1. Gene
  2. TGFB2 - transforming growth factor beta 2 Gene

TGFB2 - transforming growth factor beta 2 Gene

Homo sapiens

Also known as LDS4; G-TSF; TGF-beta2

Gene ID: 7042 | Gene type: protein coding

About TGFB2

Cytogenetic location: 1q41 Genomic coordinates (GRCh38): 1:218,345,336-218,444,619 (from NCBI)

This gene has 4 transcripts (splice variants), 199 orthologues, 31 paralogues and is associated with 3 phenotypes. Broad expression in prostate (RPKM 9.5), lung (RPKM 6.3) and 18 other tissues.

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with Other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. Mutations in this gene may be associated with Loeys-Dietz syndrome. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]

TGFB2 Products(4)

mRNA Protein Name
NR_138148.2
NM_001135599.4 NP_001129071.1 transforming growth factor beta-2 proprotein isoform 1 precursor
NR_138149.2
NM_003238.6 NP_003229.1 transforming growth factor beta-2 proprotein isoform 2 preproprotein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables amyloid-beta binding IDA
IDA: Inferred from direct assay
16227582 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
2022183 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
2119582 GOA
enables signaling receptor binding IMP
IMP: Inferred from mutant phenotype
16227582 GOA
enables transforming growth factor beta receptor binding IDA
IDA: Inferred from direct assay
10092230 GOA
enables type II transforming growth factor beta receptor binding IDA
IDA: Inferred from direct assay
11157754 GOA
enables type II transforming growth factor beta receptor binding IMP
IMP: Inferred from mutant phenotype
8167376 GOA
enables type II transforming growth factor beta receptor binding IPI
IPI: Inferred from physical interaction
1333888 GOA
enables type III transforming growth factor beta receptor binding IMP
IMP: Inferred from mutant phenotype
8167376 GOA
enables type III transforming growth factor beta receptor binding IPI
IPI: Inferred from physical interaction
7852346 GOA
Biological Process GO Annotation Evidence Reference Source
involved in activation of protein kinase activity IDA
IDA: Inferred from direct assay
17960115 GOA
involved in cardiac epithelial to mesenchymal transition IDA
IDA: Inferred from direct assay
10092230 GOA
involved in cardiac muscle cell proliferation IDA
IDA: Inferred from direct assay
15896309 GOA
involved in cardioblast differentiation IDA
IDA: Inferred from direct assay
15896309 GOA
involved in cell migration IDA
IDA: Inferred from direct assay
10092230 GOA
involved in cell morphogenesis IDA
IDA: Inferred from direct assay
15896309 GOA
involved in cell-cell junction organization IDA
IDA: Inferred from direct assay
18505915 GOA
involved in collagen fibril organization IDA
IDA: Inferred from direct assay
16891397 GOA
involved in embryonic digestive tract development IEP
IEP: Inferred from expression pattern
20875417 GOA
acts upstream of epithelial cell differentiation IDA
IDA: Inferred from direct assay
18358889 GOA
involved in epithelial to mesenchymal transition IDA
IDA: Inferred from direct assay
10092230 GOA
involved in extrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
17217916 GOA
involved in eye development IDA
IDA: Inferred from direct assay
15944186 GOA
involved in glial cell migration IDA
IDA: Inferred from direct assay
18431253 GOA
involved in hair follicle development IDA
IDA: Inferred from direct assay
10433821 GOA
involved in heart development IDA
IDA: Inferred from direct assay
15896309 GOA
involved in heart morphogenesis IDA
IDA: Inferred from direct assay
10092230 GOA
involved in negative regulation of angiogenesis IDA
IDA: Inferred from direct assay
25217442 GOA
involved in negative regulation of cell growth IDA
IDA: Inferred from direct assay
18358889 GOA
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
15944186 GOA
involved in negative regulation of epithelial cell proliferation IDA
IDA: Inferred from direct assay
17217916 GOA
involved in negative regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
16943770 GOA
involved in negative regulation of gene expression IDA
IDA: Inferred from direct assay
25217442 GOA
involved in negative regulation of macrophage cytokine production IDA
IDA: Inferred from direct assay
20875417 GOA
involved in positive regulation of Notch signaling pathway IDA
IDA: Inferred from direct assay
25217442 GOA
involved in positive regulation of SMAD protein signal transduction IDA
IDA: Inferred from direct assay
11157754 GOA
involved in positive regulation of cardioblast differentiation IDA
IDA: Inferred from direct assay
15896309 GOA
involved in positive regulation of cell adhesion mediated by integrin IDA
IDA: Inferred from direct assay
17960115 GOA
involved in positive regulation of cell growth IDA
IDA: Inferred from direct assay
15896309 GOA
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
15896309 GOA
involved in positive regulation of epithelial cell migration IDA
IDA: Inferred from direct assay
17960115 GOA
involved in positive regulation of epithelial to mesenchymal transition IDA
IDA: Inferred from direct assay
17999987 GOA
involved in positive regulation of heart contraction IDA
IDA: Inferred from direct assay
15896309 GOA
involved in positive regulation of integrin biosynthetic process IDA
IDA: Inferred from direct assay
17960115 GOA
involved in positive regulation of miRNA transcription IDA
IDA: Inferred from direct assay
25217442 GOA
involved in positive regulation of neuron apoptotic process IDA
IDA: Inferred from direct assay
16227582 GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
18223299 GOA
involved in positive regulation of protein secretion IDA
IDA: Inferred from direct assay
18505915 GOA
involved in positive regulation of stress-activated MAPK cascade IDA
IDA: Inferred from direct assay
17192487 GOA
involved in positive regulation of timing of catagen IDA
IDA: Inferred from direct assay
15955085 GOA
involved in regulation of cell population proliferation IDA
IDA: Inferred from direct assay
18223299 GOA
NOT involved in regulation of complement-dependent cytotoxicity IMP
IMP: Inferred from mutant phenotype
16034134 GOA
involved in regulation of timing of catagen IDA
IDA: Inferred from direct assay
15955085 GOA
involved in regulation of transforming growth factor beta2 production IMP
IMP: Inferred from mutant phenotype
12411310 GOA
involved in response to hypoxia IMP
IMP: Inferred from mutant phenotype
12411310 GOA
involved in response to progesterone IDA
IDA: Inferred from direct assay
18039789 GOA
involved in response to wounding IEP
IEP: Inferred from expression pattern
16891397 GOA
involved in salivary gland morphogenesis IEP
IEP: Inferred from expression pattern
18080134 GOA
involved in signaling IDA
IDA: Inferred from direct assay
16227582 GOA
involved in transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
11157754 GOA
Cellular Component GO Annotation Evidence Reference Source
located in collagen-containing extracellular matrix IDA
IDA: Inferred from direct assay
18049952 GOA
located in extracellular region IDA
IDA: Inferred from direct assay
16227582 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
24263861 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TGFB2 Protein Structure

