Rtn4 - reticulon 4 Gene

Mus musculus

Also known as ASY; NgA; NOGO; NSP-CL; Nogo-A; Nogo-B; Nogo-C; mKIAA0886; mKIAA4153; 1110020G17Rik; C130026I10Rik

Gene ID: 68585 | Gene type: protein coding

About Rtn4

Summary

Predicted to enable cadherin binding activity; protein homodimerization activity; and ubiquitin protein Ligase binding activity. Involved in several processes, including neurogenesis; positive regulation of leukocyte migration; and vasculogenesis. Acts upstream of or within blastocyst formation; circulatory system development; and regulation of cell growth. Located in several cellular components, including dendritic growth cone; neuronal cell body; and postsynaptic density. Is expressed in several structures, including central nervous system; genitourinary system; limb mesenchyme; sensory organ; and skeletal musculature. Orthologous to human RTN4 (reticulon 4). [provided by Alliance of Genome Resources, Apr 2022]

Rtn4 Products(5)

mRNA	Protein	Name
NM_024226.4	NP_077188.1	reticulon-4 isoform C
NM_194051.3	NP_918940.1	reticulon-4 isoform D
NM_194052.3	NP_918941.1	reticulon-4 isoform B1
NM_194053.3	NP_918942.1	reticulon-4 isoform B2
NM_194054.3	NP_918943.1	reticulon-4 isoform A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11201742	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in axonal fasciculation	IMP IMP: Inferred from mutant phenotype	20573699	MGI
acts upstream of or within blastocyst formation	IMP IMP: Inferred from mutant phenotype	27869233	MGI
acts upstream of or within cardiac epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	19156209	MGI
involved in cell migration involved in vasculogenesis	IMP IMP: Inferred from mutant phenotype	23625008	MGI
involved in cellular response to hypoxia	IDA IDA: Inferred from direct assay	27763637	MGI
involved in central nervous system vasculogenesis	IMP IMP: Inferred from mutant phenotype	23625008	MGI
involved in cerebral cortex radial glia-guided migration	IMP IMP: Inferred from mutant phenotype	20093372	MGI
involved in intracellular sphingolipid homeostasis	IMP IMP: Inferred from mutant phenotype	26301690	MGI
involved in leukocyte migration involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	21183689	MGI
involved in modulation of chemical synaptic transmission	EXP EXP: Inferred from Experiment	30040841	MGI
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	30040841	MGI
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	30040841	MGI
involved in negative regulation of axon extension	IMP IMP: Inferred from mutant phenotype	20573699	MGI
involved in negative regulation of vasculogenesis	IMP IMP: Inferred from mutant phenotype	23625008	MGI
acts upstream of or within nervous system development	IDA IDA: Inferred from direct assay	12225863	MGI
involved in positive regulation of Rac protein signal transduction	IMP IMP: Inferred from mutant phenotype	19805174	MGI
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	19805174	MGI
involved in positive regulation of artery morphogenesis	IMP IMP: Inferred from mutant phenotype	19805174	MGI
involved in positive regulation of hepatocyte proliferation	IMP IMP: Inferred from mutant phenotype	23299899	MGI
involved in positive regulation of macrophage cytokine production	IMP IMP: Inferred from mutant phenotype	19805174	MGI
involved in positive regulation of macrophage migration	IMP IMP: Inferred from mutant phenotype	19805174	MGI
involved in positive regulation of neutrophil migration	IMP IMP: Inferred from mutant phenotype	21183689	MGI
involved in positive regulation of toll-like receptor 9 signaling pathway	IMP IMP: Inferred from mutant phenotype	25917084	MGI
involved in protein localization to lysosome	IMP IMP: Inferred from mutant phenotype	25917084	MGI
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	27353365	MGI
involved in regulation of branching morphogenesis of a nerve	IMP IMP: Inferred from mutant phenotype	20573699	MGI
involved in regulation of nervous system development	IMP IMP: Inferred from mutant phenotype	20573699	MGI
involved in regulation of postsynapse assembly	EXP EXP: Inferred from Experiment	26748478	MGI
involved in regulation of postsynapse assembly	IDA IDA: Inferred from direct assay	26748478	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell projection	IDA IDA: Inferred from direct assay	15121177	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	12225863	MGI
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	26301690	MGI
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	26748478	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	26748478	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	30040841	MGI
is active in postsynapse	IDA IDA: Inferred from direct assay	30040841	MGI
is active in postsynapse	IMP IMP: Inferred from mutant phenotype	30040841	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	17114649	MGI
located in synapse	IDA IDA: Inferred from direct assay	35771867	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

reticulon-4

neurite outgrowth inhibitor

Rtn4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Rtn4	Q99P72	Hspa4l	Mus musculus	P48722	Anti Bait CoIP	23909438
Intra	Rtn4	Q99P72	Hspa4l	Mus musculus	P48722	PLA	23909438
Intra	Rtn4	Q99P72	Hspa4l	Mus musculus	P48722	Confocal	23909438

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12332	RTN4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12333	RTN4IP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12334	RTN4R Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12335	RTN4RL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rtn4	NCBI	NCBI:57142
Macaca fascicularis	Rtn4	NCBI	NCBI:101865007

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