2. Gene
  3. SPRY4 - sprouty RTK signaling antagonist 4 Gene

SPRY4 - sprouty RTK signaling antagonist 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HH17

Gene ID: 81848 | Gene type: protein coding

About SPRY4

Cytogenetic location: 5q31.3 Genomic coordinates (GRCh38): 5:142,310,430-142,325,021 (from NCBI)

This gene has 6 transcripts (splice variants), 195 orthologues, 3 paralogues and is associated with 5 phenotypes. Broad expression in lung (RPKM 7.4), adrenal (RPKM 7.0) and 24 other tissues.

Summary

This gene encodes a member of a family of cysteine- and proline-rich proteins. The encoded protein is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. Activity of this protein impairs the formation of active GTP-RAS. Nucleotide variation in this gene has been associated with hypogonadotropic hypogonadism 17 with or without anosmia. Alternative splicing results in a multiple transcript variants. [provided by RefSeq, Jun 2014]

SPRY4 Products(4)

mRNA Protein Name
NM_001127496.3 NP_001120968.1 protein sprouty homolog 4 isoform 2
NM_001293289.3 NP_001280218.1 protein sprouty homolog 4 isoform 2
NM_001293290.3 NP_001280219.1 protein sprouty homolog 4 isoform 2
NM_030964.5 NP_112226.2 protein sprouty homolog 4 isoform 1

SPRY4 Protein Structure

Sprouty

Sprouty: Sprouty protein (Spry) (164 - 276)

