TESK1 - testis associated actin remodelling kinase 1 Gene

Homo sapiens

Gene ID: 7016 | Gene type: protein coding

About TESK1

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:35,605,262-35,610,033 (from NCBI)

This gene has 6 transcripts (splice variants), 267 orthologues and 23 paralogues. Ubiquitous expression in fat (RPKM 24.9), testis (RPKM 24.6) and 25 other tissues.

Summary

This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain and a C-terminal proline-rich domain. Its protein kinase domain is most closely related to those of the LIM motif-containing protein kinases (LIMKs). The encoded protein can phosphorylate myelin basic protein and histone in vitro. The testicular germ cell-specific expression and developmental pattern of expression of the mouse gene suggests that this gene plays an important role at and after the meiotic phase of spermatogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

TESK1 Products(2)

mRNA	Protein	Name
NM_001318230.2	NP_001305159.1	dual specificity testis-specific protein kinase 1 isoform 2
NM_006285.3	NP_006276.2	dual specificity testis-specific protein kinase 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12027893	GOA
enables protein kinase activity	IMP IMP: Inferred from mutant phenotype	15584898	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in establishment of vesicle localization	IMP IMP: Inferred from mutant phenotype	25849865	GOA
involved in negative regulation of cilium assembly	IMP IMP: Inferred from mutant phenotype	25849865	GOA
involved in positive regulation of protein localization to nucleus	IMP IMP: Inferred from mutant phenotype	25849865	GOA
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	25849865	GOA
involved in positive regulation of substrate adhesion-dependent cell spreading	IMP IMP: Inferred from mutant phenotype	15584898	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centrosome	IDA IDA: Inferred from direct assay	25849865	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15584898	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TESK1 Protein Structure

Pkinase

0
100
200
300
400
500
626 a.a.

Protein Preferred Names

Protein Names

dual specificity testis-specific protein kinase 1

testicular protein kinase 1

TESK1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TESK1	Q15569	SPRY4	Homo sapiens	Q9C004	CoIP	12027893
Intra	TESK1	Q15569	SPRY4	Homo sapiens	Q9C004	Y2H	12027893
Intra	TESK1	Q15569	YWHAE	Homo sapiens	P62258	Crosslink	36931259

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Spermatogenic Failure 8

SPGF8

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14380	TESK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TESK1	VGNC	VGNC:56071
Macaca mulatta	TESK1	VGNC	VGNC:78314
Felis catus	TESK1	VGNC	VGNC:66089
Bos taurus	TESK1	VGNC	VGNC:35754
Mus musculus	TESK1	MGD	MGI:1201675
Rattus norvegicus	TESK1	RGD	RGD:62059

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