2. Gene
  3. TAP1 - transporter 1, ATP binding cassette subfamily B member Gene

TAP1 - transporter 1, ATP binding cassette subfamily B member Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as APT1; PSF1; ABC17; ABCB2; PSF-1; RING4; TAP1N; D6S114E; TAP1*0102N

Gene ID: 6890 | Gene type: protein coding

About TAP1

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:32,845,209-32,853,704 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele, 217 orthologues, 10 paralogues and is associated with 3 phenotypes. Ubiquitous expression in spleen (RPKM 57.6), appendix (RPKM 54.1) and 24 other tissues.

Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic Peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

TAP1 Products(2)

mRNA Protein Name
NM_000593.6 NP_000584.3 antigen peptide transporter 1 isoform 1
NM_001292022.2 NP_001278951.1 antigen peptide transporter 1 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ABC-type peptide antigen transporter activity IDA
IDA: Inferred from direct assay
11133832 GOA
enables ABC-type peptide antigen transporter activity IMP
IMP: Inferred from mutant phenotype
25656091 GOA
enables ADP binding IDA
IDA: Inferred from direct assay
11532960 GOA
enables ATP binding IDA
IDA: Inferred from direct assay
7673167 GOA
enables ATP binding IMP
IMP: Inferred from mutant phenotype
15793001 GOA
enables MHC class Ib protein binding IPI
IPI: Inferred from physical interaction
10605026 GOA
enables TAP2 binding IPI
IPI: Inferred from physical interaction
1538751 GOA
enables peptide antigen binding IDA
IDA: Inferred from direct assay
7500034 GOA
contributes to peptide transmembrane transporter activity IGI
IGI: Inferred from genetic interaction
7673167 GOA
enables peptide transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
17418234 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12213826 GOA
Biological Process GO Annotation Evidence Reference Source
involved in antigen processing and presentation of endogenous peptide antigen via MHC class I IDA
IDA: Inferred from direct assay
11133832 GOA
involved in antigen processing and presentation of endogenous peptide antigen via MHC class I IMP
IMP: Inferred from mutant phenotype
11133832 GOA
involved in cytosol to endoplasmic reticulum transport IMP
IMP: Inferred from mutant phenotype
7538543 GOA
involved in peptide transport IMP
IMP: Inferred from mutant phenotype
11133832 GOA
Cellular Component GO Annotation Evidence Reference Source
part of MHC class I peptide loading complex IDA
IDA: Inferred from direct assay
17947644 GOA
part of TAP complex IDA
IDA: Inferred from direct assay
11133832 GOA
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
7673167 GOA
located in membrane IDA
IDA: Inferred from direct assay
8955196 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAP1 Protein Structure

ABC_membrane

ABC_membrane: ABC transporter transmembrane region (249 - 518)

ABC_tran

ABC_tran: ABC transporter (581 - 731)

