2. Gene
  3. TPM4 - tropomyosin 4 Gene

TPM4 - tropomyosin 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HEL-S-108

Gene ID: 7171 | Gene type: protein coding

About TPM4

Cytogenetic location: 19p13.12-p13.11 Genomic coordinates (GRCh38): 19:16,067,538-16,103,002 (from NCBI)

This gene has 35 transcripts (splice variants), 258 orthologues, 3 paralogues and is associated with 54 phenotypes. Ubiquitous expression in gall bladder (RPKM 102.4), urinary bladder (RPKM 100.5) and 25 other tissues.

Summary

This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the Cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of Myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]

TPM4 Products(5)

mRNA Protein Name
NM_001145160.2 NP_001138632.1 tropomyosin alpha-4 chain isoform Tpm4.1cy
NM_001367836.1 NP_001354765.1 tropomyosin alpha-4 chain isoform 3
NM_001367837.2 NP_001354766.1 tropomyosin alpha-4 chain isoform 4
NM_001367838.1 NP_001354767.1 tropomyosin alpha-4 chain isoform 5
NM_003290.3 NP_003281.1 tropomyosin alpha-4 chain isoform Tpm4.2cy
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
24407287 GOA
Biological Process GO Annotation Evidence Reference Source
involved in platelet formation IMP
IMP: Inferred from mutant phenotype
28134622 GOA
Cellular Component GO Annotation Evidence Reference Source
located in stress fiber IDA
IDA: Inferred from direct assay
16236705 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TPM4 Protein Structure

Tropomyosin

Tropomyosin: Tropomyosin (12 - 247)

  • 0
  • 100
  • 200
  • 248 a.a.
Protein Preferred Names Protein Names

tropomyosin alpha-4 chain

TM30p1

Recombinant TPM4 Proteins

Cat. No. Product Name Accession Purity
HY-P76111 TPM4 Protein, Human (HEK293, His) P67936 (A2-I248) ≥95%

Related Diseases

Diseases Alias
Inflammatory Myofibroblastic Tumor

Inflammatory Fibrosarcoma
Autosomal Dominant Macrothrombocytopenia
Epithelioid Inflammatory Myofibroblastic Sarcoma
Arthrogryposis, Distal, Type 1a

Distal Arthrogryposis Type 1

Digitotalar Dysmorphism

DA1A

Da1

Amcd1

Arthrogryposis, Distal, Type 2b4

Distal Arthrogryposis Type 1a

Arthrogryposis, Distal, Type 1

Arthrogryposis Multiplex Congenita Distal Type 1

Arthrogryposis Multiplex Congenita, Distal Type 1

Arthrogryposis Multiplex Congenita, Distal, Type I

Distal Arthrogryposis Type 1b

Arthrogryposis, Distal, 1a

Amc

Arthrogryposis Multiplex Congenita

Arthrogryposis, Distal, 2b4

DA2B4

Arthrogryposis Multiplex Congenita, Distal, Type 1

Arthrogryposis
Mesenchymal Cell Neoplasm

Benign Miscellaneous Mesenchymal Tumor

Mesenchymal Tumor

Mesenchymal Tumors
Pseudosarcomatous Fibromatosis

Nodular Fasciitis

Pseudosarcomatous Fasciitis

Fasciitis - Nodular

Fasciitis Nodular
Cardiomyopathy, Familial Hypertrophic, 1

Asymmetric Septal Hypertrophy

Familial Hypertrophic Cardiomyopathy

Hypertrophic Cardiomyopathy 1

CMH1

Hypertrophic Cardiomyopathy 19

CMH

Ventricular Hypertrophy, Hereditary

Ash

Hypertrophic Subaortic Stenosis, Idiopathic

Cardiomyopathy, Familial Hypertrophic

Cardiomyopathy, Hypertrophic, 1, Digenic

Cardiomyopathy, Familial Hypertrophic 1

Hcm

Hereditary Ventricular Hypertrophy

Idiopathic Hypertrophic Subaortic Stenosis

Hypertrophic Cardiomyopathy

Cardiomyopathy, Hypertrophic, Familial

Cardiomyopathy, Hypertrophic, 1

Familial Asymmetric Septal Hypertrophy

Heritable Hypertrophic Cardiomyopathy

Fhc

Cardiomyopathy, Hypertrophic, Familial, Type 1
Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy

Cardiomyopathy, Hypertrophic

Cardiomyopathy Hypertrophic Obstructive

Cardiomyopathy, Hypertrophic, Familial

Idiopathic Myocardial Hypertrophy

Idiopathic Hypertrophic Cardiomyopathy

Obstructive Idiopathic Hypertrophic Cardiomyopathy

Obstructive Cardiomyopathy

Idiopathic Hypertrophic Subaortic Stenosis

Muscular Subaortic Stenosis

Hypertrophic Obstructive Subaortic Stenosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-108440 Shz-1 99.88% Unkown
HY-RS14939 TPM4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TPM4 VGNC VGNC:66478
Rattus norvegicus TPM4 RGD RGD:3899
Canis familiaris TPM4 VGNC VGNC:47744
Bos taurus TPM4 VGNC VGNC:36254
Mus musculus TPM4 MGD MGI:2449202
Others TPM4 NCBI