2. Gene
  3. TAPBP - TAP binding protein Gene

TAPBP - TAP binding protein Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TPN; TAPA; TPSN; NGS17

Gene ID: 6892 | Gene type: protein coding

About TAPBP

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:33,299,694-33,314,078 (from NCBI)

This gene has 26 transcripts (splice variants), 1 gene allele, 210 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in spleen (RPKM 38.1), appendix (RPKM 25.3) and 25 other tissues.

Summary

This gene encodes a Transmembrane Glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic Peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

TAPBP Products(4)

mRNA Protein Name
NM_001410875.1 NP_001397804.1 tapasin isoform 4 precursor
NM_003190.5 NP_003181.3 tapasin isoform 1 precursor
NM_172208.3 NP_757345.2 tapasin isoform 2 precursor
NM_172209.3 NP_757346.2 tapasin isoform 3 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables TAP complex binding IDA
IDA: Inferred from direct assay
17947644 GOA
enables TAP1 binding IDA
IDA: Inferred from direct assay
22638925 GOA
enables TAP1 binding IPI
IPI: Inferred from physical interaction
12047747 GOA
enables TAP2 binding IDA
IDA: Inferred from direct assay
22638925 GOA
enables TAP2 binding IPI
IPI: Inferred from physical interaction
12047747 GOA
enables molecular adaptor activity IDA
IDA: Inferred from direct assay
17947644 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12213826 GOA
enables protein folding chaperone IDA
IDA: Inferred from direct assay
36104323 GOA
Biological Process GO Annotation Evidence Reference Source
involved in MHC class Ib protein complex assembly IMP
IMP: Inferred from mutant phenotype
12582157 GOA
involved in peptide antigen assembly with MHC class I protein complex IDA
IDA: Inferred from direct assay
10636848 GOA
involved in protein-containing complex assembly IDA
IDA: Inferred from direct assay
17947644 GOA
involved in regulation of gene expression IMP
IMP: Inferred from mutant phenotype
18802093 GOA
involved in regulation of protein complex stability IDA
IDA: Inferred from direct assay
18802093 GOA
Cellular Component GO Annotation Evidence Reference Source
located in Golgi membrane IDA
IDA: Inferred from direct assay
11884415 GOA
part of MHC class I peptide loading complex IDA
IDA: Inferred from direct assay
17947644 GOA
part of Tapasin-ERp57 complex IPI
IPI: Inferred from physical interaction
19119025 GOA
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
11884415 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAPBP Protein Structure

C1-set

C1-set: Immunoglobulin C1-set domain (308 - 391)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 504 a.a.
Protein Preferred Names Protein Names

tapasin

NGS-17

TAPBP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TAPBP O15533 HLA-A Homo sapiens P01892
Anti Bait CoIP
24163410
Intra
TAPBP O15533 HLA-A Homo sapiens P01892
Anti Tag CoIP
24163410
Intra
TAPBP O15533 TAP1 Homo sapiens Q03518
Anti Bait CoIP
12213826
Intra
TAPBP O15533 TAP1 Homo sapiens Q03518
Anti Bait CoIP
17055437
Intra
TAPBP O15533 TAP1 Homo sapiens Q03518
Anti Bait CoIP
19201886
Intra
TAPBP O15533 TAP2 Homo sapiens Q03519
Anti Bait CoIP
19201886
Intra
TAPBP O15533 TAP2 Homo sapiens Q03519
Anti Bait CoIP
12213826
Cross
TAPBP O15533 bnl2a_ebvb9 Epstein-Barr virus P0C739
Anti Bait CoIP
19201886
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TAPBP Proteins

Cat. No. Product Name Accession Purity
HY-P73619 Tapasin Protein, Human (HEK293, His) O15533 (G21-V414) ≥95%

Related Diseases

Diseases Alias
Bare Lymphocyte Syndrome, Type I

Hla Class I Deficiency

Mhc Class I Deficiency

Bls, Type I

Bare Lymphocyte Syndrome Type I

Bare Lymphocyte Syndrome, Type I, Due To Tap2 Deficiency

Blsi

Mhc Class 1 Deficiency

Major Histocompatibility Complex Class 1 Deficiency

Bare Lymphocyte Syndrome 1

BLS1

Bls I

Bls Type I

Bl-1

Bare Lymphocyte Syndrome Type 1

Immunodeficiency By Defective Expression Of Hla - [Human Leukocyte Antigen] Class 1

Scid - [Severe Combined Immunodeficiency] Due To Absent Class 2 Hla Antigens

Bls - [Bare Lymphocyte Syndrome] Nos
Immunodeficiency By Defective Expression Of Mhc Class I