TGFb_propeptide

TGFb_propeptide: TGF-beta propeptide (20 - 224)

TGF_beta

TGF_beta: Transforming growth factor beta like domain (315 - 414)

  • 0
  • 100
  • 200
  • 300
  • 414 a.a.
Protein Preferred Names Protein Names

transforming growth factor beta-2 proprotein

BSC-1 cell growth inhibitor

cetermin

glioblastoma-derived T-cell suppressor factor

polyergin

prepro-transforming growth factor beta-2

TGFB2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TGFB2 P61812 APP Homo sapiens P05067
PLA
25241761
Intra
TGFB2 P61812 APP Homo sapiens P05067
Photoaffinity Labelling
2119582
Intra
TGFB2 P61812 APP Homo sapiens P05067
Chromatography
2119582
Intra
TGFB2 P61812 APP Homo sapiens P05067
Anti Bait CoIP
2119582
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TGFB2 Proteins

Cat. No. Product Name Accession Purity
HY-P7119 TGF beta 2/TGFB2 Protein, Human P61812 (A303-S414) ≥95%
HY-P700151AF Animal-Free TGF beta 2/TGFB2 Protein, Human (His) P61812 (A303-S414) ≥95%
HY-P700785 TGF beta 2/TGFB2 Protein, Human (HEK293, Avi) P61812 (A303-S414) ≥95%