  • 0
  • 100
  • 200
  • 299 a.a.
Protein Preferred Names Protein Names

protein sprouty homolog 4

sprouty homolog 4

SPRY4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SPRY4 Q9C004 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
Intra
SPRY4 Q9C004 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
Intra
SPRY4 Q9C004 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
Intra
SPRY4 Q9C004 DMWD Homo sapiens G5E9A7
Validated Y2H
32814053
Intra
SPRY4 Q9C004 DMWD Homo sapiens G5E9A7
Y2H Array
32814053
Intra
SPRY4 Q9C004 DMWD Homo sapiens G5E9A7
Y2H Pooling
32814053
Intra
SPRY4 Q9C004 ATN1 Homo sapiens Q86V38
Y2H Array
32814053
Intra
SPRY4 Q9C004 ATN1 Homo sapiens Q86V38
Y2H Pooling
32814053
Intra
SPRY4 Q9C004 ATN1 Homo sapiens Q86V38
Validated Y2H
32814053
Intra
SPRY4 Q9C004 CTSD Homo sapiens P07339
Validated Y2H
32814053
Intra
SPRY4 Q9C004 CTSD Homo sapiens P07339
Y2H Pooling
32814053
Intra
SPRY4 Q9C004 CTSD Homo sapiens P07339
Y2H Array
32814053
Intra
SPRY4 Q9C004 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra
SPRY4 Q9C004 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra
SPRY4 Q9C004 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra
SPRY4 Q9C004 GSN Homo sapiens P06396
Y2H Array
32814053
Intra
SPRY4 Q9C004 GSN Homo sapiens P06396
Validated Y2H
32814053
Intra
SPRY4 Q9C004 GSN Homo sapiens P06396
Y2H Pooling
32814053
Intra
SPRY4 Q9C004 HSPB1 Homo sapiens P04792
Y2H Array
32814053
Intra
SPRY4 Q9C004 HSPB1 Homo sapiens P04792
Y2H Pooling
32814053
Intra
SPRY4 Q9C004 HSPB1 Homo sapiens P04792
Validated Y2H
32814053
Intra
SPRY4 Q9C004 TESK1 Homo sapiens Q15569
CoIP
12027893
Intra
SPRY4 Q9C004 TESK1 Homo sapiens Q15569
Y2H
12027893
Intra
SPRY4 Q9C004 RNF11 Homo sapiens Q9Y3C5
Y2H Array
32814053
Intra
SPRY4 Q9C004 RNF11 Homo sapiens Q9Y3C5
Y2H Pooling
32814053
Intra
SPRY4 Q9C004 RNF11 Homo sapiens Q9Y3C5
Validated Y2H
32814053
Intra
SPRY4 Q9C004 PMP22 Homo sapiens A0A6Q8PF08
Validated Y2H
32814053
Intra
SPRY4 Q9C004 PMP22 Homo sapiens A0A6Q8PF08
Y2H Pooling
32814053
Intra
SPRY4 Q9C004 PMP22 Homo sapiens A0A6Q8PF08
Y2H Array
32814053
Intra
SPRY4 Q9C004 CBL Homo sapiens P22681
Anti Tag CoIP
18273061
Intra
SPRY4 Q9C004 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
SPRY4 Q9C004 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
SPRY4 Q9C004 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
SPRY4 Q9C004 ZDHHC17 Homo sapiens Q8IUH5
Y2H Array
24705354
Intra
SPRY4 Q9C004 ZDHHC17 Homo sapiens Q8IUH5
Lumier
24705354
Intra
SPRY4 Q9C004 TTR Homo sapiens P02766
Validated Y2H
32814053
Intra
SPRY4 Q9C004 TTR Homo sapiens P02766
Y2H Array
32814053
Intra
SPRY4 Q9C004 TTR Homo sapiens P02766
Y2H Pooling
32814053
Intra
SPRY4 Q9C004 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
SPRY4 Q9C004 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
SPRY4 Q9C004 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
SPRY4 Q9C004 COQ8A Homo sapiens Q8NI60
Y2H Pooling
32814053
Intra
SPRY4 Q9C004 COQ8A Homo sapiens Q8NI60
Validated Y2H
32814053
Intra
SPRY4 Q9C004 COQ8A Homo sapiens Q8NI60
Y2H Array
32814053
Intra
SPRY4 Q9C004 PRPS1 Homo sapiens P60891
Y2H Array
32814053
Intra
SPRY4 Q9C004 PRPS1 Homo sapiens P60891
Y2H Pooling
32814053
Intra
SPRY4 Q9C004 PRPS1 Homo sapiens P60891
Validated Y2H
32814053
Intra
SPRY4 Q9C004 PIP4K2B Homo sapiens P78356
Anti Tag CoIP
28514442
Intra
SPRY4 Q9C004 PIP4K2B Homo sapiens P78356
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hypogonadotropic Hypogonadism 17 With Or Without Anosmia

HH17

Hypogonadism, Hypogonadotropic, Type 17 With/Without Anosmia
Kallmann Syndrome

Hypogonadism With Anosmia

Kallman'S Syndrome

Anosmic Hypogonadism

Anosmic Idiopathic Hypogonadotropic Hypogonadism

Hypogonadotropic Hypogonadism And Anosmia

Hypogonadotropic Hypogonadism-Anosmia Syndrome

Olfacto-Genital Pathological Sequence

Familial Hypogonadism With Anosmia

Kallman Syndrome

Dysplasia Olfactogenitalis Of De Morsier

Kallmann'S Syndrome

Congenital Hypogonadotropic Hypogonadism With Anosmia
Normosmic Congenital Hypogonadotropic Hypogonadism

