2. Gene
  3. SMURF2 - SMAD specific E3 ubiquitin protein ligase 2 Gene

SMURF2 - SMAD specific E3 ubiquitin protein ligase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 64750 | Gene type: protein coding

About SMURF2

Cytogenetic location: 17q23.3-q24.1 Genomic coordinates (GRCh38): 17:64,542,282-64,662,307 (from NCBI)

This gene has 7 transcripts (splice variants), 281 orthologues and 24 paralogues. Ubiquitous expression in lung (RPKM 7.9), testis (RPKM 7.6) and 25 other tissues.

Summary

Enables SMAD binding activity; identical protein binding activity; and ubiquitin-protein transferase activity. Involved in negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of trophoblast cell migration; and ubiquitin-dependent SMAD protein catabolic process. Located in nuclear speck. Part of ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

SMURF2 Products(1)

mRNA Protein Name
NM_022739.4 NP_073576.1 E3 ubiquitin-protein ligase SMURF2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables SMAD binding IPI
IPI: Inferred from physical interaction
19122240 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
15231748 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
14755250 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
19122240 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
14755250 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
19255252 GOA
involved in negative regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
21791611 GOA
involved in positive regulation of trophoblast cell migration IDA
IDA: Inferred from direct assay
19255252 GOA
involved in ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
14755250 GOA
Cellular Component GO Annotation Evidence Reference Source
part of ubiquitin ligase complex IDA
IDA: Inferred from direct assay
14755250 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SMURF2 Protein Structure

C2

C2: C2 domain (14 - 96)

WW

WW: WW domain (159 - 188)

WW

WW: WW domain (253 - 282)

WW

WW: WW domain (299 - 328)

HECT

HECT: HECT-domain (ubiquitin-transferase) (443 - 747)

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  • 748 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase SMURF2

E3 ubiquitin ligase SMURF2

SMURF2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra SMURF2 Q9HAU4 SMAD2 Homo sapiens Q15796
Y2H
15231748
Intra SMURF2 Q9HAU4 SMAD2 Homo sapiens Q15796
NMR
20937913
Intra SMURF2 Q9HAU4 SMAD1 Homo sapiens Q15797
Anti Tag CoIP
28514442
Intra SMURF2 Q9HAU4 SMAD1 Homo sapiens Q15797
NMR
20937913
Intra SMURF2 Q9HAU4 SMAD1 Homo sapiens Q15797
Anti Tag CoIP
33961781
Intra SMURF2 Q9HAU4 NEDD4 Homo sapiens P46934-4
Anti Tag CoIP
28514442
Intra SMURF2 Q9HAU4 SMAD3 Homo sapiens P84022
Anti Tag CoIP
22045334
Intra SMURF2 Q9HAU4 SMAD3 Homo sapiens P84022
Peptide Array
22045334
Intra SMURF2 Q9HAU4 SMAD7 Homo sapiens O15105
NMR
20937913
Intra SMURF2 Q9HAU4 SMAD7 Homo sapiens O15105
Fluorescence Spectr
20937913
Intra SMURF2 Q9HAU4 RNF11 Homo sapiens Q9Y3C5
Y2H
15231748
Intra SMURF2 Q9HAU4 RNF11 Homo sapiens Q9Y3C5
Anti Tag CoIP
14755250
Intra SMURF2 Q9HAU4 UBB Homo sapiens P0CG47
Enzymatic Study
17719543
Intra SMURF2 Q9HAU4 FBXL15 Homo sapiens Q9H469
Pull Down
21572392
Intra SMURF2 Q9HAU4 SMAD5 Homo sapiens Q99717
Anti Tag CoIP
33961781
Intra SMURF2 Q9HAU4 SMAD5 Homo sapiens Q99717
Anti Tag CoIP
28514442
Intra SMURF2 Q9HAU4 DAZAP2 Homo sapiens Q15038
Y2H
15231748
Cross SMURF2 Q9HAU4 Q9WMX2-PRO_0000037548 Hepatitis C virus Q9WMX2-PRO_0000037548
Pull Down
18985028
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-110204 Heclin Inhibitor 98.21% Unkown
HY-RS13460 SMURF2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SMURF2 RGD RGD:1310067
Mus musculus SMURF2 MGD MGI:1913563
Felis catus SMURF2 VGNC VGNC:65511
Bos taurus SMURF2 VGNC VGNC:35041
Macaca mulatta SMURF2 VGNC VGNC:77727
Others SMURF2 NCBI