2. Gene
  3. TTC3 - tetratricopeptide repeat domain 3 Gene

TTC3 - tetratricopeptide repeat domain 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DCRR1; RNF105; TPRDIII

Gene ID: 7267 | Gene type: protein coding

About TTC3

Cytogenetic location: 21q22.13 Genomic coordinates (GRCh38): 21:37,073,254-37,203,118 (from NCBI)

This gene has 26 transcripts (splice variants) and 233 orthologues. Ubiquitous expression in brain (RPKM 28.4), thyroid (RPKM 22.3) and 25 other tissues.

Summary

Enables ubiquitin-protein transferase activity. Involved in protein K48-linked ubiquitination and ubiquitin-dependent protein catabolic process. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TTC3 Products(10)

mRNA Protein Name
NM_001001894.3 NP_001001894.1 E3 ubiquitin-protein ligase TTC3 isoform 1
NM_001320703.2 NP_001307632.1 E3 ubiquitin-protein ligase TTC3 isoform 3
NM_001320704.2 NP_001307633.1 E3 ubiquitin-protein ligase TTC3 isoform 2
NM_001330681.2 NP_001317610.1 E3 ubiquitin-protein ligase TTC3 isoform 4
NM_001330682.2 NP_001317611.1 E3 ubiquitin-protein ligase TTC3 isoform 4
NM_001330683.2 NP_001317612.1 E3 ubiquitin-protein ligase TTC3 isoform 1
NM_001353936.2 NP_001340865.1 E3 ubiquitin-protein ligase TTC3 isoform 4
NM_001353937.2 NP_001340866.1 E3 ubiquitin-protein ligase TTC3 isoform 5
NM_001353938.2 NP_001340867.1 E3 ubiquitin-protein ligase TTC3 isoform 5
NM_003316.4 NP_003307.3 E3 ubiquitin-protein ligase TTC3 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
20059950 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
20059950 GOA
Biological Process GO Annotation Evidence Reference Source
involved in protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
20059950 GOA
involved in ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
20059950 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
20059950 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TTC3 Protein Structure

TPR_11

TPR_11: TPR repeat (233 - 291)

TPR_1

TPR_1: Tetratricopeptide repeat (578 - 603)

zf-RING_2

zf-RING_2: Ring finger domain (1956 - 1996)

  • 0
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  • 1600
  • 2025 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase TTC3

RING finger protein 105

Related Diseases

Diseases Alias
Down Syndrome

Trisomy 21

Complete Trisomy 21 Syndrome

Down'S Syndrome

Trisomy 21 Syndrome

Down'S Syndrome - Trisomy 21

Downs Syndrome

G Trisomy

47,Xx,+21

47,Xy,+21

Trisomy G

Down Syndrome, Susceptibility To

Chromosome 21 Trisomy

Trisomy 21 Nos

Abnormal Autosomes 21
Intellectual Developmental Disorder, Autosomal Dominant 7

MRD7

Mental Retardation, Autosomal Dominant 7

Autosomal Dominant Non-Syndromic Intellectual Disability 7

Dyrk1a Syndrome

Autosomal Dominant Intellectual Developmental Disorder 7

Autosomal Dominant Mental Retardation 7

Mental Retardation, Autosomal Dominant, Type 7
Cataract 4, Multiple Types

Cataract 4 Multiple Types

CTRCT4

Cca3

Pcc

Aculeiform Cataract

Cataract 4, Multiple Types, With Or Without Microcornea

Cataract, Crystalline Aculeiform

Caca

Cataract, Congenital, Cerulean Type, 3

Congenital Cataract Cerulean Type 3

Cataract Congenital Dominant Non Nuclear

Ccp

Cataract, Nonnuclear Polymorphic Congenital

Cataract, Punctate, Progressive Juvenile-Onset

Cataract 4 Multiple Types With Or Without Microcornea

Autosomal Dominant Nonnuclear Polymorphic Congenital Cataract

Cataract, Polymorphic Congenital

Congenital Cataract Blue Dot Type 3

Congenital Non-Nuclear Polymorphic Cataract

Crystalline Aculeiform Cataract

Punctate, Progressive Juvenile-Onset, Cataract

Cataract, Nonnuclear Polymorphic Congenital, Autosomal Dominant
Chromosomal Duplication Syndrome
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15208 TTC3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TTC3 VGNC VGNC:36469
Canis familiaris TTC3 VGNC VGNC:47950
Mus musculus TTC3 MGD MGI:1276539
Rattus norvegicus TTC3 RGD RGD:1308654
Macaca mulatta TTC3 VGNC VGNC:81785