TFF2 - trefoil factor 2 Gene

Homo sapiens

Also known as SP; SML1

Gene ID: 7032 | Gene type: protein coding

About TFF2

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:42,346,357-42,350,994 (from NCBI)

This gene has 3 transcripts (splice variants), 121 orthologues and 2 paralogues. Restricted expression toward stomach (RPKM 2591.2).

Summary

Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two Other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]

TFF2 Products(1)

mRNA	Protein	Name
NM_005423.5	NP_005414.1	trefoil factor 2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21982860	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TFF2 Protein Structure

Trefoil

0
100
129 a.a.

Protein Preferred Names

Protein Names

trefoil factor 2

spasmolysin

TFF2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TFF2	Q03403	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
Intra	TFF2	Q03403	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
Intra	TFF2	Q03403	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
Intra	TFF2	Q03403	FCRL4	Homo sapiens	Q96PJ5	Protein Array	21982860

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TFF2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71354	TFF2 Protein, Human (HEK293, His)	Q03403 (E24-Y129)	≥95%
HY-P71929A	TFF2 Protein, Human (His)	Q03403 (E24-Y129)	≥95%

Related Diseases

Diseases

Alias

Gastritis

Acute Gastric Mucosal Erosion	Erosive Gastritis
Erosive Gastropathy	Gastritis Erosive
Idiopathic Erosive/Hemorrhagic Gastritis	Inflammation Of Gastric Mucosa
Gastroduodenitis	Gastritis Nos
Noninfectious Gastroenteritis	Nonbacterial Gastroenteritis Of Infant
Acute Gastric Infection	Acute Simple Gastritis
Chronic Antral Gastritis	Chronic Fundal Gastritis
Chronic Simple Gastritis	Acute Gastroduodenitis
Acute Antral Gastritis	Acute Erosive Gastritis
Bile Reflux Gastritis	Gastritis Due To Biliary Reflux

Atrophic Gastritis

Gastritis, Atrophic	Gastric Atrophy
Gastritis Atrophic

Alcoholic Gastritis

Alcoholic Gastritis, With Hemorrhage	Alcoholic Gastritis, Without Mention Of Hemorrhage
Alcohol Gastritis	Etoh Gastritis

Febrile Seizures, Familial, 1

FEB1	Convulsions, Familial Febrile, 1
Familial Febrile Seizures 1	Familial Febrile Convulsions 1

Papillary Adenofibroma

Autoimmune Gastritis

Gastric Ulcer

Stomach Ulcer	Acute Gastric Ulcer With Haemorrhage And Perforation
Acute Gastric Ulcer With Hemorrhage And Obstruction	Acute Gastric Ulcer With Hemorrhage And Perforation
Acute Gastric Ulcer With Hemorrhage And Perforation, With Obstruction	Acute Gastric Ulcer With Hemorrhage And Perforation, Without Mention Of Obstruction
Acute Gastric Ulcer With Hemorrhage And With Perforation But Without Obstruction	Acute Gastric Ulcer With Hemorrhage, With Obstruction
Acute Gastric Ulcer With Hemorrhage, With Perforation And With Obstruction	Acute Gastric Ulcer With Perforation
Acute Gastric Ulcer With Perforation And Obstruction	Acute Gastric Ulcer With Perforation, With Obstruction
Acute Gastric Ulcer Without Hemorrhage And Without Perforation	Acute Gastric Ulcer Without Hemorrhage, Without Perforation And Without Obstruction
Acute Gastric Ulcer Without Mention Of Hemorrhage Or Perforation, Without Mention Of Obstruction	Bleeding Acute Gastric Ulcer
Chronic Gastric Ulcer Without Hemorrhage And Without Perforation	Chronic Gastric Ulcer Without Hemorrhage And Without Perforation But With Obstruction
Chronic Gastric Ulcer Without Mention Of Hemorrhage Or Perforation, With Obstruction	Gastric Ulcers
Cushings Ulcer	Cushing'S Ulcer Of Stomach
Peptic Ulcer Of Stomach	Mucosal Defect Of The Stomach

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Colitis

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Barrett Esophagus

Barrett'S Esophagus	Barrett Esophagus/Esophageal Adenocarcinoma
Barrett Metaplasia	Barrett'S Ulcer Of Esophagus
Ulcerative Esophagitis	Barrett'S Esophagus With Esophagitis
Barrett'S Oesophagus	Barretts Syndrome
Barrett Syndrome	BE
Peptic Ulcer Of Esophagus	Adenocarcinoma Of Esophagus

Gastritis, Familial Giant Hypertrophic

Menetrier Disease	Gastric Mucosal Hypertrophy
Giant Hypertrophic Gastritis	Hypertrophic Gastropathy
Gastritis, Hypertrophic	Familial Giant Hypertrophic Gastritis
Giant Rugal Hypertrophy Of Stomach	Hypertrophic Gastritis
Gastroenteropathy, Protein Losing	Giant Hypertrophic Gastropathy
Giant Hypertrophy Of The Gastric Mucosa	Hypoproteinemic Hypertrophic Gastropathy
Menetrier'S Disease	Giant Hypertrophic Hypersecretory Gastritis

Gastrointestinal Adenoma

Gi Adenoma

Digestive System Adenoma

Microinvasive Gastric Cancer

Early Gastric Cancer

Surface Gastric Cancer

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Diffuse Gastric Cancer

Hereditary Diffuse Gastric Adenocarcinoma	Hereditary Diffuse Gastric Cancer
Signet Cell Adenocarcinoma	Signet Ring Cell Carcinoma
Signet Ring Cell Gastric Carcinoma	Signet Ring Gastric Carcinoma
Fdgc	Familial Diffuse Cancer Of Stomach
Familial Diffuse Gastric Cancer	Gastric Cancer, Familial Diffuse
Gastric Cancer, Hereditary Diffuse	Hdgc
Hereditary Diffuse Cancer Of Stomach	Diffuse Gastric Cancer Syndrome
Cancer, Gastric, Diffuse	Carcinoma, Signet Ring Cell
Gastric Signet Ring Carcinoma

Retinitis Pigmentosa 39

RP39	Retinitis Pigmentosa, Type 39

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14423	TFF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TFF2	VGNC	VGNC:35791
Canis familiaris	TFF2	VGNC	VGNC:47297
Mus musculus	TFF2	MGD	MGI:1306805
Felis catus	TFF2	VGNC	VGNC:66120
Macaca mulatta	TFF2	VGNC	VGNC:78327
Rattus norvegicus	TFF2	RGD	RGD:620709
Others	TFF2	NCBI

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