2. Gene
  3. THBS2 - thrombospondin 2 Gene

THBS2 - thrombospondin 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TSP2

Gene ID: 7058 | Gene type: protein coding

About THBS2

Cytogenetic location: 6q27 Genomic coordinates (GRCh38): 6:169,215,785-169,253,846 (from NCBI)

This gene has 15 transcripts (splice variants), 276 orthologues, 5 paralogues and is associated with 1 phenotype. Broad expression in gall bladder (RPKM 49.1), endometrium (RPKM 31.3) and 18 other tissues.

Summary

The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration. [provided by RefSeq, Jul 2008]

THBS2 Products(5)

mRNA Protein Name
NM_001381939.1 NP_001368868.1 thrombospondin-2 isoform 2 precursor
NM_001381940.1 NP_001368869.1 thrombospondin-2 isoform 3 precursor
NM_001381941.1 NP_001368870.1 thrombospondin-2 isoform 4 precursor
NM_001381942.1 NP_001368871.1 thrombospondin-2 isoform 5
NM_003247.5 NP_003238.2 thrombospondin-2 isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
19818485 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of angiogenesis IDA
IDA: Inferred from direct assay
20714802 GOA
Cellular Component GO Annotation Evidence Reference Source
located in platelet alpha granule IDA
IDA: Inferred from direct assay
1737102 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

THBS2 Protein Structure

VWC

VWC: von Willebrand factor type C domain (320 - 374)

TSP_1

TSP_1: Thrombospondin type 1 domain (385 - 430)

TSP_1

TSP_1: Thrombospondin type 1 domain (441 - 491)

TSP_1

TSP_1: Thrombospondin type 1 domain (498 - 548)

EGF_CA

EGF_CA: Calcium-binding EGF domain (590 - 630)

EGF_3

EGF_3: EGF domain (652 - 691)

TSP_3

TSP_3: Thrombospondin type 3 repeat (729 - 764)

TSP_3

TSP_3: Thrombospondin type 3 repeat (764 - 787)

TSP_3

TSP_3: Thrombospondin type 3 repeat (789 - 823)

TSP_3

TSP_3: Thrombospondin type 3 repeat (824 - 846)

TSP_3

TSP_3: Thrombospondin type 3 repeat (847 - 884)

TSP_3

TSP_3: Thrombospondin type 3 repeat (886 - 920)

TSP_3

TSP_3: Thrombospondin type 3 repeat (921 - 952)

TSP_C

TSP_C: Thrombospondin C-terminal region (974 - 1171)

  • 0
  • 200
  • 400
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  • 800
  • 1000
  • 1172 a.a.
Protein Preferred Names Protein Names

thrombospondin-2

Related Diseases

Diseases Alias
Intervertebral Disc Disease

Lumbar Disc Disease

Intervertebral Disc Disorder

IDD

Lumbar Disc Herniation

Lumbar Disc Degeneration

Intervertebral Disc Disease, Susceptibility To

Lumbar Disc Herniation, Susceptibility To

Lumbar Disc Disease, Susceptibility To

Intervertebral Disc Degeneration

Discogenic Disease

Discogenic Disorder

Disorder Of Intervertebral Disc

Intervertebral Disk Degeneration

Intervertebral Disk Disease

Ldd

Ldh

Lumbar Disc Degeneration, Susceptibility To

Degeneration Of Lumbar Intervertebral Disc

Intervertebral Disk Displacement
Back Pain
Spinal Stenosis

Lumbar Spinal Stenosis

Cervical Spinal Stenosis

Spinal Stenosis Of Lumbar Region

Spinal Stenosis In Cervical Region

Spinal Canal Stenosis
Ehlers-Danlos Syndrome

Eds

Cutis Hyperelastica

Elastic Skin

Ehlers-Danlos Syndromes

Ed Syndrome

Ehlers Danlos Syndrome

Ehlers Danlos Disease

Eds - [Ehlers-Danlos Syndrome]
Intestinal Schistosomiasis

Schistosomiasis Japonica

Schistosomiasis Mansoni

Katayama Fever

Schistosoma Japonicum Infection

Schistosoma Mansoni Infectious Disease

Schistosomiasis
Urinary Schistosomiasis

Schistosoma Haematobium Infection

Schistosoma Hematobium Infection

Schistosomiasis Due To Schistosoma Haematobium

Bladder Schistosomiasis

Cystitis With Bilharziasis

Schistosoma Haematobium

Schistosoma Hematobium Infectious Disease

Schistosomiasis Of Bladder

Vesical Schistosomiasis

Schistosomiasis Urinary

Schistosomiasis Haematobia

Genitourinary Bilharziasis

Genitourinary Tract Schistosomiasis

Schistosomiasis Due To Schistosoma Haematobium [Urinary Schistosomiasis]

Haematochyluria In Schistosomiasis

Infection Due To Schistosoma Matthei
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Myocardial Infarction

Heart Attack

Myocardial Infarction, Susceptibility To

Myocardial Infarction 1

Myocardial Infarction, Protection Against

Myocardial Infarction, Decreased Susceptibility To

Myocardial Infarction, Decreased

Myocardial Infarct

MCI1

Premature Myocardial Infarction

Myocardial Infarction, Susceptibility To, Type 1
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14480 THBS2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus THBS2 VGNC VGNC:66155
Bos taurus THBS2 VGNC VGNC:35829
Mus musculus THBS2 MGD MGI:98738
Macaca mulatta THBS2 VGNC VGNC:104433
Canis familiaris THBS2 VGNC VGNC:47336
Rattus norvegicus THBS2 RGD RGD:1310979
Others THBS2 NCBI