Related Diseases

Diseases Alias
Keratosis, Seborrheic

Seborrheic Keratosis

Keratosis, Seborrheic, Somatic

Basal Cell Papilloma

Keratosis Seborrheica

KERSEB

Atrial Septal Defect 1

ASD1

Atrial Heart Septal Defect 1

Asd

Vitreoretinopathy, Neovascular Inflammatory

Proliferative Vitreoretinopathy

Adniv

Autosomal Dominant Neovascular Inflammatory Vitreoretinopathy

VRNI

Pvr

Neovascular Inflammatory Vitreoretinopathy

Vitreoretinopathy, Neovascular Inflammatory, Autosomal Dominant

Retinitis Proliferans

Neovascular Inflammatory Vitreoretinopathy Autosomal Dominant

Vitreoretinopathy Proliferative

Vitreoretinopathy, Proliferative

Proliferative Vitreo-Retinopathy

Orthostatic Intolerance

Mitral Valve Prolapse

Neurocirculatory Asthenia

Mitral Valve Prolapse Syndrome

Irritable Heart

Systolic Click-Murmur Syndrome

Soldiers Heart

Cardiovascular Malfunction Arising From Mental Factors

Cardiovascular Neurosis

Da Costa'S Syndrome

Krishaber'S Disease

Barlow'S Syndrome

Floppy Mitral Valve

Mitral Leaflet Syndrome

Myxomatous Mitral Valve Prolapse

Postural Orthostatic Tachycardia Syndrome Due To Net Deficiency

Familial Orthostatic Tachycardia Due To Norepinephrine Transporter Deficiency

Orthostatic Intolerance Due To Net Deficiency

Pots Due To Net Deficiency

OI

Intolerance, Orthostatic

Mitral Valve Prolapse, Familial, X-Linked

Ballooning Mitral Valve

Barlow Syndrome

Flail Mitral Leaflet

Myxomatous Mitral Valve

Mitral Valve Prolapse-Click Syndrome

Prolapsing Mitral Valve Leaflet Syndrome

Billowing Mitral Valve Leaflet

Posterior Mitral Leaflet Deformity

Ballooning Posterior Leaflet Syndrome

Blue Valve Syndrome

Floppy Mitral Valve Syndrome

Mitral Valvular Prolapse

Systolic Click Syndrome

Glaucoma, Primary Open Angle

Glaucoma 1, Open Angle, E

Primary Open Angle Glaucoma

POAG

Adult-Onset Primary Open Angle Glaucoma

Chronic Simple Glaucoma

GLC1E

Primary Open Angle Glaucoma 1e

Glaucoma, Open Angle, Primary

Myopia

Near-Sightedness

Short-Sightedness

Nearsightedness

Nearsighted

Near Vision

Close Sighted

Myopic

Short-Sighted

Near Sighted

Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer

Keratoconus

Kc

Conical Cornea

Noninflammatory Corneal Thining

Bulging Cornea

Cornea Conical

Acquired Conus Of Cornea

Persistent Hyperplastic Primary Vitreous

Congenital Retinal Detachment

Ncrna Disease

Non-Syndromic Congenital Retinal Non-Attachment

Pfvs

Phpv

Persistent Fetal Vasculature Syndrome

Microphthalmia, Syndromic 6

MCOPS6

Microphthalmia And Pituitary Anomalies

Microphthalmia With Brain And Digit Anomalies

Microphthalmia With Brain And Digit Developmental Anomalies

Syndromic Microphthalmia Type 6

Syndromic Microphthalmia 6

Anophthalmia Clinical With Micrognathia Malformed Ears Digital Anomalies And Abnormal External Genitalia

Bakrania-Ragge Syndrome

Orofacial Cleft 11

Anophthalmia, Clinical, With Micrognathia, Malformed Ears, Digital Anomalies, And Abnormal External Genitalia

Microphthalmia Syndromic 6

Microphthalmia, Syndromic, 6

Clinical Anophthalmia With Micrognathia, Malformed Ears, Digital Anomalies And Abnormal External Genitalia

Microphthalmia Syndromic, Type 6

Gingival Overgrowth

Gingival Enlargement

Gingival Hyperplasia

Gingival Bulge

Gingival Enlargement Nos

Gingival Hypertrophy

Gum Hypertrophy

Hyperplasia Gum

Gingival Thickening

Hyperplasia Of Gingiva

Hypertrophy Of Gingiva

Hypertrophy Of Mucous Membrane Of Gums

Juvenile Glaucoma

Glaucoma Of Childhood

Hydrophthalmos

Loeys-Dietz Syndrome 5

Rienhoff Syndrome

LDS5

Rnhf

Reinhoff Syndrome

Loeys-Dietz Syndrome, Type 5

Acquired Hyperkeratosis

Acquired Keratoderma

Keratoderma - Acquired

Keratoderma, Acquired

Keratosis Blennorrhagica

Loeys-Dietz Syndrome 4

LDS4

Aneurysm, Aortic And Cerebral, With Arterial Tortuosity And Skeletal Manifestations

Loeys-Dietz Syndrome Type 4

Aortic And Cerebral Aneurysm With Arterial Tortuosity And Skeletal Manifestations

Loeys-Dietz Syndrome, Type 4

Cataract

Cataracts

Cat - [Cataract]

Cataract Form

Lens Opacity

Lens Opacities

Bullous Keratopathy

Bk - [Bullous Keratopathy]

