TLN1 - talin 1 Gene

Homo sapiens

Also known as TLN; ILWEQ; talin-1

Gene ID: 7094 | Gene type: protein coding

About TLN1

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:35,696,948-35,732,195 (from NCBI)

This gene has 8 transcripts (splice variants), 209 orthologues and 2 paralogues. Ubiquitous expression in fat (RPKM 74.7), spleen (RPKM 60.6) and 25 other tissues.

Summary

This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. [provided by RefSeq, Feb 2009]

TLN1 Products(1)

mRNA	Protein	Name
NM_006289.4	NP_006280.3	talin-1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables LIM domain binding	IPI IPI: Inferred from physical interaction	10320340	GOA
enables integrin binding	IPI IPI: Inferred from physical interaction	12473654	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11279249	GOA
enables vinculin binding	IPI IPI: Inferred from physical interaction	15070891	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in adherens junction	IMP IMP: Inferred from mutant phenotype	26923917	GOA
located in focal adhesion	IDA IDA: Inferred from direct assay	15070891	GOA
located in focal adhesion	IMP IMP: Inferred from mutant phenotype	26923917	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TLN1 Protein Structure

FERM_N

FERM_M

IRS

Talin_middle

VBS

I_LWEQ

0
400
800
1200
1600
2000
2400
2541 a.a.

Protein Preferred Names

Protein Names

talin-1

Related Diseases

Diseases

Alias

Capillary Leak Syndrome

Systemic Capillary Leak Syndrome	Clarkson Disease
Capillary Leak Syndrome With Monoclonal Gammopathy	Scls
Periodic Systemic Capillary Leak Syndrome	Capillary Hyperpermeability Syndrome
Idiopathic Capillary Leak Syndrome

Adenomyosis

Endometriosis Of Uterus	Endometriosis Interna
Endometriosis Of Myometrium	Endometriosis, Myometrium
Uterine Adenomyosis	Adenomyosis Uteri
Internal Endometriosis

Leukocyte Adhesion Deficiency, Type I

Leukocyte Adhesion Deficiency	Leukocyte Adhesion Deficiency 1
LAD1	Lad
Lymphocyte Function-Associated Antigen 1 Immunodeficiency	Leukocyte Adhesion Deficiency Type I
Leukocyte Adhesion Deficiency Type 1	Linear Iga Bullous Dermatosis
Linear Iga Dermatosis	Leukocyte-Adhesion Deficiency Syndrome
Lfa1 Immunodeficiency	Congenital Leukocyte Adherence Deficiency
Lad-I	Linear Iga Disease
Leukocyte Adhesion Deficiency Syndrome	Lad 1
Lfa 1 Immunodeficiency	Linear Immunoglobulin A Dermatosis
Leucocyte Adhesion Deficiency Type 1	Leukocyte Adhesion Molecule Deficiency Type 1

Leukocyte Adhesion Deficiency, Type Iii

Leukocyte Adhesion Deficiency 3	LAD3
Leukocyte Adhesion Deficiency 1 Variant	Lad1v
Integrin Activation Deficiency Disease	Iadd
Leukocyte Adhesion Deficiency Type Iii	Lad1 Variant
Lad-1 Variant	Lad-Iii
Leukocyte Adhesion Deficiency-1 Variant	Leukocyte Adhesion Deficiency Type 1

Focal Segmental Glomerulosclerosis

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome	Focal Glomerulosclerosis
Fsgs	Segmental Glomerulosclerosis
Glomerulosclerosis, Focal Segmental	Fgs
Focal Glomerular Sclerosis	Familial Idiopathic Nephrotic Syndrome
Focal Sclerosis With Hyalinosis	Glomerulosclerosis, Focal
Glomerulosclerosis Focal	Glomerulosclerosis, Segmental, Focal
Focal Segmental Glomerulosclerosis, Not Otherwise Specified

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency	Congenital Combined Immunodeficiency
Syndrome With Combined Immunodeficiency	Combined T And B Cell Immunodeficiency
Combined Immunity Deficiency	Combined Immunodeficiency Syndrome
Combined T-Cell And B-Cell Immunodeficiency	Lymphopenic Agammaglobulinaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14574	TLN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TLN1	VGNC	VGNC:35897
Canis familiaris	TLN1	VGNC	VGNC:47401
Felis catus	TLN1	VGNC	VGNC:66215
Mus musculus	TLN1	MGD	MGI:1099832
Macaca mulatta	TLN1	VGNC	VGNC:78371
Rattus norvegicus	TLN1	RGD	RGD:1306247
Others	TLN1	NCBI

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