  • 0
  • 200
  • 400
  • 600
  • 808 a.a.
Protein Preferred Names Protein Names

antigen peptide transporter 1

ABC transporter, MHC 1

TAP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TAP1 Q03518 CALR Homo sapiens P27797
Anti Bait CoIP
17055437
Intra
TAP1 Q03518 LCE2C Homo sapiens Q5TA81
Validated Y2H
32296183
Intra
TAP1 Q03518 LCE2C Homo sapiens Q5TA81
Y2H Array
32296183
Intra
TAP1 Q03518 LCE2C Homo sapiens Q5TA81
Y2H Prey Pooling
32296183
Intra
TAP1 Q03518 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
Intra
TAP1 Q03518 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
TAP1 Q03518 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
TAP1 Q03518 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra
TAP1 Q03518 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
Intra
TAP1 Q03518 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra
TAP1 Q03518 SSMEM1 Homo sapiens Q8WWF3
Validated Y2H
32296183
Intra
TAP1 Q03518 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
Intra
TAP1 Q03518 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
Intra
TAP1 Q03518 SLC35C2 Homo sapiens Q9NQQ7-3
Validated Y2H
32296183
Intra
TAP1 Q03518 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Array
32296183
Intra
TAP1 Q03518 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Prey Pooling
32296183
Intra
TAP1 Q03518 ERVFRD-1 Homo sapiens P60508
Y2H Array
32296183
Intra
TAP1 Q03518 ERVFRD-1 Homo sapiens P60508
Y2H Prey Pooling
32296183
Intra
TAP1 Q03518 SLC10A6 Homo sapiens Q3KNW5
Validated Y2H
32296183
Intra
TAP1 Q03518 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra
TAP1 Q03518 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra
TAP1 Q03518 RNF19B Homo sapiens Q6ZMZ0
Y2H Prey Pooling
32296183
Intra
TAP1 Q03518 RNF19B Homo sapiens Q6ZMZ0
Validated Y2H
32296183
Intra
TAP1 Q03518 RNF19B Homo sapiens Q6ZMZ0
Y2H Array
32296183
Intra
TAP1 Q03518 GEMIN4 Homo sapiens P57678
Y2H Array
32296183
Intra
TAP1 Q03518 GEMIN4 Homo sapiens P57678
Y2H Prey Pooling
32296183
Intra
TAP1 Q03518 SLC10A1 Homo sapiens Q14973
Validated Y2H
32296183
Intra
TAP1 Q03518 SLC10A1 Homo sapiens Q14973
Y2H Array
32296183
Intra
TAP1 Q03518 SLC10A1 Homo sapiens Q14973
Y2H Prey Pooling
32296183
Intra
TAP1 Q03518 P4HB Homo sapiens P07237
Anti Bait CoIP
17055437
Intra
TAP1 Q03518 THOC5 Homo sapiens Q13769
Y2H
19165146
Intra
TAP1 Q03518 THOC5 Homo sapiens Q13769
Pull Down
19165146
Intra
TAP1 Q03518 TAP2 Homo sapiens Q03519
Anti Bait CoIP
19201886
Intra
TAP1 Q03518 TAP2 Homo sapiens Q03519
Crosslink
19297616
Intra
TAP1 Q03518 TAP2 Homo sapiens Q03519
Anti Bait CoIP
17055437
Intra
TAP1 Q03518 TAP2 Homo sapiens Q03519
Anti Tag CoIP
18802093
Intra
TAP1 Q03518 TAP2 Homo sapiens Q03519
Pull Down
26789246
Intra
TAP1 Q03518 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
TAP1 Q03518 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
TAP1 Q03518 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
TAP1 Q03518 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra
TAP1 Q03518 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra
TAP1 Q03518 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra
TAP1 Q03518 TAPBP Homo sapiens O15533
Anti Tag CoIP
18802093
Intra
TAP1 Q03518 TAPBP Homo sapiens O15533
Anti Bait CoIP
19201886
Intra
TAP1 Q03518 TAPBP Homo sapiens O15533
Anti Bait CoIP
17055437
Intra
TAP1 Q03518 PDIA3 Homo sapiens P30101
Anti Bait CoIP
17055437
Intra
TAP1 Q03518 PDIA3 Homo sapiens P30101
Pull Down
30833792
Cross
TAP1 Q03518 gN Bovine herpesvirus 1.1 Q77CE4
Anti Bait CoIP
18802093
Cross
TAP1 Q03518 gN Bovine herpesvirus 1.1 Q77CE4
Anti Tag CoIP
18802093
Cross
TAP1 Q03518 bnl2a_ebvb9 Epstein-Barr virus P0C739
Anti Bait CoIP
19201886
Cross
TAP1 Q03518 bnl2a_ebvb9 Epstein-Barr virus P0C739
IF
19201886
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Bare Lymphocyte Syndrome, Type I