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Loeys-Dietz Syndrome 2

LDS2

Aat3

Marfan Syndrome Type 2

Aortic Aneurysm, Familial Thoracic 3

Marfan Syndrome Type Ii

Loeys-Dietz Syndrome Type 2

Mfs2

Marfan Syndrome, Type Ii, Formerly

Familial Throacic Aortic Aneurysm 3

Familial Aortic Aneurysm Thoracic Type 3

Taad2

Thoracic Aortic Aneurysms And Dissection 2

Aneurysm, Aortic, Thoracic, Familial, Type 3

Loeys-Dietz Syndrome, Type 2

Orofacial Cleft

Cleft, Orofacial

Cleft Palate, Isolated

Cleft Palate

Isolated Cleft Palate

CPI

Cp

Palatoschisis

Cleft Palate Isolated

Uranostaphyloschisis

Congenital Fissure Of Palate

Cleft Of Secondary Palate

Chronic Closed-Angle Glaucoma

Anatomical Narrow Angle Glaucoma

Chronic Angle-Closure Glaucoma

Chronic Narrow Angle Glaucoma

Secondary Angle-Closure Glaucoma - Synechial

Craniosynostosis

Premature Closure Of Cranial Sutures

Craniostenosis

Craniosynostosis Syndrome

Cso

Craniosynostoses

Congenital Ossification Of Cranial Sutures

Congenital Ossification Of Sutures Of Skull

Craniostosis

Imperfect Fusion Of Skull

Congenital Imperfect Closure Skull

Imperfect Closure Skull

Premature Closure Cranium Sutures

Deficiency Of Craniofacial Axis

Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder

Phacogenic Glaucoma
Interstitial Lung Disease 2

Idiopathic Pulmonary Fibrosis

Ipf

Fibrocystic Pulmonary Dysplasia

Pulmonary Fibrosis, Idiopathic

Pulmonary Fibrosis, Idiopathic, Susceptibility To

ILD2

Idiopathic Pulmonary Fibrosis, Familial

Fibrosing Alveolitis, Cryptogenic

Uip

Cryptogenic Fibrosing Alveolitis

Fibrosing Alveolitis

Interstitial Pneumonitis, Usual

Familial Idiopathic Pulmonary Fibrosis

Idiopathic Fibrosing Alveolitis, Chronic Form

Usual Interstitial Pneumonia

Fibrosing Alveolitis Cryptogenic

Hamman-Rich Disease

Idiopathic Pulmonary Fibrosis Familial

Interstitial Pneumonitis Usual

Fibrosis Idiopathic Pulmonary

Fibrosis, Pulmonary, Idiopathic

Hamman-Rich Syndrome

Chronic Idiopathic Pulmonary Fibrosis

Acute Interstitial Pneumonia

Interstitial Pulmonary Fibrosis

Ipf - [Idiopathic Pulmonary Fibrosis]

Idiopathic Lung Fibrosis

Fibrosing Lung Disease

Pulmonary Fibrosis Nos

Fibrosing Pneumonitis

Arterial Tortuosity Syndrome

Arterial Tortuosity

Ats

ATORS

Tortuosity, Arterial, Syndrome

Preretinal Fibrosis

Cellophane Maculopathy

Macular Puckering Of Retina

Macular Retinal Puckering

Epiretinal Membrane

Androgenic Alopecia

Androgenetic Alopecia

Alopecia Androgenetica, Male Pattern Baldness

Ocular Hypertension

Hypertension, Ocular

Intraocular Pressure Increase

Oh - [Ocular Hypertension]

Oht - [Ocular Hypertension]

Aortic Dissection
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1

Double Outlet Right Ventricle

Double Outlet Right Ventricle With Subpulmonary Ventricular Septal Defect

Taussig-Bing Syndrome

Dextrotransposition Of Aorta

Taussig-Bing Syndrome Or Defect

Dorv

Dorv With Subpulmonary Vsd

Dorv-Tga

Double Outlet Right Ventricle With Transposition Of The Great Arteries

Double Outlet Right Ventricle With Subpulmonary Interventricular Communication, Transposition Type

Taussig-Bing Heart

Taussig-Bing Malformation

Taussig-Bing Complex

Taussig-Bing Defect

Taussig-Bing

Double Outlet Right Ventricle With Remote Ventricular Septal Defect

Double Outlet Right Ventricle With Uncommitted Ventricular Septal Defect

Double Outlet Right Ventricle With Non-Committed Interventricular Communication

Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication Without Pulmonary Stenosis

Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication And Pulmonary Stenosis

