SLK/STK10-IN-1

Name: SLK/STK10-IN-1
Brand: MedChemExpress
SKU: HY-132868
Rating: 5.0 (2 reviews)

Cat. No.: HY-132868 Purity: 99.34%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

SLK/STK10-IN-1 is a potent and selective inhibitor of SLK and STK10 with nanomolar potency.

For research use only. We do not sell to patients.

SLK/STK10-IN-1 Chemical Structure

CAS No. : 264210-49-3

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 253	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 253	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 230	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 370	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 660	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 990	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1500	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 2 publication(s) in Google Scholar

2 Publications Citing Use of MCE SLK/STK10-IN-1

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Biological Activity
Purity & Documentation
References
Customer Review

Description

SLK/STK10-IN-1 is a potent and selective inhibitor of SLK and STK10 with nanomolar potency.

Molecular Weight

328.75

Formula

C₁₇H₁₃ClN₂O₃

CAS No.

264210-49-3

Appearance

Solid

Color

White to yellow

SMILES

O=C(C(NC1=CC=CC(Cl)=C1)=C2C3=CC=CC=C3OC)NC2=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (304.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0418 mL	15.2091 mL	30.4182 mL
5 mM	0.6084 mL	3.0418 mL	6.0837 mL
10 mM	0.3042 mL	1.5209 mL	3.0418 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.60 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.34%

Select Batch:

Data Sheet (276 KB) SDS (251 KB)

COA (256 KB) HNMR (148 KB) RP-HPLC (235 KB)

Handling Instructions (2659 KB)

References

[1]. Serafim RAM, et al. Discovery of a Potent Dual SLK/STK10 Inhibitor Based on a Maleimide Scaffold. J Med Chem. 2021 Sep 23;64(18):13259-13278. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.0418 mL	15.2091 mL	30.4183 mL	76.0456 mL
	5 mM	0.6084 mL	3.0418 mL	6.0837 mL	15.2091 mL
	10 mM	0.3042 mL	1.5209 mL	3.0418 mL	7.6046 mL
	15 mM	0.2028 mL	1.0139 mL	2.0279 mL	5.0697 mL
	20 mM	0.1521 mL	0.7605 mL	1.5209 mL	3.8023 mL
	25 mM	0.1217 mL	0.6084 mL	1.2167 mL	3.0418 mL
	30 mM	0.1014 mL	0.5070 mL	1.0139 mL	2.5349 mL
	40 mM	0.0760 mL	0.3802 mL	0.7605 mL	1.9011 mL
	50 mM	0.0608 mL	0.3042 mL	0.6084 mL	1.5209 mL
	60 mM	0.0507 mL	0.2535 mL	0.5070 mL	1.2674 mL
	80 mM	0.0380 mL	0.1901 mL	0.3802 mL	0.9506 mL
	100 mM	0.0304 mL	0.1521 mL	0.3042 mL	0.7605 mL

SLK/STK10-IN-1 Related Classifications

Others

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SLK/STK10-IN-1264210-49-3OthersInhibitorinhibitorinhibit

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SLK/STK10-IN-1

Customer Review

SLK/STK10-IN-1 Related Antibodies

2 Publications Citing Use of MCE SLK/STK10-IN-1

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

SLK/STK10-IN-1 Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

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SAFETY DATA SHEET (SDS)

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