C1QC - complement C1q C chain Gene

Homo sapiens

Also known as C1QG; C1Q-C

Gene ID: 714 | Gene type: protein coding

About C1QC

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:22,643,633-22,648,108 (from NCBI)

This gene has 8 transcripts (splice variants), 168 orthologues, 23 paralogues and is associated with 2 phenotypes. Broad expression in spleen (RPKM 519.1), lymph node (RPKM 141.4) and 14 other tissues.

Summary

This gene encodes the C-chain polypeptide of serum complement subcomponent C1q, which associates with C1r and C1s to yield the first component of the serum Complement System. C1q is composed of 18 polypeptide chains which include 6 A-chains, 6 B-chains, and 6 C-chains. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. C1q deficiency is associated with lupus erythematosus and glomerulonephritis. [provided by RefSeq, Dec 2016]

C1QC Products(4)

mRNA	Protein	Name
NM_001114101.3	NP_001107573.1	complement C1q subcomponent subunit C isoform 1 precursor
NM_001347619.2	NP_001334548.1	complement C1q subcomponent subunit C isoform 1 precursor
NM_001347620.2	NP_001334549.1	complement C1q subcomponent subunit C isoform 2
NM_172369.5	NP_758957.2	complement C1q subcomponent subunit C isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28018340	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in complement activation, classical pathway	IDA IDA: Inferred from direct assay	29449492	GOA
involved in negative regulation of granulocyte differentiation	IDA IDA: Inferred from direct assay	10961870	GOA
involved in negative regulation of macrophage differentiation	IDA IDA: Inferred from direct assay	10961870	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of complement component C1q complex	IPI IPI: Inferred from physical interaction	29449492	GOA
located in extracellular region	IDA IDA: Inferred from direct assay	18250442	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

C1QC Protein Structure

Collagen

C1q

0
100
200
245 a.a.

Protein Preferred Names

Protein Names

complement C1q subcomponent subunit C

complement component 1, q subcomponent, C chain

Related Diseases

Diseases

Alias

C1q Deficiency

C1QD	Complement Component C1q Deficiency

Immunodeficiency Due To A Classical Component Pathway Complement Deficiency

Immunodeficiency Due To C1, C4, Or C2 Component Complement Deficiency

Immunodeficiency Due To An Early Component Of Complement Deficiency

Glomerulonephritis

Bright'S Disease

Lupus Erythematosus

Lupus	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus, Systemic
Subacute Cutaneous Lupus	Le - [Lupus Erythematosus]

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Angioedema, Hereditary, 1

Hereditary Angioedema Type I	Hereditary Angioneurotic Edema
Hane	C1 Esterase Inhibitor Deficiency
Angioedema, Hereditary, 1 And 2	HAE1
Angioneurotic Edema, Hereditary	Angioedema, Hereditary, Type I
Hereditary Angioedema Type 2	Hae 2
Hae-Ii	Hereditary Angioneurotic Edema Type 2
Angioedema, Hereditary	HAE
Angioedema, Hereditary, Types I And Ii	Hereditary Angioedema, Type Ii
Angioedema, Hereditary, Type 1	Angioedemas, Hereditary
Hereditary C1 Esterase Inhibitor Deficiency - Dysfunctional Factor	Hereditary C1 Esterase Inhibitor Deficiency - Deficient Factor
Hereditary Angioedema Types I And Ii

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01721	C1QC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	C1QC	VGNC	VGNC:52112
Bos taurus	C1QC	VGNC	VGNC:26619
Macaca mulatta	C1QC	VGNC	VGNC:99857
Rattus norvegicus	C1QC	RGD	RGD:1306828
Mus musculus	C1QC	MGD	MGI:88225
Felis catus	C1QC	VGNC	VGNC:107491

Name
Email *

	Sorry, but the email address you supplied was invalid.