Aortic Aneurysm, Familial Thoracic 1

Thoracic Aortic Aneurysm

Annuloaortic Ectasia

Familial Thoracic Aortic Aneurysm And Aortic Dissection

Familial Aortic Dissection

Familial Taad

Congenital Aneurysm Of Ascending Aorta

Familial Aortic Aneurysm

Familial Thoracic Aortic Aneurysm

Familial Thoracic Aortic Aneurysm And Dissection

Aortic Aneurysm, Thoracic

AAT1

Faa1

Aortic Dissection, Familial

Aortic Aneurysm, Familial Thoracic

Aneurysm, Thoracic Aortic

Faa

Ftaad

Taa

Taad

Cystic Medial Necrosis Of Aorta

Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection

Aortic Aneurysm Thoracic

Familial Aortic Aneurysms

Aneurysm, Aortic, Thoracic, Familial, Type 1

Aneurysm Of Thoracic Aorta

Intrathoracic Aneurysm

Thoracic Aorta Aneurysm

Thoracic Aortic Aneurysm Without Rupture

Thoracic Aneurysm

Thorax Arterial Aneurysm

Thoracic Artery Aneurysm

Thoracic Arterial Aneurysm

Thorax Aneurysm

Thorax Aortic Aneurysm

Dissection Of Thoracic Aorta

Ehlers-Danlos Syndrome, Vascular Type

Eds Iv

Eds4

Vascular Ehlers-Danlos Syndrome

Veds

Sack-Barabas Syndrome

EDSVASC

Ehlers-Danlos Syndrome, Type Iv, Autosomal Dominant

Vascular Type Ehlers-Danlos Syndrome

Arterial-Ecchymotic Eds

Ehlers-Danlos Syndrome Type 4

Vascular Eds

Ehlers-Danlos Syndrome, Type 4

Ehlers-Danlos Syndrome, Type Iv

Ehlers-Danlos Syndrome, Arterial Type

Ehlers-Danlos Syndrome, Ecchymotic Type

Ehlers-Danlos Syndrome, Sack-Barabas Type

Autosomal Dominant Type Iv Ehlers-Danlos Syndrome

Eds Type Iv

Eds Type 4

Ehlers Danlos Syndrome, Sack-Barabas Type

Ehlers Danlos Syndrome, Arterial Type

Ehlers Danlos Syndrome, Ecchymotic Type

Ehlers-Danlos Syndrome Type Iv

Ehlers-Danlos Syndrome 4

Ehlers-Danlos Syndrome Arterial Type

Ehlers-Danlos Syndrome Ecchymotic Type

Ehlers-Danlos Syndrome, Type 4 Variant

Ehlers-Danlos, Vascular Type Syndrome

Loeys-Dietz Syndrome 3

LDS3

Aneurysms-Osteoarthritis Syndrome

Loeys-Dietz Syndrome With Osteoarthritis

Aneurysm-Osteoarthritis Syndrome

Lds1c

Loeys-Dietz Syndrome, Type 3

Loeys-Dietz Syndrome, Type 1c, Formerly

Lds1c, Formerly

Loeys-Dietz Syndrome Type 1c

Loeys-Dietz Syndrome Type 3

Aneurysm - Osteoarthritis Syndrome

Loeys-Dietz Syndrome, Type 1c

Aos

Loeys-Dietz Syndrome 1c

Breast Cyst

Cyst Of The Breast

Breast Cysts

Marfan Syndrome

MFS

Mfs1

Marfan'S Syndrome

Marfan Syndrome Type 1

Marfan Syndrome, Type I

Mass Phenotype

Contractural Arachnodactyly

Mass Syndrome

Octd

Overlap Connective Tissue Disease

Marfanoid Hypermobility Syndrome

Marfan Disease

Aortic Valve Disease 1

Aortic Valve Disease

Bicuspid Aortic Valve

Aortic Valve Disorder

AOVD1

Bav

Bicuspid Aortic Valve Disease

Familial Bicuspid Aortic Valve

Aortic Valve Calcification

Aovd

Aortic Valve, Bicuspid

Aortic Valve, Calcification Of

Aortic Stenosis, Calcific

Familial Bav

Calcific Aortic Stenosis

Calcification Of Aortic Valve

Abnormality Of The Aortic Valve

Aortic Valve Disease, Type 1

Aortic Valve Disease 2

Bicommissural Aortic Valve

Steroid-Induced Glaucoma

Corticosteroid-Induced Glaucoma

Intraocular Pressure Quantitative Trait Locus

Glaucoma

IOPQTL

Glaucoma, Susceptibility To

Postinfectious Glaucoma

Glaucoma With Ocular Inflammation

Glaucoma Secondary To Eye Inflammation

Traumatic Glaucoma

Glaucoma With Concussion Of Globe

Glaucoma Due To Ocular Trauma

Glaucoma Associated With Ocular Trauma

Glaucoma Secondary To Drugs

Upper Lip Cancer
Aortic Disease

Aortic Diseases

Aortic Disorder

Disorder Of The Aorta

Heart Disease

Heart Failure

Congenital Heart Disease

Heart Diseases

Congenital Heart Defects

Congenital Heart Defect

Congenital Anomaly Of Heart

Heart Defect

Heart Malformation

Heart-Congenital Defect

Congenital Heart Disorder

Heart Defects Congenital

Heart Defects, Congenital

Heart Defects

Heart Disease, Congenital

Disease, Heart, Congenital

Congestive Heart Failure

Neovascular Glaucoma

Glaucoma, Neovascular

Secondary Angle-Closure Glaucoma With Rubeosis

Glaucoma Neovascular

Macular Holes

Macular Hole

Open-Angle Glaucoma

Glaucoma Simplex

Pigmentary Glaucoma

Wide-Angle Glaucoma

Glaucoma, Open-Angle

Open Angle Glaucoma

Glaucoma Open-Angle

Chronic Simple Glaucoma

Coag - [Chronic Open-Angle Glaucoma]

