TAF11 - TATA-box binding protein associated factor 11 Gene

Homo sapiens

Also known as TAF2I; PRO2134; TAFII28; MGC:15243

Gene ID: 6882 | Gene type: protein coding

About TAF11

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:34,877,462-34,888,071 (from NCBI)

This gene has 12 transcripts (splice variants), 208 orthologues and 14 paralogues. Ubiquitous expression in testis (RPKM 12.6), bone marrow (RPKM 9.8) and 25 other tissues.

Summary

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit of TFIID that is present in all TFIID complexes and interacts with TBP. This subunit also interacts with another small subunit, TAF13, to form a heterodimer with a structure similar to the histone core structure. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]

TAF11 Products(2)

mRNA	Protein	Name
NM_001270488.1	NP_001257417.1	transcription initiation factor TFIID subunit 11 isoform 2
NM_005643.4	NP_005634.1	transcription initiation factor TFIID subunit 11 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables TBP-class protein binding	IPI IPI: Inferred from physical interaction	29111974	GOA
enables nuclear thyroid hormone receptor binding	IPI IPI: Inferred from physical interaction	10744685	GOA
enables nuclear vitamin D receptor binding	IPI IPI: Inferred from physical interaction	10744685	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7729427	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	8670810	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in RNA polymerase II preinitiation complex assembly	IPI IPI: Inferred from physical interaction	27007846	GOA
involved in mRNA transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17884155	GOA
involved in positive regulation by host of viral transcription	IDA IDA: Inferred from direct assay	9108034	GOA
involved in positive regulation of transcription initiation by RNA polymerase II	IDA IDA: Inferred from direct assay	17884155	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	EXP EXP: Inferred from Experiment	23332750	GOA
part of transcription factor TFIID complex	IDA IDA: Inferred from direct assay	7729427	GOA
part of transcription factor TFIID complex	IPI IPI: Inferred from physical interaction	23332750	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAF11 Protein Structure

TAFII28

0
100
211 a.a.

Protein Preferred Names

Protein Names

transcription initiation factor TFIID subunit 11

TAF(II)28

Related Diseases

Diseases

Alias

Facioscapulohumeral Muscular Dystrophy 1

Facioscapulohumeral Muscular Dystrophy	Fshd
Landouzy-Dejerine Muscular Dystrophy	Muscular Dystrophy, Facioscapulohumeral
FSHD1	Fshd1a
Muscular Dystrophy, Facioscapulohumeral, Type 1a	Facioscapulohumeral Muscular Dystrophy Type 1a
Fsh Muscular Dystrophy	Facioscapulohumeral Muscular Dystrophy 1a
Facioscapulohumeral Atrophy	Facioscapulohumeral Myopathy
Muscular Dystrophy, Facioscapulohumeral, Type 1	Facioscapulohumeral Muscular Dystrophy Type 1
Landouzy Dejerine Muscular Dystrophy	Muscular Dystrophy, Landouzy-Dejerine
Fshmd1a	Facio-Scapulo-Humeral Dystrophy
Facioscapulohumeral Type Progressive Muscular Dystrophy	Facioscapuloperoneal Muscular Dystrophy
Facioscapulohumeral Dystrophy	Fsh Dystrophy
Landouzy-Dejerine Dystrophy	Landouzy-Dejerine Myopathy
Fmd	Facioscapulohumeral Muscular Dystrophy-1a
Muscular Dystrophy Facioscapulohumeral	Dystrophy, Muscular, Facioscapulohumeral
Dystrophy, Muscular, Facioscapulohumeral, Type 1	Landouzy-Dejerine Disease
Landouzy-Déjerine Atrophy	Facioscapulohumeral Muscle Dystrophy
Fmd - [Facioscapulohumeral Muscular Dystrophy]	Fsh - [Facioscapulohumeral Muscular Dystrophy]
Fshd - [Facioscapulohumeral Muscular Dystrophy]	Landouzy-Déjerine Dystrophy Or Facioscapulohumeral Atrophy
Landouzy-Déjérine Muscular Dystrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14159	TAF11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TAF11	VGNC	VGNC:54240
Macaca mulatta	TAF11	VGNC	VGNC:83477
Felis catus	TAF11	VGNC	VGNC:102529
Mus musculus	TAF11	MGD	MGI:1916026
Rattus norvegicus	TAF11	RGD	RGD:1305626
Canis familiaris	TAF11	VGNC	VGNC:47074

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