TBCA - tubulin folding cofactor A Gene

Homo sapiens

Gene ID: 6902 | Gene type: protein coding

About TBCA

Cytogenetic location: 5q14.1 Genomic coordinates (GRCh38): 5:77,691,166-77,776,339 (from NCBI)

This gene has 10 transcripts (splice variants) and 212 orthologues. Ubiquitous expression in adrenal (RPKM 23.9), kidney (RPKM 17.1) and 25 other tissues.

Summary

The product of this gene is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. This gene encodes chaperonin cofactor A. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

TBCA Products(3)

mRNA	Protein	Name
NM_001297738.2	NP_001284667.1	tubulin-specific chaperone A isoform 1
NM_001297740.2	NP_001284669.1	tubulin-specific chaperone A isoform 3
NM_004607.3	NP_004598.1	tubulin-specific chaperone A isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TBCA Protein Structure

TBCA

0
100
108 a.a.

Protein Preferred Names

Protein Names

tubulin-specific chaperone A

CFA

TBCA Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	TBCA	O75347	P0DTC1-PRO_0000449645	SARS-CoV-2	P0DTC1-PRO_0000449645	Pull Down	33060197
Intra	TBCA	O75347	TERF2IP	Homo sapiens	Q9NYB0	Pull Down	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TBCA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73565	Tubulin cofactor A Protein, Human	O75347 (M1-A108)	≥95%
HY-P73565A	Tubulin cofactor A Protein, Human (Tag Free)	O75347 (M1-A108)	≥95%

Related Diseases

Diseases

Alias

Hypoparathyroidism-Retardation-Dysmorphism Syndrome

Sanjad-Sakati Syndrome	Hrd Syndrome
HRDS	Hypoparathyroidism-Intellectual Disability-Dysmorphism Syndrome
Hypoparathyroidism-Short Stature-Intellectual Disability-Seizures Syndrome	Richardson-Kirk Syndrome
Sss	Hypoparathyroidism With Short Stature, Mental Retardation, And Seizures
Hypoparathyroidism, Congenital, Associated With Dysmorphism, Growth Retardation, And Developmental Delay	Hypoparathyroidism With Short Stature, Mental Retardation And Seizures
Hypoparathyroidism With Short Stature, Intellectual Disability And Seizures	Hypoparathyroidism, Congenital, Associated With Dysmorphism, Growth Retardation And Developmental Delay

Juvenile Ankylosing Spondylitis

Kenny-Caffey Syndrome

Kenny Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-110052	TBCA	Inhibitor	99.45%	Unkown
HY-RS14250	TBCA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TBCA	VGNC	VGNC:78104
Bos taurus	TBCA	VGNC	VGNC:35648
Rattus norvegicus	TBCA	RGD	RGD:1311538
Canis familiaris	TBCA	VGNC	VGNC:53246
Mus musculus	TBCA	MGD	MGI:107549
Felis catus	TBCA	VGNC	VGNC:102340
Others	TBCA	NCBI

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