TLR5 - toll like receptor 5 Gene

Homo sapiens

Also known as SLE1; TIL3; SLEB1; MELIOS

Gene ID: 7100 | Gene type: protein coding

About TLR5

Cytogenetic location: 1q41 Genomic coordinates (GRCh38): 1:223,109,404-223,143,248 (from NCBI)

This gene has 8 transcripts (splice variants), 183 orthologues, 22 paralogues and is associated with 3 phenotypes. Ubiquitous expression in ovary (RPKM 7.6), lung (RPKM 2.6) and 22 other tissues.

Summary

This gene encodes a member of the Toll-like Receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes Bacterial flagellin, the principal component of Bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009]

TLR5 Products(1)

mRNA	Protein	Name
NM_003268.6	NP_003259.2	toll-like receptor 5 precursor

TLR5 Protein Structure

LRR_8

LRR_1

LRR_8

TIR

0
200
400
600
800
858 a.a.

Protein Preferred Names

Protein Names

toll-like receptor 5

systemic lupus erythematosus susceptibility 1

Related Diseases

Diseases

Alias

Legionnaire Disease

Legionnaires' Disease	Legionnaires Disease
Legionnaire Disease, Susceptibility To	Legionella
Legionella Pneumonia	Infection By Legionella Pneumophilia
Legionnaire'S Disease	Legionellosis
Legionaire Disease, Susceptibility To	Legionnaires Pneumonia

Melioidosis

Melioidosis, Susceptibility To	Acute And Fulminating Melioidosis
Nightcliff Gardener'S Disease	Pseudoglanders
Subacute And Chronic Melioidosis	Burkholderia Pseudomallei Infection
Whitmore Disease	Whitmore'S Disease
B Pseudomallei Infection	Epizootic Lymphangitis
Infection Due To Burkholderia Pseudomallei	Infection Due To Burkholderia Pseudomallei Nos
Infection Due To Malleomyces Pseudomallei	Infection Due To Pseudomonas Pseudomallei
Infection Due To Pseudomonas Pseudomallei Nos	Infection Due To Whitmore Bacillus
Stanton Disease

Systemic Lupus Erythematosus 1

SLEB1	Systemic Lupus Erythematosus, Susceptibility To, 1
Systemic Lupus Erythematosus, Resistance To	Systemic Lupus Erythematosus
Lupus Erythematosus, Systemic, Type 1	Lupus Erythematosus, Systemic

Lupus Erythematosus

Lupus	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus, Systemic
Subacute Cutaneous Lupus	Le - [Lupus Erythematosus]

Typhoid Fever

Typhoid	Enteric Fever
Typhoidal Salmonellosis	Ileotyphus
Infection By Salmonella Typhi	Typhoid Any Site
Typhoid Fever Any Site	Typhoid Infection
Typhoid Infection Any Site	Typhoid Fever Confirmed
Enteric Fever Nos

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Bacteriuria

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Ileitis

Crohn'S Ileitis

Legionellosis

Legionella Infection	Pontiac Fever
Legionnaires' Disease	Infection By Legionella Pneumophilia
Legionella Pneumophila Infection

Colitis

Toxoplasmosis

Disseminated Toxoplasmosis	Multisystemic Disseminated Toxoplasmosis
Acquired Toxoplasmosis	Toxoplasmosis Disease Or Disorder
Infection By Toxoplasma Gondii	Toxoplasmal
Toxoplasma

Aspergillosis

Aspergillosis, Susceptibility To	Infection Due To Aspergillus
Aspergilloma	Aspergillus Nodule
Simple Aspergilloma	Aspergillus
Aspergillus Flavus Infection	Aspergillus Fumigatus Infection
Aspergillus Infection	Infection By Aspergillus Fumigatus
Intracavitary Aspergillus Fungus Ball	Aspergillus Terreus

Bacterial Infectious Disease

Bacterial Infections	Bacterial Infection Nos
Disease Caused By Bacteria	Bacterial Disease Or Disorder

Salmonellosis

Salmonella Infections

Salmonella Infection

Otitis Media

Opsoclonus-Myoclonus Syndrome	OMS
Otitis Media, Susceptibility To	Kinsbourne Syndrome
Otitis Media, Chronic/Recurrent	Come/Rom
Ataxo-Opso-Myoclonus Syndrome	Dancing Eye Syndrome
Dancing Eye-Dancing Feet Syndrome	Oma Syndrome
Opsoclonus Myoclonus Syndrome	Opsoclonus-Myoclonus-Ataxia Syndrome
Poma Syndrome	Paraneoplastic Opsoclonus-Myoclonus
Paraneoplastic Opsoclonus-Myoclonus-Ataxia Syndrome	Opsoclonus Myoclonus
OM	{Otitis Media, Susceptibility To}
Infectious Otitis Media

Superficial Basal Cell Carcinoma

Multifocal Superficial Basal Cell Carcinoma	Multicentric Basal Cell Carcinoma
Superficial Multicentric Basal-Cell Carcinoma

Von Willebrand Disease, Type 3

Von Willebrand Disease Type 3	VWD3
Von Willebrand'S Disease 3	Von Willebrand Disease Type Iii
Von Willebrand Disease, Type Iii	Vwd, Type 3
Vwd Type 3	Von Willebrand Disease 3
Von Willebrand Disease Recessive Form	Von Willebrand Factor Deficiency Type 3

