Adipor1 - adiponectin receptor 1 Gene

Mus musculus

Also known as Paqr1; ACDCR1; CGI-45; 2810031L11Rik

Gene ID: 72674 | Gene type: protein coding

About Adipor1

Summary

This gene encodes a receptor for the fat-derived hormone Adiponectin. Binding of Adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and Insulin sensitivity. Homozygous knockout mice for this gene exhibit elevated plasma glucose and Insulin levels as well as impaired glucose tolerance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Adipor1 Products(2)

mRNA	Protein	Name
NM_001306069.1	NP_001292998.1	adiponectin receptor protein 1
NM_028320.4	NP_082596.2	adiponectin receptor protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables adiponectin binding	IPI IPI: Inferred from physical interaction	12802337	MGI
enables identical protein binding	IDA IDA: Inferred from direct assay	12802337	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12802337	MGI
enables signaling receptor activity	IDA IDA: Inferred from direct assay	12802337	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within adiponectin-activated signaling pathway	IDA IDA: Inferred from direct assay	12802337	MGI
involved in adiponectin-activated signaling pathway	IMP IMP: Inferred from mutant phenotype	24742672	MGI
involved in glucose homeostasis	IMP IMP: Inferred from mutant phenotype	24742672	MGI
involved in positive regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	24531262	MGI
involved in regulation of glucose metabolic process	IMP IMP: Inferred from mutant phenotype	24742672	MGI
involved in regulation of lipid metabolic process	IMP IMP: Inferred from mutant phenotype	24742672	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	12802337	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

adiponectin receptor protein 1

progestin and adipoQ receptor family member 1

progestin and adipoQ receptor family member I

Adipor1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Adipor1	Q91VH1	APPL1	Homo sapiens	Q9UKG1	Y2H	16622416
Cross	Adipor1	Q91VH1	APPL1	Homo sapiens	Q9UKG1	Pull Down	16622416

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15848	AdipoRon	Agonist	99.88%	Unkown
HY-N0166	Gramine		99.80%	Unkown
HY-N9182	Zeaxanthin dipalmitate	Inducer	≥98.0%	Unkown
HY-110164	AdipoRon hydrochloride	Agonist	/	Unkown
HY-N0166R	Gramine (Standard)		/	Unkown
HY-RS00379	ADIPOR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adipor1	NCBI	NCBI:51094

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