THBS3 - thrombospondin 3 Gene

Homo sapiens

Also known as TSP3

Gene ID: 7059 | Gene type: protein coding

About THBS3

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:155,195,588-155,209,178 (from NCBI)

This gene has 11 transcripts (splice variants), 238 orthologues and 5 paralogues. Ubiquitous expression in endometrium (RPKM 9.2), gall bladder (RPKM 7.8) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentameric molecule linked by a single disulfide bond. This gene shares a common promoter with metaxin 1. Alternate splicing results in coding and non-coding transcript variants. [provided by RefSeq, Nov 2011]

THBS3 Products(15)

mRNA	Protein	Name
NM_001252607.2	NP_001239536.1	thrombospondin-3 isoform 2 precursor
NM_001252608.2	NP_001239537.1	thrombospondin-3 isoform 3 precursor
NM_001407487.1	NP_001394416.1	thrombospondin-3 isoform 4 precursor
NM_001407488.1	NP_001394417.1	thrombospondin-3 isoform 5 precursor
NM_001407490.1	NP_001394419.1	thrombospondin-3 isoform 6
NM_001407554.1	NP_001394483.1	thrombospondin-3 isoform 7 precursor
NM_001407555.1	NP_001394484.1	thrombospondin-3 isoform 8 precursor
NM_001407556.1	NP_001394485.1	thrombospondin-3 isoform 9
NM_001407557.1	NP_001394486.1	thrombospondin-3 isoform 9
NM_001407558.1	NP_001394487.1	thrombospondin-3 isoform 10
NM_001407559.1	NP_001394488.1	thrombospondin-3 isoform 11
NM_001407560.1	NP_001394489.1	thrombospondin-3 isoform 12
NM_001407561.1	NP_001394490.1	thrombospondin-3 isoform 12
NM_001407562.1	NP_001394491.1	thrombospondin-3 isoform 14
NM_007112.5	NP_009043.1	thrombospondin-3 isoform 1 precursor

THBS3 Protein Structure

COMP

EGF_CA

TSP_3

TSP_C

0
200
400
600
800
956 a.a.

Protein Preferred Names

Protein Names

thrombospondin-3

Related Diseases

Diseases

Alias

Pseudoachondroplasia

PSACH	Pseudoachondroplastic Dysplasia
Pseudoachondroplastic Spondyloepiphyseal Dysplasia Syndrome	Spondyloepiphyseal Dysplasia, Pseudoachondroplastic
Pseudoachondroplastic Spondyloepiphyseal Dysplasia	Spondyloepiphyseal Dysplasia Pseudoachondroplastic

Gaucher'S Disease

Gaucher Disease	Kerasin Thesaurismosis
Glucocerebrosidase Deficiency	Glucosylceramidase Deficiency
Cerebroside Lipidosis Syndrome	Acid Beta-Glucosidase Deficiency
Glucosylceramide Beta-Glucosidase Deficiency	Acute Cerebral Gaucher Disease
Gaucher Splenomegaly	Glucocerebrosidosis
Glucosyl Cerebroside Lipidosis	Kerasin Lipoidosis
Lipoid Histiocytosis	Glocucerebrosidase Deficiency
Sphingolipidosis 1	Gaucher Syndrome
Gauchers Disease	Gd
Glucosylceramide Lipidosis	Kerasin Histiocytosis
Gaucher Disease, Type 1	Gaucher Disease, Type 2

Branched-Chain Keto Acid Dehydrogenase Kinase Deficiency

BCKDKD	Branched-Chain Ketoacid Dehydrogenase Kinase Deficiency
Bckdk Deficiency	Autism-Epilepsy Syndrome Due To Branched Chain Ketoacid Dehydrogenase Kinase Deficiency

Tracheal Calcification

Calcification Of Trachea

Pregnancy Adenoma

Lactating Adenoma

Multiple Epiphyseal Dysplasia

Med	Polyepiphyseal Dysplasia
Edm	Epiphyseal Dysplasia, Multiple, 1
Epiphyseal Dysplasia, Multiple, 2	Epiphyseal Dysplasia, Multiple, 3
Epiphyseal Dysplasia, Multiple, 4	Epiphyseal Dysplasia, Multiple, 5
Epiphyseal Dysplasia, Multiple	Edm1
Edm2	Edm3
Edm4	Edm5
Epiphyseal Dysplasia, Fairbank Type	Epiphyseal Dysplasia, Ribbing Type
Multiple Epiphyseal Dysplasia, Autosomal Dominant	Multiple Epiphyseal Dysplasia, Autosomal Recessive
Rmed	Dysplasia, Epiphyseal, Multiple
Osteochondrodysplasias

Alveolar Echinococcosis

Echinococcus Multilocularis Infection	Echinococcosis
Alveolococcosis	Multilocular Hydatid
Small Fox Tapeworm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14481	THBS3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	THBS3	RGD	RGD:1596780
Mus musculus	THBS3	MGD	MGI:98739
Macaca mulatta	THBS3	VGNC	VGNC:78345
Bos taurus	THBS3	VGNC	VGNC:35830
Canis familiaris	THBS3	VGNC	VGNC:47337
Felis catus	THBS3	VGNC	VGNC:66156

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