DYNLT3 - dynein light chain Tctex-type 3 Gene

Homo sapiens

Also known as RP3; TCTE1L; TCTEX1L

Gene ID: 6990 | Gene type: protein coding

About DYNLT3

Cytogenetic location: Xp11.4 Genomic coordinates (GRCh38): X:37,838,836-37,847,571 (from NCBI)

Summary

This gene encodes a member of a subclass of dynein light chains. The encoded protein homodimerizes and forms the light chain component of the cytoplasmic dynein motor protein complex. This protein may be important for binding dynein to specific cargos including the spindle checkpoint protein BUB3. This protein may also function independently of dynein as a transcriptional modulator. Pseudogenes of this gene are found on chromosomes 2 and 20.[provided by RefSeq, Mar 2010]

DYNLT3 Products(1)

mRNA	Protein	Name
NM_006520.3	NP_006511.1	dynein light chain Tctex-type 3

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of cytoplasmic dynein complex	IDA IDA: Inferred from direct assay	11425878	GOA
colocalizes with kinetochore	IDA IDA: Inferred from direct assay	17289665	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DYNLT3 Protein Structure

Tctex-1

0
100
116 a.a.

Protein Preferred Names

Protein Names

dynein light chain Tctex-type 3

protein 91/23

DYNLT3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DYNLT3	P51808	DYNLT1	Homo sapiens	P63172	Y2H Prey Pooling	32296183
Intra	DYNLT3	P51808	DYNLT1	Homo sapiens	P63172	Validated Y2H	32296183
Intra	DYNLT3	P51808	DYNLT1	Homo sapiens	P63172	Y2H Array	32296183
Intra	DYNLT3	P51808	DYNC1I2	Homo sapiens	Q13409-3	Validated Y2H	32296183
Intra	DYNLT3	P51808	ZC3H14	Homo sapiens	Q6PJT7-6	Y2H Prey Pooling	32296183
Intra	DYNLT3	P51808	ZC3H14	Homo sapiens	Q6PJT7-6	Y2H Array	32296183
Intra	DYNLT3	P51808	ZC3H14	Homo sapiens	Q6PJT7-6	Validated Y2H	32296183
Intra	DYNLT3	P51808	PMS1	Homo sapiens	P54277-2	Validated Y2H	32296183
Intra	DYNLT3	P51808	C2orf15	Homo sapiens	Q8WU43	Validated Y2H	32296183
Intra	DYNLT3	P51808	NIF3L1	Homo sapiens	Q9GZT8	Validated Y2H	25416956
Intra	DYNLT3	P51808	NIF3L1	Homo sapiens	Q9GZT8	Y2H Prey Pooling	25416956
Intra	DYNLT3	P51808	DYNLT3	Homo sapiens	P51808	Y2H Array	32296183
Intra	DYNLT3	P51808	CCL28	Homo sapiens	Q9NRJ3	Validated Y2H	32296183
Intra	DYNLT3	P51808	DYNLT3	Homo sapiens	P51808	Y2H Pooling	16189514
Intra	DYNLT3	P51808	DYNLT3	Homo sapiens	P51808	Validated Y2H	32296183
Intra	DYNLT3	P51808	DYNLT3	Homo sapiens	P51808	Y2H Prey Pooling	32296183
Intra	DYNLT3	P51808	DYNLT3	Homo sapiens	P51808	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Mcleod Syndrome

Mcleod Neuroacanthocytosis Syndrome	MLS
X-Linked Mcleod Syndrome	Mcleod Phenotype
Neuroacanthocytosis, Mcleod Type	Mcleod Syndrome With Or Without Chronic Granulomatous Disease
MCLDS	Mcleod Type Neuroacanthocytosis
Mcleod Syndrome With Chronic Granulomatous Disease	Neuroacanthocytosis Mcleod Type
Blood Group Deletion Syndrome

Bardet-Biedl Syndrome 7

BBS7	Bardet-Biedl Syndrome, Type 7

Neuroacanthocytosis

Neuroacanthocytosis Syndrome

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Asphyxiating Thoracic Dystrophy

Jeune Thoracic Dystrophy	Jeune Syndrome
Asphyxiating Thoracic Dysplasia	Short-Rib Thoracic Dysplasia With Or Without Polydactyly
Thoracic Pelvic Phalangeal Dystrophy	Asphyxiating Thoracic Chondrodystrophy
Atd	Chondroectodermal Dysplasia-Like Syndrome
Infantile Thoracic Dystrophy	Jeune Thoracic Dysplasia
Thoracic Asphyxiant Dystrophy	Thoracic-Pelvic-Phalangeal Dystrophy
Short-Rib Thoracic Dysplasia Without Polydactyly	Asphyxiating Thoracic Dystrophy Of The Newborn
Asphyxiating Thorax Dystrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04093	DYNLT3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DYNLT3	VGNC	VGNC:106439
Canis familiaris	DYNLT3	VGNC	VGNC:40154
Bos taurus	DYNLT3	VGNC	VGNC:28278
Rattus norvegicus	DYNLT3	RGD	RGD:1549755
Mus musculus	DYNLT3	MGD	MGI:1914367

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