2. Gene
  3. SULT1A1 - sulfotransferase family 1A member 1 Gene

SULT1A1 - sulfotransferase family 1A member 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PST; STP; STP1; P-PST; ST1A1; ST1A3; TSPST1; ts-PST; P-PST 1; HAST1/HAST2

Gene ID: 6817 | Gene type: protein coding

About SULT1A1

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:28,605,258-28,623,375 (from NCBI)

This gene has 5 transcripts (splice variants), 757 orthologues and 12 paralogues. Broad expression in duodenum (RPKM 44.2), liver (RPKM 36.4) and 22 other tissues.

Summary

Sulfotransferase Enzymes catalyze the sulfate conjugation of many Hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic Enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable Enzyme activity. Multiple alternatively spliced variants that encode two isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

SULT1A1 Products(10)

mRNA Protein Name
NM_001055.4 NP_001046.2 sulfotransferase 1A1 isoform a
NM_001394421.1 NP_001381350.1 sulfotransferase 1A1 isoform a
NM_001394422.1 NP_001381351.1 sulfotransferase 1A1 isoform a
NM_001394423.1 NP_001381352.1 sulfotransferase 1A1 isoform a
NM_001394424.1 NP_001381353.1 sulfotransferase 1A1 isoform a
NM_001394425.1 NP_001381354.1 sulfotransferase 1A1 isoform a
NM_177529.3 NP_803565.1 sulfotransferase 1A1 isoform a
NM_177530.4 NP_803566.1 sulfotransferase 1A1 isoform a
NM_177534.4 NP_803878.1 sulfotransferase 1A1 isoform a
NM_177536.5 NP_803880.2 sulfotransferase 1A1 isoform c
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables 3'-phosphoadenosine 5'-phosphosulfate binding IDA
IDA: Inferred from direct assay
12471039 GOA
enables aryl sulfotransferase activity IDA
IDA: Inferred from direct assay
12471039 GOA
enables flavonol 3-sulfotransferase activity IDA
IDA: Inferred from direct assay
20056724 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables steroid sulfotransferase activity IDA
IDA: Inferred from direct assay
16221673 GOA
enables sulfotransferase activity IDA
IDA: Inferred from direct assay
19548878 GOA
Biological Process GO Annotation Evidence Reference Source
involved in 3'-phosphoadenosine 5'-phosphosulfate metabolic process IDA
IDA: Inferred from direct assay
12471039 GOA
involved in estrogen metabolic process IDA
IDA: Inferred from direct assay
16221673 GOA
involved in ethanol catabolic process IDA
IDA: Inferred from direct assay
23207770 GOA
involved in flavonoid metabolic process IDA
IDA: Inferred from direct assay
20056724 GOA
acts upstream of or within sulfation IDA
IDA: Inferred from direct assay
19548878 GOA
involved in sulfation IDA
IDA: Inferred from direct assay
20056724 GOA
involved in xenobiotic metabolic process IDA
IDA: Inferred from direct assay
12471039 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SULT1A1 Protein Structure

Sulfotransfer_1

Sulfotransfer_1: Sulfotransferase domain (38 - 287)

  • 0
  • 100
  • 200
  • 295 a.a.
Protein Preferred Names Protein Names

sulfotransferase 1A1

aryl sulfotransferase 1

Recombinant SULT1A1 Proteins

Cat. No. Product Name Accession Purity
HY-P70969 SULT1A1 Protein, Human (His) AAH00923.1 (M1-L295) ≥95%

Related Diseases

Diseases Alias
Mandibulofacial Dysostosis With Alopecia

MFDA
Acetaminophen Metabolism
Ceroid Lipofuscinosis, Neuronal, 3

Batten Disease

Juvenile Neuronal Ceroid Lipofuscinosis

Neuronal Ceroid Lipofuscinosis 3

CLN3

Jncl

Spielmeyer-Vogt Disease

Vogt-Spielmeyer Disease

Spielmeyer-Sjogren Disease

Cln3 Disease

Neuronal Ceroid Lipofuscinosis, Juvenile

Cln3 Disease, Juvenile

Spielmeyer Sjogren Disease

Vogt Spielmeyer Disease

Batten-Mayou Disease

Batten-Spielmeyer-Vogt Disease

Cln3-Related Neuronal Ceroid-Lipofuscinosis

Juvenile Batten Disease

Juvenile Cerebroretinal Degeneration

Classic Juvenile Ncl

Classic Juvenile Neuronal Ceroid Lipofuscinosis

Juvenile Ncl

Lipofuscinosis, Ceroid, Neuronal, Type 3
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14013 SULT1A1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS14016 SULT1B1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS14019 SULT1E1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SULT1A1 RGD RGD:3767
Mus musculus SULT1A1 MGD MGI:102896
Others SULT1A1 NCBI