TRPC1 - transient receptor potential cation channel subfamily C member 1 Gene

Homo sapiens

Also known as TRP1; HTRP-1

Gene ID: 7220 | Gene type: protein coding

About TRPC1

Cytogenetic location: 3q23 Genomic coordinates (GRCh38): 3:142,724,034-142,807,888 (from NCBI)

This gene has 5 transcripts (splice variants), 201 orthologues and 5 paralogues. Ubiquitous expression in ovary (RPKM 4.8), endometrium (RPKM 3.9) and 22 other tissues.

Summary

The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and Other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

TRPC1 Products(17)

mRNA	Protein	Name
NM_001251845.2	NP_001238774.1	short transient receptor potential channel 1 isoform 1
NM_001413361.1	NP_001400290.1	short transient receptor potential channel 1 isoform 3
NM_001413362.1	NP_001400291.1	short transient receptor potential channel 1 isoform 4
NM_001413363.1	NP_001400292.1	short transient receptor potential channel 1 isoform 5
NM_001413375.1	NP_001400304.1	short transient receptor potential channel 1 isoform 7
NM_001413376.1	NP_001400305.1	short transient receptor potential channel 1 isoform 6
NM_001413377.1	NP_001400306.1	short transient receptor potential channel 1 isoform 8
NM_001413378.1	NP_001400307.1	short transient receptor potential channel 1 isoform 9
NM_001413379.1	NP_001400308.1	short transient receptor potential channel 1 isoform 10
NM_001413380.1	NP_001400309.1	short transient receptor potential channel 1 isoform 11
NM_001413381.1	NP_001400310.1	short transient receptor potential channel 1 isoform 12
NM_001413382.1	NP_001400311.1	short transient receptor potential channel 1 isoform 13
NM_001413383.1	NP_001400312.1	short transient receptor potential channel 1 isoform 14
NM_001413384.1	NP_001400313.1	short transient receptor potential channel 1 isoform 15
NM_001413385.1	NP_001400314.1	short transient receptor potential channel 1 isoform 16
NM_001413386.1	NP_001400315.1	short transient receptor potential channel 1 isoform 17
NM_003304.5	NP_003295.1	short transient receptor potential channel 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATPase binding	IPI IPI: Inferred from physical interaction	18068335	GOA
enables inositol 1,4,5 trisphosphate binding	IDA IDA: Inferred from direct assay	14505576	GOA
enables monoatomic cation channel activity	EXP EXP: Inferred from Experiment	18995841	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10097141	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	18068335	GOA
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	10097141	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in melanin biosynthetic process	IDA IDA: Inferred from direct assay	8126111	GOA
involved in positive regulation of release of sequestered calcium ion into cytosol	IDA IDA: Inferred from direct assay	19052258	GOA
involved in regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	19052258	GOA
involved in response to calcium ion	IDA IDA: Inferred from direct assay	14505576	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	14505576	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRPC1 Protein Structure

Ank_2

TRP_2

Ion_trans

0
200
400
600
793 a.a.

Protein Preferred Names

Protein Names

short transient receptor potential channel 1

capacitative calcium channel protein Trp1

TRPC1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TRPC1	P48995	STIM1	Homo sapiens	Q13586	Anti Bait CoIP	21408196
Intra	TRPC1	P48995	STIM1	Homo sapiens	Q13586	Anti Bait CoIP	19897728
Intra	TRPC1	P48995	CAV1	Homo sapiens	Q03135	Anti Bait CoIP	19897728
Intra	TRPC1	P48995	CAV1	Homo sapiens	Q03135	FRET	19897728
Intra	TRPC1	P48995	CAV1	Homo sapiens	Q03135	Y2H	19897728
Cross	TRPC1	P48995	Trpv4	Mus musculus	Q9EPK8	Anti Bait CoIP	25114176
Intra	TRPC1	P48995	PKD2	Homo sapiens	Q13563	Confocal	10097141
Intra	TRPC1	P48995	PKD2	Homo sapiens	Q13563	Anti Bait CoIP	25114176
Intra	TRPC1	P48995	PKD2	Homo sapiens	Q13563	Anti Tag CoIP	10097141

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Pyloric Stenosis

Immunodeficiency 10

Immune Dysfunction With T-Cell Inactivation Due To Calcium Entry Defect 2	Combined Immunodeficiency Due To Stim1 Deficiency
IMD10	Stim1 Deficiency
Cid Due To Stim1 Deficiency	Immune Dysfunction, With T-Cell Inactivation Due To Calcium Entry Defect 2
Immunodeficiency, Type 10

T Cell And Nk Cell Immunodeficiency

Lymph Node Carcinoma

Lymph Node Cancer	Lymph Node Neoplasm
Neoplasm Of Lymph Node

Darier-White Disease

Keratosis Follicularis	Darier Disease
Darier'S Disease	DAR
DD	Darier White Disease
Darier Disease Acral Hemorrhagic Type	Darier Disease Segmental
Darier Disease, Acral Hemorrhagic Type	Darier Disease, Segmental