Hla Class I Deficiency

Mhc Class I Deficiency

Bls, Type I

Bare Lymphocyte Syndrome Type I

Bare Lymphocyte Syndrome, Type I, Due To Tap2 Deficiency

Blsi

Mhc Class 1 Deficiency

Major Histocompatibility Complex Class 1 Deficiency

Bare Lymphocyte Syndrome 1

BLS1

Bls I

Bls Type I

Bl-1

Bare Lymphocyte Syndrome Type 1

Immunodeficiency By Defective Expression Of Hla - [Human Leukocyte Antigen] Class 1

Scid - [Severe Combined Immunodeficiency] Due To Absent Class 2 Hla Antigens

Bls - [Bare Lymphocyte Syndrome] Nos
Immunodeficiency By Defective Expression Of Mhc Class I

Bare Lymphocyte Syndrome Type 1

Mhc Class I Deficiency
Spondylitis
Herpes Simplex

Herpes Simplex Infections

Herpesvirus Hominis Disease

Herpes Simplex Disease

Herpesviral Infection Due To Herpes Simplex

Infections Due To Simplex Virus

Herpes Nos
Type 1 Diabetes Mellitus

Diabetes Mellitus, Insulin-Dependent

Diabetes Mellitus Type 1

IDDM

Type 1 Diabetes

Insulin-Dependent Diabetes Mellitus

T1D

Juvenile-Onset Diabetes

Jod

Diabetes Mellitus, Type 1

Diabetes Mellitus, Insulin-Dependent-1

Type I Diabetes Mellitus

Autoimmune Diabetes

Juvenile Diabetes

Juvenile-Onset Diabetes Mellitus

Diabetes, Insulin Dependent

Insulin-Dependent Diabetes Mellitus-1

Diabetes Mellitus Insulin-Dependent

Diabetes Autoimmune

Diabetes Mellitus, Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 1, Susceptibility To

Diabetes Type 1

Type I Diabetes

Diabetes, Autoimmune

T1dm - [Type 1 Diabetes Mellitus]

Iddm - [Insulin Dependent Diabetes Mellitus]

Type 1 Iddm

Juvenile Diabetes Mellitus Without Compications

Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications

Juvenile-Onset Diabetes Mellitus Without Compications

Ketosis-Prone Diabetes Mellitus Without Compications

Juvenile-Onset-Type Diabetes Mellitus Without Compications
Diabetes Mellitus

Diabetes
Suppressor Of Tumorigenicity 3

Cervical Carcinoma

ST3

Tumor-Suppressor Gene, Hela Cell Type

Tshl

Cervical Carcinoma, Tumor-Suppressor Gene Involved In

Ccts

Cervix Carcinoma
Autoimmune Disease

Autoimmune Diseases

Autoimmune Hypersensitivity Disease

Hypersensitivity Reaction Type Ii Disease

Type Ii Hypersensitivity Reaction Disease
Cervical Cancer

Cervical Cancer, Somatic

Neoplasm Of Uterine Cervix

Cervix Cancer

Uterine Cervical Neoplasm

Cervical Neoplasm

Cervix Uteri Cancer

Tumor Of The Cervix Uteri

CERCA

Uterine Cervical Cancer

Neoplasms Cervical

Uterine Cervical Neoplasms

Cervical Cancers

Cancer, Cervical, Somatic

Malignant Tumor Of Cervix

Cervix Carcinoma
Severe Combined Immunodeficiency

Scid

Severe Combined Immunodeficiency Disease

Combined T And B Cell Inborn Immunodeficiency

Immunodeficiency, Severe Combined

Scid - [Severe Combined Immunodeficiencies]
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis
Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P5865 Tap1a Inhibitor / Unkown
HY-RS14201 TAP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TAP1 VGNC VGNC:35598
Mus musculus TAP1 MGD MGI:98483
Rattus norvegicus TAP1 RGD RGD:3817
Canis familiaris TAP1 VGNC VGNC:47105
Others TAP1 NCBI