Csg - [Chronic Simple Glaucoma]

Poag - [Primary Open-Angle Glaucoma]

Oag - [Open-Angle Glaucoma]

Chronic Glaucoma

Chronic Open Angle Glaucoma

Simple Glaucoma

Chronic Noncongestive Glaucoma

Ltg - [Low Tension Glaucoma]

Noncongestive Glaucoma

Nonobstructive Glaucoma

Normal Pressure Glaucoma

Primary Low Tension Glaucoma

Low-Tension Glaucoma

Residual Stage Low Tension Glaucoma

Open Cleft Glaucoma

Vitreous Disease

Disorder Of Vitreous Body

Scoliosis
Microvascular Complications Of Diabetes 1

Proliferative Diabetic Retinopathy

Microvascular Complications Of Diabetes, Susceptibility To, 1

MVCD1

Diabetic Nephropathy

Non-Proliferative Diabetic Retinopathy

Nonproliferative Diabetic Retinopathy

Proliferative Retinopathy, Diabetic

Proliferative Retinopathy, Diabetic, Susceptibility To

Nonproliferative Retinopathy, Diabetic

Nonproliferative Retinopathy, Diabetic, Susceptibility To

Pdr

Diabetic End-Stage Renal Disease

Diabetic Neuropathy

Diabetic Neuropathies

Complications Of Diabetes Mellitus

Diabetes Mellitus, Independent Of Type With Proliferative Retinopathy

Primary Angle-Closure Glaucoma

Primary Angle Closure Glaucoma

Angle Closure Glaucoma

Acg - [Angle Closure Glaucoma]

Angle-Closure Glaucoma

Closed Angle Glaucoma

Acute Glaucoma

Prodromal Angle Closure Glaucoma

Retinal Perforation

Retinal Break

Retinal Perforations

Retinal Dialysis

Retinal Tear

Retinal Break Nos

Ruptured Retina

Muscular Dystrophy

Muscular Dystrophies

Congenital Md

Congenital Muscular Dystrophy

Cmd

Mdc

Dystrophy, Muscular

Gower'S Muscular Dystrophy

Progressive Musclular Dystrophy

Pseudohypertrophic Atrophy

Pseudohypertrophic Muscle Paralysis

Pseudohypertrophic Muscular Atrophy

Pseudohypertrophic Muscular Dystrophy

Pseudohypertrophic Paralysis

Pseudomuscular Hypertrophy

Patent Ductus Arteriosus 1

Patent Ductus Arteriosus

PDA1

Pda

Ductus Arteriosus, Patent

Patent Ductus Arteriosus, Susceptibility To

Patent Ductus Botalli

Patency Of The Ductus Arteriosus

Patent Ductus Arteriosus Familial

Ductus Arteriosus Patent

Patent Ductus Arteriosus - Persisting Type

Malaria

Malaria, Susceptibility To

Malaria, Resistance To

Malaria, Cerebral

Cerebral Malaria

Malaria, Severe, Susceptibility To

Malaria, Severe, Resistance To

Malaria, Cerebral, Susceptibility To

Induced Malaria

Malaria, Vivax, Protection Against

Malaria, Severe

Malaria, Cerebral, Reduced Risk Of

Malaria, Protection Against

Resistance To Malaria Due To G6pd Deficiency

Malaria Due To G6pd Deficiency

Malarial Encephalitis

CM

Malaria Cerebral

Susceptibility To Malaria

Acute Pernicious Fever

Aestivo-Autumnal Fever

Aestivo Autumnal Malaria

Chagres Fever

Continued Malaria Fever

Estivo-Autumnal Fever

Estivo-Autumnal Malaria

Estivo-Autumnal Malarial Fever

Falciparum Fever

Malignant Tertian Fever

Malignant Tertian Malaria

Pernicious Intermittent Fever

Pernicious Malaria

Quotidian Malaria

Subtertian Fever

Subtertian Malaria Fever

Subtertian Malignant Tertian Malaria

Tropical Malaria

Algid Malaria

Bilious Haemoglobinuric Fever

Black Water Fever

Blackwater Fever

Malarial Blackwater Fever

Severe Malarial Falciparum

West African Fever

Malarial Haematinuria

Haemoglobinuric Fever

Haemoglobinuric Malaria

Severe Plasmodium Falciparum Malaria

Malarial Haemoglobinuria

Malarial Haematuria

Falciparum Malaria [Malignant Tertian]

Malaria Tropica

Malarial Shock

Chagres Virus Disease

Malignant Malaria

Mtm - [Malignant Tertian Malaria]

Tm -[Malignant Tertian Malaria]

