TCF21 - transcription factor 21 Gene

Homo sapiens

Also known as POD1; bHLHa23

Gene ID: 6943 | Gene type: protein coding

About TCF21

Cytogenetic location: 6q23.2 Genomic coordinates (GRCh38): 6:133,889,113-133,895,537 (from NCBI)

This gene has 2 transcripts (splice variants), 218 orthologues and 13 paralogues. Broad expression in placenta (RPKM 32.6), spleen (RPKM 25.0) and 15 other tissues.

Summary

TCF21 encodes a transcription factor of the basic helix-loop-helix family. The TCF21 product is mesoderm specific, and expressed in embryonic epicardium, mesenchyme-derived tissues of lung, gut, gonad, and both mesenchymal and glomerular epithelial cells in the kidney. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

TCF21 Products(2)

mRNA	Protein	Name
NM_003206.4	NP_003197.2	transcription factor 21
NM_198392.3	NP_938206.1	transcription factor 21

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12493738	GOA
enables bHLH transcription factor binding	IPI IPI: Inferred from physical interaction	12493738	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12493738	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	12493738	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TCF21 Protein Structure

HLH

0
100
179 a.a.

Protein Preferred Names

Protein Names

transcription factor 21

capsulin

Related Diseases

Diseases

Alias

Paralytic Ileus

Adynamic Ileus	Paralytic Ileus Of Bowel
Ileus Nos	Paralysis Of Bowel
Paralysis Of Intestine	Adynamic Intestinal Obstruction
Paralytic Intestinal Ileus

Pain Agnosia

Analgesia

Subacute Lymphocytic Thyroiditis

Pericoronitis

Operculitis

Agnosia

Dyspraxia	Primary Visual Agnosia
Dyspraxia Syndrome	Monomodal Visual Amnesia
Visual Amnesia	Agnosia, Primary Visual
Apraxias	Alexia

Peroneal Nerve Paralysis

Peroneal Nerve Palsy

Mediastinitis

Femoral Cancer

Femoral Neoplasms	Cancer Of The Femur
Femoral Neoplasm	Neoplasm Of Femur

Median Arcuate Ligament Syndrome

Celiac Artery Compression Syndrome	Dunbar Syndrome
Mals	Harjola-Marable Syndrome
Marable'S Syndrome	Celiac Axis Syndrome

Spondylolisthesis

Slipped Vertebrae

Acquired Spondylolisthesis

Intestinal Obstruction

Inspissated Milk Syndrome

Milk Curd Syndrome

Aspiration Pneumonia

Pneumonia, Aspiration	Pneumonia Aspiration
Aspiration Pneumonitis

Supine Hypotensive Syndrome

Maternal Hypotension Syndrome	Antepartum Maternal Hypotension Syndrome
Postpartum Maternal Hypotension Syndrome	Maternal Hypotension Syndrome, Antepartum Condition Or Complication
Maternal Hypotension Syndrome, Postpartum Condition Or Complication	Maternal Hypotension Syndrome, Unspecified Trimester

Inguinal Hernia

Hernia Inguinal	Hernia, Inguinal
Inguinal Hernias	Bubonocele
Indirect Inguinal Hernia	Direct Inguinal Hernia
Oblique Inguinal Hernia	Scrotal Hernia
Ih - [Inguinal Hernia]

Specific Developmental Disorder

Lipoprotein Quantitative Trait Locus

Coronary Artery Disease	Coronary Artery Anomaly
Coronary Artery Disease, Susceptibility To	Myocardial Ischemia
Congenital Anomaly Of Coronary Artery	Coronary Arteriosclerosis
Coronary Disease	Coronary Heart Disease
Coronary Artery Disorder	LPAQTL
Lpa Deficiency, Congenital	Coronary Artery Abnormality
Coronary Artery Anomaly, Congenital	Chd
Coronary Syndrome	Congenital Malformations Of Coronary Vessels
Malformation Of Coronary Vessels	Congenital Coronary Artery Anomaly
Congenital Coronary Artery Deformity	Congenital Coronary Artery Disorder
Abnormal Coronary Artery	Congenital Coronary Artery Malposition
Congenital Coronary Disease	Congenital Anomaly Of Coronary Arteries

Wilms Tumor 1

Nephroblastoma	Wilms Tumor
WT1	Wilms' Tumor
Bilateral Wilms Tumor	Wilms Tumor, Type 1
Wilms Tumor, Somatic	Adult Nephroblastoma
Wt1 Disorder	Renal Embryonic Tumor
Adult Kidney Wilms Tumor	Childhood Kidney Wilms Tumor
Nonanaplastic Kidney Wilms Tumor

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14303	TCF21 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TCF21	MGD	MGI:1202715
Canis familiaris	TCF21	VGNC	VGNC:47193
Macaca mulatta	TCF21	VGNC	VGNC:78286
Felis catus	TCF21	VGNC	VGNC:66024
Bos taurus	TCF21	VGNC	VGNC:35690
Rattus norvegicus	TCF21	RGD	RGD:620523

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