis familiaris	STK10	VGNC	VGNC:46904
Felis catus	STK10	VGNC	VGNC:97646
Others	STK10	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.