DYNLT1 - dynein light chain Tctex-type 1 Gene

Homo sapiens

Also known as CW-1; TCTEL1; TCTEX1; tctex-1

Gene ID: 6993 | Gene type: protein coding

About DYNLT1

Cytogenetic location: 6q25.3 Genomic coordinates (GRCh38): 6:158,636,474-158,644,743 (from NCBI)

This gene has 3 transcripts (splice variants), 219 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 62.3), colon (RPKM 58.0) and 25 other tissues.

Summary

This gene encodes a component of the motor complex, cytoplasmic dynein, which transports cellular cargo along microtubules in the cell. The encoded protein regulates the length of primary cilia which are sensory organelles found on the surface of cells. The protein encoded by this gene interacts with Viral Proteins, like the minor capsid protein L2 of human papillomavirus, and is required for dynein-mediated delivery of the viral nucleic acid to the host nucleus. This protein interacts with oncogenic nucleoporins to disrupt gene regulation and cause leukemic transformation. Pseudogenes of this gene are present on chromosomes 4 and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]

DYNLT1 Products(3)

mRNA	Protein	Name
NM_001291602.2	NP_001278531.1	dynein light chain Tctex-type 1 isoform 2
NM_001291603.2	NP_001278532.1	dynein light chain Tctex-type 1 isoform 3
NM_006519.4	NP_006510.1	dynein light chain Tctex-type 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	17965411	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10644691	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in intracellular transport of viral protein in host cell	IMP IMP: Inferred from mutant phenotype	18647839	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of cytoplasmic dynein complex	IDA IDA: Inferred from direct assay	25205765	GOA
located in cytoplasmic microtubule	IDA IDA: Inferred from direct assay	21262767	GOA
part of dynein complex	IPI IPI: Inferred from physical interaction	24986880	GOA
located in secretory vesicle	IDA IDA: Inferred from direct assay	21262767	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DYNLT1 Protein Structure

Tctex-1

0
100
113 a.a.

Protein Preferred Names

Protein Names

dynein light chain Tctex-type 1

T-complex testis-specific protein 1 homolog

DYNLT1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DYNLT1	P63172	PELO	Homo sapiens	Q9BRX2	Validated Y2H	32296183
Intra	DYNLT1	P63172	HSPB9	Homo sapiens	Q9BQS6	Y2H	15503857
Intra	DYNLT1	P63172	HSPB9	Homo sapiens	Q9BQS6	Anti Bait CoIP	15503857
Intra	DYNLT1	P63172	TCEANC	Homo sapiens	Q8N8B7-2	Validated Y2H	32296183
Intra	DYNLT1	P63172	ARID4B	Homo sapiens	Q4LE39-3	Validated Y2H	32296183
Intra	DYNLT1	P63172	OLFM3	Homo sapiens	Q96PB7-3	Validated Y2H	32296183
Intra	DYNLT1	P63172	ACOX2	Homo sapiens	Q99424	Validated Y2H	32296183
Intra	DYNLT1	P63172	DYNC1I2	Homo sapiens	Q13409-3	Validated Y2H	32296183
Intra	DYNLT1	P63172	PITX2	Homo sapiens	Q99697-2	Validated Y2H	32296183
Intra	DYNLT1	P63172	DYNLT2B	Homo sapiens	Q8WW35	Validated Y2H	32296183
Intra	DYNLT1	P63172	DYNLT2B	Homo sapiens	Q8WW35	TAP	27173435
Intra	DYNLT1	P63172	CCDC68	Homo sapiens	Q9H2F9	Validated Y2H	32296183
Intra	DYNLT1	P63172	NHSL2	Homo sapiens	Q5HYW2	Validated Y2H	32296183
Intra	DYNLT1	P63172	UXT	Homo sapiens	Q9UBK9	Validated Y2H	32296183
Intra	DYNLT1	P63172	NEFL	Homo sapiens	P07196	Y2H Pooling	32814053
Intra	DYNLT1	P63172	NEFL	Homo sapiens	P07196	Validated Y2H	32814053
Intra	DYNLT1	P63172	NEFL	Homo sapiens	P07196	Y2H Array	32814053
Intra	DYNLT1	P63172	HSPB7	Homo sapiens	Q9UBY9	Validated Y2H	32296183
Intra	DYNLT1	P63172	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	DYNLT1	P63172	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	DYNLT1	P63172	DYNLT3	Homo sapiens	P51808	TAP	27173435
Intra	DYNLT1	P63172	RRAGA	Homo sapiens	Q7L523	Validated Y2H	32296183
Intra	DYNLT1	P63172	KLK15	Homo sapiens	Q9H2R5	Validated Y2H	32296183
Intra	DYNLT1	P63172	AARSD1	Homo sapiens	Q9BTE6-2	Validated Y2H	32296183
Intra	DYNLT1	P63172	MARK1	Homo sapiens	Q9P0L2	Validated Y2H	32296183
Cross	DYNLT1	P63172	gag	Mason-Pfizer monkey virus	P07567	Anti Bait CoIP	18647839