Bare Lymphocyte Syndrome Type 1

Mhc Class I Deficiency
Spondyloarthropathy 1

Ankylosing Spondylitis

Spondyloarthropathy, Susceptibility To, 1

SPDA1

Marie-Strumpell Spondylitis

Bechterew Syndrome

Spa

Spondylarthritis Ankylopoietica

Reiter Syndrome

Ankylosing Spondylitis, Susceptibility To

Bekhterev Syndrome

Bekhterev'S Disease

Marie-Strumpell Disease

Axial Spondylarthritis

Bechterew Disease

Marie-Struempell Disease

Spondylitis Ankylopoietica

Spondyloarthritis

Spondyloarthritis Ankylopoietica

Spas

Ankylosing Spondylarthritis

Psoriatic Arthritis

Reactive Arthritis

Rheumatoid Spondylitis

Spondylitis Ankylosans

Spondylitis Ankylosing

Spondylitis, Ankylosing

Spondylarthropathies

Arthritis, Psoriatic

Arthritis, Reactive
Severe Combined Immunodeficiency

Scid

Severe Combined Immunodeficiency Disease

Combined T And B Cell Inborn Immunodeficiency

Immunodeficiency, Severe Combined

Scid - [Severe Combined Immunodeficiencies]
Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency

Congenital Combined Immunodeficiency

Syndrome With Combined Immunodeficiency

Combined T And B Cell Immunodeficiency

Combined Immunity Deficiency

Combined Immunodeficiency Syndrome

Combined T-Cell And B-Cell Immunodeficiency

Lymphopenic Agammaglobulinaemia
Malaria

Malaria, Susceptibility To

Malaria, Resistance To

Malaria, Cerebral

Cerebral Malaria

Malaria, Severe, Susceptibility To

Malaria, Severe, Resistance To

Malaria, Cerebral, Susceptibility To

Induced Malaria

Malaria, Vivax, Protection Against

Malaria, Severe

Malaria, Cerebral, Reduced Risk Of

Malaria, Protection Against

Resistance To Malaria Due To G6pd Deficiency

Malaria Due To G6pd Deficiency

Malarial Encephalitis

CM

Malaria Cerebral

Susceptibility To Malaria

Acute Pernicious Fever

Aestivo-Autumnal Fever

Aestivo Autumnal Malaria

Chagres Fever

Continued Malaria Fever

Estivo-Autumnal Fever

Estivo-Autumnal Malaria

Estivo-Autumnal Malarial Fever

Falciparum Fever

Malignant Tertian Fever

Malignant Tertian Malaria

Pernicious Intermittent Fever

Pernicious Malaria

Quotidian Malaria

Subtertian Fever

Subtertian Malaria Fever

Subtertian Malignant Tertian Malaria

Tropical Malaria

Algid Malaria

Bilious Haemoglobinuric Fever

Black Water Fever

Blackwater Fever

Malarial Blackwater Fever

Severe Malarial Falciparum

West African Fever

Malarial Haematinuria

Haemoglobinuric Fever

Haemoglobinuric Malaria

Severe Plasmodium Falciparum Malaria

Malarial Haemoglobinuria

Malarial Haematuria

Falciparum Malaria [Malignant Tertian]

Malaria Tropica

Malarial Shock

Chagres Virus Disease

Malignant Malaria

Mtm - [Malignant Tertian Malaria]

Tm -[Malignant Tertian Malaria]

Panama Fever

St - [Subtertian Malaria]

Malarial Quotidian

Benign Tertian Malaria

Tertian Ague

Vivax Fever

Plasmodium Vivax Malaria Nos

Btm - [Benign Tertian Malaria]

Bt - [Benign Tertian Malaria]

Vivax Malaria

Benign Tertian Vivax Malaria

Tertian Malaria

Quartan Malaria

Quartan Ague

Quartan Fever

Plasmodium Malariae Malaria Nos

Quartan Malarial

Malaria By Plasmodium Malariae

Malariae Malaria

Ovale Tertian Malaria

Plasmodium Ovale Fever

Malaria Fever By Plasmodium Ovale

Ovale Malaria

Malaria By Plasmodium Ovale

Malarial Ovale

Marsh Fever

Remittent Congestive Fever

Coastal Fever

Remittent Gastric Fever

Miasmatic Fever

Congestive Remittent Fever

Intermittent Fever

Jungle Fever

Paludism

Cameroon Fever

Ague

Corsican Fever

Intermittent Bilious Fever

Disease Due To Plasmodiidae

Malarial Fever

Plasmodiosis

Remittent Fever

Roman Fever

Malaria Fever Nos

Malaria Nos

Paludal Fever

Clinically Diagnosed Malaria

Clinically Diagnosed Malaria Without Parasitological Confirmation

Congestive Fever

Malarial Cachexia

Marsh Cachexia

Paludal Cachexia

Recurrent Malaria

Remittent Malaria
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14203 TAPBP Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TAPBP MGD MGI:1201689
Bos taurus TAPBP VGNC VGNC:35599
Macaca mulatta TAPBP VGNC VGNC:78098
Rattus norvegicus TAPBP RGD RGD:3819
Canis familiaris TAPBP VGNC VGNC:47106
Others TAPBP NCBI