Panama Fever

St - [Subtertian Malaria]

Malarial Quotidian

Benign Tertian Malaria

Tertian Ague

Vivax Fever

Plasmodium Vivax Malaria Nos

Btm - [Benign Tertian Malaria]

Bt - [Benign Tertian Malaria]

Vivax Malaria

Benign Tertian Vivax Malaria

Tertian Malaria

Quartan Malaria

Quartan Ague

Quartan Fever

Plasmodium Malariae Malaria Nos

Quartan Malarial

Malaria By Plasmodium Malariae

Malariae Malaria

Ovale Tertian Malaria

Plasmodium Ovale Fever

Malaria Fever By Plasmodium Ovale

Ovale Malaria

Malaria By Plasmodium Ovale

Malarial Ovale

Marsh Fever

Remittent Congestive Fever

Coastal Fever

Remittent Gastric Fever

Miasmatic Fever

Congestive Remittent Fever

Intermittent Fever

Jungle Fever

Paludism

Cameroon Fever

Ague

Corsican Fever

Intermittent Bilious Fever

Disease Due To Plasmodiidae

Malarial Fever

Plasmodiosis

Remittent Fever

Roman Fever

Malaria Fever Nos

Malaria Nos

Paludal Fever

Clinically Diagnosed Malaria

Clinically Diagnosed Malaria Without Parasitological Confirmation

Congestive Fever

Malarial Cachexia

Marsh Cachexia

Paludal Cachexia

Recurrent Malaria

Remittent Malaria

Camurati-Engelmann Disease

Progressive Diaphyseal Dysplasia

Ced

Engelmann Disease

Diaphyseal Dysplasia 1, Progressive

Pdd

Diaphyseal Dysplasia

Dpd1

Camurati-Engelmann Syndrome

CAEND

Engelman'S Disease

Diaphyseal Hyperostosis

Diaphyseal Osteosclerosis

Microvascular Complications Of Diabetes 5

Diabetic Retinopathy

Microvascular Complications Of Diabetes, Susceptibility To, 5

MVCD5

Retinopathy, Diabetic

Diabetic Nephropathy

Retinopathy, Diabetic, Susceptibility To

Retinal Abnormality - Diabetes-Related

Vitreous Detachment

Posterior Vitreous Detachment

Vitreous Syneresis

Corneal Disease

Corneal Diseases

Corneal Disorders

Pancreatic Cancer

Pancreatic Carcinoma

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Carcinoma Of Pancreas

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Cancer Of The Pancreas

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Hydrocephalus

Hydrocephalus, Nonsyndromic, Autosomal Recessive

Hydrocephalus, X-Linked

Hydrocephalus Adverse Event

Hydrocephaly Nos

Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma

Melanoma, Uveal

Uveal Melanoma

Choroidal Melanoma

Melanoma Of Uvea

Iris Melanoma

Malignant Melanoma Of Choroid

Malignant Melanoma Of Iris

Osteoporosis

Postmenopausal Osteoporosis

Osteoporosis, Postmenopausal

Bone Mineral Density Quantitative Trait Locus

Bmnd

Osteoporosis, Involutional

Osteoporosis, Susceptibility To

Osteoporosis, Postmenopausal, Susceptibility

Bone Mineral Density Variation Qtl, Osteoporosis

OSTEOP

Involutional Osteoporosis

Senile Osteoporosis

Osteoporosis Postmenopausal

Bone Mineral Density, Quantitative Trait Locus

Osteoporosis, Senile

Idiopathic Osteoporosis

Bone Rarefaction Nos

Type 1 Osteoporosis

Alopecia, Androgenetic, 1

Androgenetic Alopecia

Androgenic Alopecia

AGA1

Aga

Female Pattern Baldness

Male Pattern Alopecia

Male Pattern Baldness

Pattern Baldness

Alopecia, Androgenetic

Alopecia Androgenetic

Female Pattern Alopecia

Uveitis
Fuchs' Heterochromic Uveitis

Fuchs' Heterochromic Cyclitis

Fuchs Heterochromic Iridocyclitis

Fhi

Fuchs Heterochromic Cyclitis

Fuch'S Heterochromic Iridocyclitis

Fuchs Uveitis Syndrome

Fuchs Heterochromic Uveitis

Aortic Aneurysm

Aortic Rupture

Thoracoabdominal Aortic Aneurysm, Ruptured

Ruptured Aortic Aneurysm

Aortic Aneurysms

Aortic Aneurysm Without Mention Of Rupture Nos

Ruptured Abdominal Aortic Aneurysm

Aortic Aneurysm, Ruptured

Ruptured Thoracic Aortic Aneurysm

Lipoprotein Quantitative Trait Locus

Coronary Artery Disease

Coronary Artery Disease, Susceptibility To

Coronary Artery Anomaly

Myocardial Ischemia

Congenital Anomaly Of Coronary Artery