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Glaucomatocyclitic Crisis

Posner-Schlossman Syndrome

Terrien-Viel Syndrome

Pulmonary Hypertension

Primary Pulmonary Hypertension	Hypertension Pulmonary
Hypertension, Pulmonary	Hypertension, Pulmonary, Primary
Idiopathic Pulmonary Hypertension	Idiopathic Pulmonary Arterial Hypertension
Pulmonary Htn - [Hypertension]

Nonparalytic Poliomyelitis

Acute Nonparalytic Poliomyelitis

Non-Paralytic Aseptic Meningitis

Neutrophilic Dermatosis, Acute Febrile

Sweet Syndrome	Acute Febrile Neutrophilic Dermatosis
Ss	AFND
Pyrin-Associated Autoinflammatory Disease	PAAND
Gomm-Button Disease	Sweet'S Syndrome
Gomm Button Disease	Sweets Syndrome
Acromelic Frontonasal Dysostosis	Sweet Disease

Paralytic Poliomyelitis

Poliomyelitis, Paralytic

Dermatitis, Atopic, 3

ATOD3	Dermatitis, Atopic, Susceptibility To, 3
Atopic Dermatitis 3	Dermatitis, Atopic, With Asthma
Dermatitis, Atopic 3	Atopic Dermatitis With Asthma

Lissencephaly

Pachygyria	Broad Gyri Of Cerebrum
Large Gyri Of Cerebrum	Macrogyria

Bardet-Biedl Syndrome

Bbs	Biedl-Bardet Syndrome

Behcet Syndrome

Behcet Disease	Behcet'S Syndrome
Behcet'S Disease	Behçet Disease
Bd	Adamantiades-Behcet Disease
Triple Symptom Complex	Behçet'S Disease
Behet'S Syndrome	Bd Syndrome
Behçet Syndrome	Behçet'S Syndrome
Behcet Triple Symptom Complex	Malignant Aphthosis
Old Silk Route Disease	Adamantiades-Behçet Disease

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

Joubert Syndrome 1

Joubert Syndrome	Jbts
Cerebellooculorenal Syndrome 1	JBTS1
Joubert-Boltshauser Syndrome	Cerebelloparenchymal Disorder Iv
Cpd4	Cors1
Joubert Syndrome And Related Disorders	Jsrd
Familial Aplasia Of The Vermis	Joubert Syndrome Related Disorders
Js	Cerebellar Vermis Agenesis
Cerebelloparenchymal Disorder 4	Agenesis Of Cerebellar Vermis
Cerebello-Oculo-Renal Syndrome	Cors
Joubert-Bolthauser Syndrome	Cpd Iv
Classic Joubert Syndrome	Joubert Syndrome Type A
Pure Joubert Syndrome	Cerebello-Oculo-Renal Syndrome 1
Joubert Syndrome-1	Joubert Syndrome, Type 1
Joubert'S Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04092	DYNLT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DYNLT1	VGNC	VGNC:81062
Felis catus	DYNLT1	VGNC	VGNC:61684
Rattus norvegicus	DYNLT1	RGD	RGD:620261
Canis familiaris	DYNLT1	VGNC	VGNC:54841

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