Normosmic Idiopathic Hypogonadotropic Hypogonadism

Nihh
Hypogonadotropic Hypogonadism 7 With Or Without Anosmia

Idiopathic Hypogonadotropic Hypogonadism

HH7

Hypogonadism, Isolated Hypogonadotropic

Ihh

Hypogonadism, Isolated, Hypogonadotropic

Hypogonadotropic Hypogonadism

Isolated Hypogonadotropic Hypogonadism

Hypogonadotropic Hypogonadism 7 Without Anosmia

Congenital Hypogonadotropic Hypogonadism Normosmic

Hh

Klinefelter Syndrome

Isolated Gonadotropin Deficiency
Hypogonadotropic Hypogonadism

Klinefelter Syndrome

Klinefelter'S Syndrome

Xxy Syndrome

Xxy Trisomy

Hypogonadotropism

47, Xxy

Congenital Idiopathic Hypogonadotropic Hypogonadism

Isolated Congenital Gonadotropin Deficiency

47,Xxy Syndrome

47, Xxy Syndrome

Klinefelters Syndrome

Hypogonadism

Klinefelter Syndrome In Males

Klinefelter Syndrome, Unspecified

Klinefelter Syndrome Karyotype 47, Xxy
Hypogonadism
Legius Syndrome

Neurofibromatosis Type 1-Like Syndrome

Nfls

LGSS

Neurofibromatosis 1-Like Syndrome

Neurofibromatosis Type 1 Like Syndrome

Nf1-Like Syndrome

Neurofibromatosis, Type 1-Like Syndrome
Childhood Germ Cell Cancer

Pediatric Germ Cell Tumor

Paediatric Germ Cell Cancer

Paediatric Germ Cell Neoplasm

Pediatric Germ Cell Cancer

Pediatric Germ Cell Neoplasm
Esophageal Basaloid Squamous Cell Carcinoma

Basaloid Squamous Carcinoma Of Esophagus

Esophageal Basaloid Carcinoma
Testicular Disease

Testicular Dysfunction

Testicular Diseases

Disorder Of Testis

Testis Disorder

Testicular Disorders
Testicular Germ Cell Cancer

Germ Cell Tumor Of Testis

Testicular Germ Cell Tumor

Testicular Germ Cell Neoplasm

Testicular Malignant Germ Cell Tumor
Sensorineural Hearing Loss

Sensory Hearing Loss

Sensorineural Deafness

Sensorineural Hearing Loss Disorder

Hearing Loss, Sensorineural

Central Hearing Loss

High Frequency Deafness

High Frequency Hearing Loss

High-Frequency Hearing Loss

Perceptive Deafness

Perceptive Hearing Loss

Perceptive Hearing Loss Or Deafness

Hearing Loss Sensorineural

Deafness Sensorineural

Hearing Loss High-Frequency

Hearing Loss, Central

Hearing Loss, High-Frequency
Cryptorchidism, Unilateral Or Bilateral

Cryptorchidism

Undescended Testicle

Undescended Testis

Cryptorchism

Undescended Testicles

CRYPTO

Impaired Testicular Descent

Cryptosporidiosis

Retained Testis

Unilateral Cryptorchidism

Unilateral Undescended Testis

Nondescent Unilateral Testicle

Unilateral Cryptorchism

Ectopic Testis, Unilateral

Bilateral Cryptorchidism

Bilateral Cryptorchism

Bilateral Nondescent Testicle

Bilateral Undescended Testes

Bilateral Ectopic Testes
Testicular Cancer

Testis Cancer

Testicular Carcinoma

Testicular Neoplasms

Malignant Neoplasm Of Testis

Childhood Neoplasm Of The Testis

Neoplasm Of Testis

Pediatric Testicular Neoplasm

Testicular Tumor

Testis Neoplasm

Testicular Tumors

Testicular Neoplasm

Testicular Malignant Germ Cell Tumor

Childhood Testicular Neoplasm

Carcinoma Of The Testis

Cancer Of Testis

Malignant Neoplasm Of Testis, Nos

Malignant Neoplasm Of Testis, Unspecified

Malignant Tumour Of Testis

Testicle Cancer

Primary Malignant Neoplasm Of Testis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13724 SPRY4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SPRY4 VGNC VGNC:35244
Macaca mulatta SPRY4 VGNC VGNC:77925
Canis familiaris SPRY4 VGNC VGNC:46767
Rattus norvegicus SPRY4 RGD RGD:1305324
Mus musculus SPRY4 MGD MGI:1345144
Felis catus SPRY4 VGNC VGNC:102332