Coronary Arteriosclerosis

Coronary Disease

Coronary Heart Disease

Coronary Artery Disorder

LPAQTL

Lpa Deficiency, Congenital

Coronary Artery Abnormality

Coronary Artery Anomaly, Congenital

Chd

Coronary Syndrome

Congenital Malformations Of Coronary Vessels

Malformation Of Coronary Vessels

Congenital Coronary Artery Anomaly

Congenital Coronary Artery Deformity

Congenital Coronary Artery Disorder

Abnormal Coronary Artery

Congenital Coronary Artery Malposition

Congenital Coronary Disease

Congenital Anomaly Of Coronary Arteries

Milk Allergy

Milk Allergic Reaction

Milk Hypersensitivity

Allergy Milk

Renal Fibrosis
Loeys-Dietz Syndrome

Loeys-Dietz Aortic Aneurysm Syndrome

Lds

Aortic Aneurysm Syndrome Due To Tgf-Beta Receptors Anomalies

Furlong Syndrome

High Grade Glioma

Malignant Glioma

Glial Cell Tumor

Glioma, Malignant

Malignant Neuroglial Tumor

Neuroglial Tumor

Glioma

Malignant Gliomas

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Refractive Error

Refractive Errors

Extrinsic Allergic Alveolitis

Hypersensitivity Pneumonitis

Alveolitis

Alveolitis, Extrinsic Allergic

Allergic Interstitial Pneumonitis

Allergic Pneumonitis

Extrinsic Allergic Pneumonia Hypersensitivity Pneumonitis

Hp

Pneumonitis Hypersensitivity

Allergic Alveolitis

Extrinsic Allergic Alveolitis Nos

Airway Obstruction With Allergic Alveolitis

Unspecified Allergic Alveolitis And Pneumonitis

Extrinsic Allergic Bronchiolo-Alveolitis

Hypersensitivity Pneumonia

Hypersensitivity Pneumonitis Nos

Obstructive Lung Disease With Allergic Alveolitis

Obstructive Lung Disorder With Hypersensitivity Pneumonitis

Obstructive Lung Disorder With Allergic Alveolitis

Obstructive Lung Disease With Hypersensitivity Pneumonitis

Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Cancer Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary

Aortic Aneurysm, Familial Thoracic 4

AAT4

Faa4

Aortic Aneurysm/Aortic Dissection And Patent Ductus Arteriosus

Familial Aortic Aneurysm 4

Non-Syndromic Thoracic Aortic Aneurysms And Dissection

Taad

Thoracic Aortic Aneurysms And Dissection

Thoracic Aortic Aneurysms And Dissections

Aneurysm, Aortic, Thoracic, Familial, Type 4

Lens Disease

Lens Diseases

Hydrops Of Gallbladder

Gallbladder Hydrops

Macular Degeneration, Age-Related, 1

Macular Degeneration

Age-Related Macular Degeneration

Macular Degeneration, Age-Related

Age Related Macular Degeneration

Age Related Macular Degeneration 1

ARMD1

Maculopathy, Age-Related, 1

Macular Degeneration, Age-Related, Reduced Risk Of

Age Related Maculopathy 1

Age Related Maculopathies

Age Related Maculopathy

Senile Macular Degeneration

Senile Macular Retinal Degeneration

Macular Degeneration Of Retina

Age-Related Maculopathy

Amd

Armd

Age-Related Maculopathy, Susceptibility To

Maculopathy Age-Related

Macular Degeneration, Age-Related, 1, Susceptibility To

Maculopathy, Age-Related

Macular Degeneration, Age-Related, Type 1

Macular Degeneration, Age-Related, 2

Glioma
Eye Disease

Eye Diseases

Abnormality Of The Eye

Toxoplasma Oculopathy

Fuchs' Endothelial Dystrophy

Fuchs Endothelial Corneal Dystrophy

Fuchs Endothelial Dystrophy

Fuchs Dystrophy

Fced

Fuchs' Corneal Dystrophy

Fuchs' Endothelial Corneal Dystrophy

Fuchs Atrophy

Fuchs Corneal Dystrophy

Endoepithelial Corneal Dystrophy

Fecd

Late Hereditary Endothelial Dystrophy

Corneal Dystrophy, Fuchs Endothelial

Dystrophy, Corneal, Fuchs Endothelial

Corneal Dystrophy, Fuchs' Endothelial, 1

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus TGFB2 VGNC VGNC:107948
Bos taurus TGFB2 VGNC VGNC:35802
Rattus norvegicus TGFB2 RGD RGD:70491
Canis familiaris TGFB2 VGNC VGNC:47309
Macaca mulatta TGFB2 VGNC VGNC:78334
Mus musculus TGFB2 MGD MGI:98726
Others TGFB2 NCBI