2. Gene
  3. THBS3 - thrombospondin 3 Gene

THBS3 - thrombospondin 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TSP3

Gene ID: 7059 | Gene type: protein coding

About THBS3

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:155,195,588-155,209,178 (from NCBI)

This gene has 11 transcripts (splice variants), 238 orthologues and 5 paralogues. Ubiquitous expression in endometrium (RPKM 9.2), gall bladder (RPKM 7.8) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentameric molecule linked by a single disulfide bond. This gene shares a common promoter with metaxin 1. Alternate splicing results in coding and non-coding transcript variants. [provided by RefSeq, Nov 2011]

THBS3 Products(15)

mRNA Protein Name
NM_001252607.2 NP_001239536.1 thrombospondin-3 isoform 2 precursor
NM_001252608.2 NP_001239537.1 thrombospondin-3 isoform 3 precursor
NM_001407487.1 NP_001394416.1 thrombospondin-3 isoform 4 precursor
NM_001407488.1 NP_001394417.1 thrombospondin-3 isoform 5 precursor
NM_001407490.1 NP_001394419.1 thrombospondin-3 isoform 6
NM_001407554.1 NP_001394483.1 thrombospondin-3 isoform 7 precursor
NM_001407555.1 NP_001394484.1 thrombospondin-3 isoform 8 precursor
NM_001407556.1 NP_001394485.1 thrombospondin-3 isoform 9
NM_001407557.1 NP_001394486.1 thrombospondin-3 isoform 9
NM_001407558.1 NP_001394487.1 thrombospondin-3 isoform 10
NM_001407559.1 NP_001394488.1 thrombospondin-3 isoform 11
NM_001407560.1 NP_001394489.1 thrombospondin-3 isoform 12
NM_001407561.1 NP_001394490.1 thrombospondin-3 isoform 12
NM_001407562.1 NP_001394491.1 thrombospondin-3 isoform 14
NM_007112.5 NP_009043.1 thrombospondin-3 isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables heparin binding IDA
IDA: Inferred from direct assay
8288588 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
Cellular Component GO Annotation Evidence Reference Source
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
11943589 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

THBS3 Protein Structure

COMP

COMP: Cartilage oligomeric matrix protein (227 - 270)

EGF_CA

EGF_CA: Calcium-binding EGF domain (316 - 350)

EGF_CA

EGF_CA: Calcium-binding EGF domain (370 - 411)

TSP_3

TSP_3: Thrombospondin type 3 repeat (492 - 527)

TSP_3

TSP_3: Thrombospondin type 3 repeat (551 - 586)

TSP_3

TSP_3: Thrombospondin type 3 repeat (587 - 609)

TSP_3

TSP_3: Thrombospondin type 3 repeat (610 - 647)

TSP_3

TSP_3: Thrombospondin type 3 repeat (649 - 687)

TSP_3

TSP_3: Thrombospondin type 3 repeat (688 - 722)

TSP_C

TSP_C: Thrombospondin C-terminal region (741 - 941)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 956 a.a.
Protein Preferred Names Protein Names

thrombospondin-3

Related Diseases

Diseases Alias
Pseudoachondroplasia

PSACH

Pseudoachondroplastic Dysplasia

Pseudoachondroplastic Spondyloepiphyseal Dysplasia Syndrome

Spondyloepiphyseal Dysplasia, Pseudoachondroplastic

Pseudoachondroplastic Spondyloepiphyseal Dysplasia

Spondyloepiphyseal Dysplasia Pseudoachondroplastic
Gaucher'S Disease

Gaucher Disease

Kerasin Thesaurismosis

Glucocerebrosidase Deficiency

Glucosylceramidase Deficiency

Cerebroside Lipidosis Syndrome

Acid Beta-Glucosidase Deficiency

Glucosylceramide Beta-Glucosidase Deficiency

Acute Cerebral Gaucher Disease

Gaucher Splenomegaly

Glucocerebrosidosis

Glucosyl Cerebroside Lipidosis

Kerasin Lipoidosis

Lipoid Histiocytosis

Glocucerebrosidase Deficiency

Sphingolipidosis 1

Gaucher Syndrome

Gauchers Disease

Gd

Glucosylceramide Lipidosis

Kerasin Histiocytosis

Gaucher Disease, Type 1

Gaucher Disease, Type 2
Branched-Chain Keto Acid Dehydrogenase Kinase Deficiency

BCKDKD

Branched-Chain Ketoacid Dehydrogenase Kinase Deficiency

Bckdk Deficiency

Autism-Epilepsy Syndrome Due To Branched Chain Ketoacid Dehydrogenase Kinase Deficiency
Tracheal Calcification

Calcification Of Trachea
Pregnancy Adenoma

Lactating Adenoma
Multiple Epiphyseal Dysplasia

Med

Polyepiphyseal Dysplasia

Edm

Epiphyseal Dysplasia, Multiple, 1

Epiphyseal Dysplasia, Multiple, 2

Epiphyseal Dysplasia, Multiple, 3

Epiphyseal Dysplasia, Multiple, 4

Epiphyseal Dysplasia, Multiple, 5

Epiphyseal Dysplasia, Multiple

Edm1

Edm2

Edm3

Edm4

Edm5

Epiphyseal Dysplasia, Fairbank Type

Epiphyseal Dysplasia, Ribbing Type

Multiple Epiphyseal Dysplasia, Autosomal Dominant

Multiple Epiphyseal Dysplasia, Autosomal Recessive

Rmed

Dysplasia, Epiphyseal, Multiple

Osteochondrodysplasias
Alveolar Echinococcosis

Echinococcus Multilocularis Infection

Echinococcosis

Alveolococcosis

Multilocular Hydatid

Small Fox Tapeworm
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14481 THBS3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus THBS3 RGD RGD:1596780
Mus musculus THBS3 MGD MGI:98739
Macaca mulatta THBS3 VGNC VGNC:78345
Bos taurus THBS3 VGNC VGNC:35830
Canis familiaris THBS3 VGNC VGNC:47337
Felis catus THBS3 VGNC VGNC:66156