Mucolipidosis Iv

Mucolipidosis Type Iv	ML4
Sialolipidosis	Mucolipidosis Type 4
Ganglioside Sialidase Deficiency	Mliv
Ml Iv	Berman Syndrome
Ganglioside Neuraminidase Deficiency	Ml 4
Mucolipidosis 4	Type Iv Mucolipidosis
Gangliosidoses

Spondyloepiphyseal Dysplasia, Maroteaux Type

Spondyloepiphyseal Dysplasia Maroteaux Type	Pseudo-Morquio Syndrome Type 2
Sed, Maroteaux Type	Brachyolmia Type 2
Pseudo-Morquio Syndrome, Type 2	Spondyloepiphyseal Dysplasia Of Maroteaux
Brachyolmia Maroteaux Type	SEDM
Sed Maroteaux Type	Dysplasia, Spondyloepiphyseal, Maroteaux Type

Brachyolmia

Brachyrachia

Stormorken Syndrome

Thrombocytopathy, Asplenia, And Miosis	Stormorken-Sjaastad-Langslet Syndrome
STRMK	York Platelet Syndrome
Yps	Thrombocytopathy, Asplenia And Miosis
Thrombocytopathy Asplenia Miosis	Thrombocytopathy-Asplenia-Miosis Syndrome
Miosis Disorder

Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques

Olmsted Syndrome	Mutilating Palmoplantar Hyperkeratosis With Periorificial Keratotic Plaques
Palmoplantar And Periorificial Keratoderma	Olms

Orthostatic Intolerance

Mitral Valve Prolapse	Neurocirculatory Asthenia
Mitral Valve Prolapse Syndrome	Irritable Heart
Systolic Click-Murmur Syndrome	Soldiers Heart
Cardiovascular Malfunction Arising From Mental Factors	Cardiovascular Neurosis
Da Costa'S Syndrome	Krishaber'S Disease
Barlow'S Syndrome	Floppy Mitral Valve
Mitral Leaflet Syndrome	Myxomatous Mitral Valve Prolapse
Postural Orthostatic Tachycardia Syndrome Due To Net Deficiency	Familial Orthostatic Tachycardia Due To Norepinephrine Transporter Deficiency
Orthostatic Intolerance Due To Net Deficiency	Pots Due To Net Deficiency
OI	Intolerance, Orthostatic
Mitral Valve Prolapse, Familial, X-Linked	Ballooning Mitral Valve
Barlow Syndrome	Flail Mitral Leaflet
Myxomatous Mitral Valve	Mitral Valve Prolapse-Click Syndrome
Prolapsing Mitral Valve Leaflet Syndrome	Billowing Mitral Valve Leaflet
Posterior Mitral Leaflet Deformity	Ballooning Posterior Leaflet Syndrome
Blue Valve Syndrome	Floppy Mitral Valve Syndrome
Mitral Valvular Prolapse	Systolic Click Syndrome

Autosomal Dominant Polycystic Kidney Disease

Polycystic Kidney Disease, Adult Type	Adpkd
Polycystic Kidney Diseases	Polycystic Kidney, Autosomal Dominant
Congenital Biliary Ectasias	Polycystic Kidney And Hepatic Disease 1
Polycystic Kidney Disease, Autosomal Dominant	Kidney, Polycystic, Disease, Autosomal Dominant
Adult Polycystic Kidney Disease	Polycystic Kidney, Adult Type
Apckd - [Autosomal Polycystic Kidney Disease]

Polycystic Kidney Disease 1 With Or Without Polycystic Liver Disease

Polycystic Kidney Disease 1	PKD1
Adpkd	Polycystic Kidney Disease, Adult, Type I
Apkd1	Potter Type Iii Polycystic Kidney Disease
Polycystic Kidney Disease, Adult	Potter Type Iii Polycystic Kidney Disease, Formerly
Polycystic Kidney Disease, Type 1	Adpkd1
Adult Polycystic Kidney Disease Type 1	Autosomal Dominant Polycystic Kidney Disease 1
Pkd-1	Polycystic Kidney Disease Adult
Polycystic Kidney Disease Type I	Polycystic Kidneys
Polycystic Kidney Disease, Adult Type I	Polycystic Kidney Type 1 Autosomal Dominant Disease
Kidney Disease, Polycystic, Type 1	Polycystic Kidney, Autosomal Dominant
Polycystic Kidney, Type 1 Autosomal Dominant Disease	Polycystic Kidney Diseases

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Polycystic Kidney Disease

Polycystic Kidney Diseases	Pkd
Polycystic Renal Disease	Kidney Disease, Polycystic
Polycystic Kidney, Autosomal Dominant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101507	Zerencotrep	Inhibitor	99.40%	Unkown
HY-138868	17-Phenyl trinor prostaglandin E2 ethyl amide	Agonist	/	Unkown
HY-RS15104	TRPC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TRPC1	RGD	RGD:619783
Bos taurus	TRPC1	VGNC	VGNC:36381
Canis familiaris	TRPC1	VGNC	VGNC:47866
Mus musculus	TRPC1	MGD	MGI:109528
Macaca mulatta	TRPC1	VGNC	VGNC:78651
Felis catus	TRPC1	VGNC	VGNC:66581

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