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Chromosome 17q23.1-Q23.2 Deletion Syndrome

17q23.1q23.2 Microdeletion Syndrome	17q23.1-Q23.2 Microdeletion Syndrome
Del(17)(Q23.1q23.2)	Monosomy 17q23.1q23.2
Monosomy 17q23.1-Q23.2

Narcolepsy

Paroxysmal Sleep	Gelineau Syndrome
Narcoleptic Syndrome	Narcolepsy-Cataplexy Syndrome
Cataplexy And Narcolepsy	Narcolepsy, Without Cataplexy
Gelineau'S Syndrome	Narcolepsy With Or Without Cataplexy
Narcolepsy Nos

Pneumonic Tularemia

Pulmonary Tularemia	Bronchopneumonic Tularemia
Pneumonic Tularaemia

Glanders

Farcy Pipes	Infection Due To Pseudomonas Mallei
Burkholderia Mallei	Burkholderia Mallei Infection
Equina	Equine Glanders
Farcy	Farcy Buds
Farcy Cords	Infection Due To Actinobacillus Mallei
Infection Due To Malleomyces Mallei	Maliasmus
Malleus	Farce
Actinobacillosis	Actinobacillus Infection

Primary Bacterial Infectious Disease

Anogenital Venereal Wart

Genital Warts	Condylomata Acuminata
Anogenital Warts	Condyloma Acuminatum
Anogenital Human Papilloma Virus Infectious Disease	Genital Wart Virus Infectious Disease
Venereal Wart	Venereal Warts
Verrucae Anogenitales	Verrucae Genitales

Blood Group, Globoside System

Globe Disease	GLOB
Blood Group System, Globoside

Perinatal Necrotizing Enterocolitis

Necrotizing Enterocolitis	Enterocolitis Necrotizing
Enterocolitis, Necrotizing	Necrotizing Enterocolitis In Fetus Or Newborn
Perinatal Necrotising Enterocolitis	Pseudomembranous Enterocolitis In Newborn
Nec

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Plague

Yersiniosis	Yersinia Infections
Infection By Yersinia Pestis	Pasteurella Pestis Infection
Pestilential Fever	Yersinia Pestis Infection

Cataract 9, Multiple Types

Cataract 9 Multiple Types	CTRCT9
Cataract, Autosomal Dominant	Catc1
Cataract 9, Multiple Types, With Or Without Microcornea	Cataract, Autosomal Recessive Congenital 1
Autosomal Recessive Congenital Cataract 1	Cataract 9 Multiple Types With Or Without Microcornea
Autosomal Dominant Congenital Cataract	Cataract Autosomal Dominant
Cataracts, Autosomal Dominant

Ankylosing Spondylitis 1

Ankylosing Spondylitis, Susceptibility To, 1

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Heart Malformation
Congenital Anomaly Of Heart	Heart Defect
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Crohn'S Disease

Crohn Disease	Pediatric Crohn'S Disease
Regional Enteritis	Crohn'S Disease Of Large Bowel
Granulomatous Colitis	Enteritis, Granulomatous
Enteritis	Crohn'S Disease Of Colon
Colitis, Granulomatous	Crohn'S Enteritis
Enteritis, Regional	Ileitis
Adenoviral Enteritis	Acute Gastroenteropathy Due To Norwalk Agent
Viral Gastroenteritis Due To Norwalk Agent	Winter Vomiting
Epidemic Winter Vomiting Disease	Small Round Structured Virus Enteritis
Epidemic Vomiting Syndrome	Epidemic Vomiting
Epidemic Nausea	Epidemic Viral Gastroenteritis Due To Norwalk Virus
Noroviral Enteritis	Crohn Disease Nos
Crohns	Cd - [Crohn'S Disease]
Regional Enteritis Of Bowel	Crohn'S Regional Enteritis
Cobble-Stone Appearance Of Intestine	Intestinal Ulcer And Erosion Due To Crohn Disease
Granulomatous Enteritis

Celiac Disease 1

Celiac Disease	Coeliac Disease
Celiac Sprue	Celiac Disease, Susceptibility To
Gluten-Sensitive Enteropathy	Nontropical Sprue
Sprue	CELIAC1
Celiac Disease, Susceptibility To, 1	Celiac Sprue 1
Celiac Sprue, Susceptibility To, 1	Gluten-Sensitive Enteropathy 1
Gluten-Sensitive Enteropathy, Susceptibility To, 1	Idiopathic Steatorrhea
Cœliac Disease	Gluten Intolerance
Gluten-Induced Enteropathy	Gluten Enteropathy
Celiac Disease, Susceptibility To, Type 1	Childhood Celiac Disease
Coeliac Rickets	Gee Disease
Gee-Herter Disease	Heubner-Herter Disease
Idiopathic Steatorrhoea	Thaysen'S Disease
Herter Gee Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-116961	TH1020		99.60%	Unkown
HY-NP134	Flagellin from S. typhimurium	Agonist	/	Unkown
HY-RS14589	TLR5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TLR5	RGD	RGD:631351
Bos taurus	TLR5	VGNC	VGNC:52835
Mus musculus	TLR5	MGD	MGI:1858171
Macaca mulatta	TLR5	VGNC	VGNC:78376
Felis catus	TLR5	VGNC	VGNC:107950