GFUS - GDP-L-fucose synthase Gene

Homo sapiens

Also known as FX; P35B; TSTA3; SDR4E1

Gene ID: 7264 | Gene type: protein coding

About GFUS

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:143,612,618-143,618,048 (from NCBI)

This gene has 16 transcripts (splice variants), 1 gene allele, 277 orthologues and 10 paralogues. Ubiquitous expression in stomach (RPKM 48.7), skin (RPKM 31.8) and 25 other tissues.

Summary

Tissue specific transplantation antigen P35B is a NADP(H)-binding protein. It catalyze the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose. GDP-L-fucose is the substrate of several fucosyltransferases involved in the expression of many glycoconjugates, including blood group ABH antigens and developmental adhesion antigens. Mutations in this gene may cause leukocyte adhesion deficiency, type II. [provided by RefSeq, Jul 2008]

GFUS Products(9)

mRNA	Protein	Name
NM_001317783.2	NP_001304712.1	GDP-L-fucose synthase isoform 1
NM_001413407.1	NP_001400336.1	GDP-L-fucose synthase isoform 3
NM_001413408.1	NP_001400337.1	GDP-L-fucose synthase isoform 2
NM_001413409.1	NP_001400338.1	GDP-L-fucose synthase isoform 4
NM_001413410.1	NP_001400339.1	GDP-L-fucose synthase isoform 5
NM_001413411.1	NP_001400340.1	GDP-L-fucose synthase isoform 6
NM_001413412.1	NP_001400341.1	GDP-L-fucose synthase isoform 7
NM_001413413.1	NP_001400342.1	GDP-L-fucose synthase isoform 8
NM_003313.4	NP_003304.1	GDP-L-fucose synthase isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GDP-L-fucose synthase activity	IDA IDA: Inferred from direct assay	8910301	GOA
enables GDP-mannose 3,5-epimerase activity	IDA IDA: Inferred from direct assay	8910301	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	23774504	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in 'de novo' GDP-L-fucose biosynthetic process	IDA IDA: Inferred from direct assay	9525924	GOA
involved in GDP-mannose metabolic process	IDA IDA: Inferred from direct assay	9525924	GOA
involved in positive regulation of endothelial cell migration	IMP IMP: Inferred from mutant phenotype	18205178	GOA
involved in positive regulation of endothelial cell-matrix adhesion via fibronectin	IMP IMP: Inferred from mutant phenotype	18205178	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	8910301	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GFUS Protein Structure

Epimerase

0
100
200
300
321 a.a.

Protein Preferred Names

Protein Names

GDP-L-fucose synthase

3-5 epimerase/4-reductase

GFUS Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GFUS	Q13630	CLVS2	Homo sapiens	Q5SYC1	Validated Y2H	32296183
Intra	GFUS	Q13630	CLVS2	Homo sapiens	Q5SYC1	Y2H Array	32296183
Intra	GFUS	Q13630	CLVS2	Homo sapiens	Q5SYC1	Y2H Prey Pooling	32296183
Intra	GFUS	Q13630	ID2	Homo sapiens	Q02363	Y2H Array	21988832
Intra	GFUS	Q13630	GFUS	Homo sapiens	Q13630	Validated Y2H	32296183
Intra	GFUS	Q13630	PCBP3	Homo sapiens	P57721	Anti Tag CoIP	33961781
Intra	GFUS	Q13630	GFUS	Homo sapiens	Q13630	Y2H Prey Pooling	32296183
Intra	GFUS	Q13630	KLHL15	Homo sapiens	Q96M94	Anti Tag CoIP	33961781
Intra	GFUS	Q13630	PCBP3	Homo sapiens	P57721-2	Anti Tag CoIP	28514442
Intra	GFUS	Q13630	GFUS	Homo sapiens	Q13630	X-Ray Diffraction	23774504
Intra	GFUS	Q13630	GFUS	Homo sapiens	Q13630	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GFUS Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71390	TSTA3 Protein, Human (His)	Q13630 (M1-K321)	≥95%

Related Diseases

Diseases

Alias

Retinitis Pigmentosa 40

RP40	Retinitis Pigmentosa-40
Retinitis Pigmentosa, Type 40

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05391	GFUS Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GFUS	VGNC	VGNC:47933
Bos taurus	GFUS	VGNC	VGNC:36450
Macaca mulatta	GFUS	VGNC	VGNC:78666
Rattus norvegicus	GFUS	RGD	RGD:1307028
Mus musculus	GFUS	MGD	MGI:98857
Felis catus	GFUS	VGNC	VGNC:66648

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